Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.
1. Introduction - p. 2 2. Key Concepts of Biological Nanosynthesis, State of the Art - p. 4 3. Biosynthesis of NPs by Bacteria - p. 6 4. Biosynthesis of NPs by Fungi - p. 15 5. Biosynthesis of NPs in Plant Extracts - p. 23 6. Core@Shell and Mixed NPs - p. 41 7. Mechanistic Concepts - p. 53 8. Summary - p. 60 9. Terms, Abbreviations, and Acronyms - p. 61 10. Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions - p. 69 11. Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms - p. 115 12. Chapter 4. Phyllobilins: A New Group of Bioactive Compounds - p. 159 13. Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient - p. 193 14. Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease - p. 231 15. Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems - p. 269 16. Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets - p. 303 17. Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments - p. 337 18. Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies - p. 373 19. Introduction - p. 374 20. Anticancer Activities of Apocynaceaeous Alkaloids - p. 377 21. Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids - p. 440 22. Biocidal Activities of Apocynaceaeous Alkaloids - p. 445 23. Other Pharmacological Properties of Apocynaceaeous Alkaloids - p. 458 24. Structure Activity Relationships - p. 470 25. Derivatives and Synthetic Analogues - p. 474 26. Concluding Remarks - p. 475 27. Abbreviations - p. 476 28. Index - p. 489
Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.
1. Introduction - p. 2 2. Key Concepts of Biological Nanosynthesis, State of the Art - p. 4 3. Biosynthesis of NPs by Bacteria - p. 6 4. Biosynthesis of NPs by Fungi - p. 15 5. Biosynthesis of NPs in Plant Extracts - p. 23 6. Core@Shell and Mixed NPs - p. 41 7. Mechanistic Concepts - p. 53 8. Summary - p. 60 9. Terms, Abbreviations, and Acronyms - p. 61 10. Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions - p. 69 11. Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms - p. 115 12. Chapter 4. Phyllobilins: A New Group of Bioactive Compounds - p. 159 13. Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient - p. 193 14. Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease - p. 231 15. Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems - p. 269 16. Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets - p. 303 17. Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments - p. 337 18. Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies - p. 373 19. Introduction - p. 374 20. Anticancer Activities of Apocynaceaeous Alkaloids - p. 377 21. Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids - p. 440 22. Biocidal Activities of Apocynaceaeous Alkaloids - p. 445 23. Other Pharmacological Properties of Apocynaceaeous Alkaloids - p. 458 24. Structure Activity Relationships - p. 470 25. Derivatives and Synthetic Analogues - p. 474 26. Concluding Remarks - p. 475 27. Abbreviations - p. 476 28. Index - p. 489
