This issue brings the rheumatologist on the current thinking on treatment of Systemic Lupus Erythematosus, with an eye to the future. Topics covered include B cell biology and related therapies; glutamate receptor biology and its clinical significance in neuropsychiatric SLE; platelet C4d and vascular complications; biomarkers in lupus nephritis; endothelial function and its implications for cardiovascular and renal disease in SLE; changing worldwide epidemiology of SLE and its relationship to environmental, ethnic, and other sociodemographic factors; work loss, disability, quality of life, and compliance in SLE; pediatric lupus; metabolic syndrome and related endocrine abnormalities; the significance of interferon and the consequences of anti-interferon in SLE; and cutaneous lupus and the CLASI instrument.
1. Cover - p. 1 2. Contributors - p. 2 3. Contents - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Changing Worldwide Epidemiology of Systemic Lupus Erythematosus - p. 6 7. Health-Related Quality of Life and Employment Among Persons with Systemic Lupus Erythematosus - p. 12 8. Cutaneous Lupus and the Cutaneous Lupus Erythematosus Disease Area and Severity Index Instrument - p. 20 9. Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus? - p. 30 10. The Metabolic Syndrome in Systemic Lupus Erythematosus - p. 43 11. Gonadal Failure with Cyclophosphamide Therapy for Lupus Nephritis: Advances in Fertility Preservation - p. 52 12. B-cell Biology and Related Therapies in Systemic Lupus Erythematosus - p. 59 13. Biomarkers in Lupus Nephritis - p. 71 14. Endothelial Function and its Implications for Cardiovascular and Renal Disease in Systemic Lupus Erythematosus - p. 78 15. Cell-Bound Complement Biomarkers for Systemic Lupus Erythematosus: From Benchtop to Bedside - p. 88 16. Interferon-alpha: A Therapeutic Target in Systemic Lupus Erythematosus - p. 94 17. Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus - p. 101 18. Index - p. 110
This issue brings the rheumatologist on the current thinking on treatment of Systemic Lupus Erythematosus, with an eye to the future. Topics covered include B cell biology and related therapies; glutamate receptor biology and its clinical significance in neuropsychiatric SLE; platelet C4d and vascular complications; biomarkers in lupus nephritis; endothelial function and its implications for cardiovascular and renal disease in SLE; changing worldwide epidemiology of SLE and its relationship to environmental, ethnic, and other sociodemographic factors; work loss, disability, quality of life, and compliance in SLE; pediatric lupus; metabolic syndrome and related endocrine abnormalities; the significance of interferon and the consequences of anti-interferon in SLE; and cutaneous lupus and the CLASI instrument.
1. Cover - p. 1 2. Contributors - p. 2 3. Contents - p. 3 4. Forthcoming Issues - p. 4 5. Preface - p. 5 6. Changing Worldwide Epidemiology of Systemic Lupus Erythematosus - p. 6 7. Health-Related Quality of Life and Employment Among Persons with Systemic Lupus Erythematosus - p. 12 8. Cutaneous Lupus and the Cutaneous Lupus Erythematosus Disease Area and Severity Index Instrument - p. 20 9. Pediatric Lupus—Are There Differences in Presentation, Genetics, Response to Therapy, and Damage Accrual Compared with Adult Lupus? - p. 30 10. The Metabolic Syndrome in Systemic Lupus Erythematosus - p. 43 11. Gonadal Failure with Cyclophosphamide Therapy for Lupus Nephritis: Advances in Fertility Preservation - p. 52 12. B-cell Biology and Related Therapies in Systemic Lupus Erythematosus - p. 59 13. Biomarkers in Lupus Nephritis - p. 71 14. Endothelial Function and its Implications for Cardiovascular and Renal Disease in Systemic Lupus Erythematosus - p. 78 15. Cell-Bound Complement Biomarkers for Systemic Lupus Erythematosus: From Benchtop to Bedside - p. 88 16. Interferon-alpha: A Therapeutic Target in Systemic Lupus Erythematosus - p. 94 17. Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus - p. 101 18. Index - p. 110
