Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders.
1. Chapter 1. Introduction - p. 1 2. Part I: Synaptic Biophysics and Nerve Terminal Structure - p. 4 3. Chapter 2. The Formation and Structure of Synapses - p. 7 4. Chapter 3. Basics of Cellular Neurophysiology - p. 19 5. Chapter 4. Ion Channels and Action Potential Generation - p. 35 6. Chapter 5. Electrical Synapses - p. 65 7. Part II: Regulation of Chemical Transmitter Release - p. 89 8. Chapter 6. Function of Chemical Synapses and the Quantal Theory of Transmitter Release - p. 95 9. Chapter 7. Calcium Homeostasis, Calcium Channels, and Transmitter Release - p. 121 10. Chapter 8. Cellular and Molecular Mechanisms of Exocytosis - p. 155 11. Chapter 9. Cellular and Molecular Mechanisms of Endocytosis and Synaptic Vesicle Trafficking - p. 189 12. Part III: Receptors and Signaling - p. 203 13. Chapter 10. Introduction to Receptors - p. 209 14. Chapter 11. Ionotropic Receptors - p. 215 15. Chapter 12. Metabotropic G-Protein-Coupled Receptors and Their Cytoplasmic Signaling Pathways - p. 245 16. Chapter 13. Synaptic Integration Within Postsynaptic Neurons - p. 275 17. Chapter 14. Synaptic Plasticity - p. 287 18. Part IV: Chemical Transmitters - p. 323 19. Chapter 15. Introduction to Chemical Transmitter Systems - p. 333 20. Chapter 16. Acetylcholine - p. 345 21. Chapter 17. Monoamine Transmitters - p. 369 22. Chapter 18. Amino Acid Neurotransmitters - p. 399 23. Chapter 19. Neuropeptide Transmitters - p. 421 24. Chapter 20. Gaseous Neurotransmitters - p. 435 25. Chapter 21. The Use of Multiple Neurotransmitters at Synapses - p. 449 26. Chapter 22. Complex Signaling Within Tripartite Synapses - p. 481 27. Glossary - p. 493 28. Index - p. 499
Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders.
1. Chapter 1. Introduction - p. 1 2. Part I: Synaptic Biophysics and Nerve Terminal Structure - p. 4 3. Chapter 2. The Formation and Structure of Synapses - p. 7 4. Chapter 3. Basics of Cellular Neurophysiology - p. 19 5. Chapter 4. Ion Channels and Action Potential Generation - p. 35 6. Chapter 5. Electrical Synapses - p. 65 7. Part II: Regulation of Chemical Transmitter Release - p. 89 8. Chapter 6. Function of Chemical Synapses and the Quantal Theory of Transmitter Release - p. 95 9. Chapter 7. Calcium Homeostasis, Calcium Channels, and Transmitter Release - p. 121 10. Chapter 8. Cellular and Molecular Mechanisms of Exocytosis - p. 155 11. Chapter 9. Cellular and Molecular Mechanisms of Endocytosis and Synaptic Vesicle Trafficking - p. 189 12. Part III: Receptors and Signaling - p. 203 13. Chapter 10. Introduction to Receptors - p. 209 14. Chapter 11. Ionotropic Receptors - p. 215 15. Chapter 12. Metabotropic G-Protein-Coupled Receptors and Their Cytoplasmic Signaling Pathways - p. 245 16. Chapter 13. Synaptic Integration Within Postsynaptic Neurons - p. 275 17. Chapter 14. Synaptic Plasticity - p. 287 18. Part IV: Chemical Transmitters - p. 323 19. Chapter 15. Introduction to Chemical Transmitter Systems - p. 333 20. Chapter 16. Acetylcholine - p. 345 21. Chapter 17. Monoamine Transmitters - p. 369 22. Chapter 18. Amino Acid Neurotransmitters - p. 399 23. Chapter 19. Neuropeptide Transmitters - p. 421 24. Chapter 20. Gaseous Neurotransmitters - p. 435 25. Chapter 21. The Use of Multiple Neurotransmitters at Synapses - p. 449 26. Chapter 22. Complex Signaling Within Tripartite Synapses - p. 481 27. Glossary - p. 493 28. Index - p. 499
