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Textbook of Pediatric Rheumatology

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Descripción

This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic conditions. Global leaders in the field provide evidence-based guidance highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies the investigation, recognition, and management of rheumatic diseases in childhood and adolescence.

  • Addresses the full spectrum of rheumatic diseases, from typical juvenile idiopathic arthritis to rare and newly recognized syndromes, providing practical guidance on diagnosis, outcome measurement, and management—including both pharmacologic and multidisciplinary strategies
  • Covers state-of-the-art advances in pediatric rheumatology, including genomic and multi-omics approaches, the latest targeted therapies, modern imaging, and evolving concepts in autoinflammation and immune deficiency
  • Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible, and provides updates of laboratory investigations, imaging techniques, physical and occupational therapy, approach to chronic musculoskeletal pain syndromes, and much more
  • Features reviews of the complex symptoms, signs, and laboratory abnormalities that characterize these disorders
  • Shares the knowledge and expertise of two new editors, Drs. Jonathan Akikusa and Hermine Brunner, and 38 new contributing authors who are international leaders in the field of pediatric rheumatology
  • Any additional digital ancillary content may publish up to 6 weeks following the publication date

1. SECTION A Introduction - p. p1 2. 1 Evolution of Pediatric Rheumatology - p. 1 3. Section B Basic Concepts - p. p9 4. 2 Structure and Function - p. 9 5. 3 Innate Immunity - p. 18 6. 4 Adaptive Immunity - p. 36 7. 5 Multiomics Approaches to Rheumatic Disease - p. 49 8. 6 Genetics and Pediatric Rheumatic Diseases - p. 57 9. Section C Clinical Research in Pediatric Rheumatology - p. p71 10. 7 Understanding Clinical Investigations - p. 71 11. 8 Clinical Outcome Measures in Pediatric Rheumatic Diseases - p. 89 12. Section D Clinical Investigations in Pediatric Rheumatology - p. p105 13. 9 Laboratory Investigations - p. 105 14. 10 Imaging in Pediatric Rheumatic Diseases - p. 122 15. Section E Management of Rheumatic Diseases in Children - p. p145 16. 11 Principles in the Management of Patients With Rheumatic Diseases - p. 145 17. 12 Therapeutics: Nonbiologics - p. 153 18. 13 Therapeutics: Biologics and Targeted Small Molecules - p. 169 19. 14 Physical and Occupational Therapy - p. 193 20. 15 The Assessment and Management of Osteoporosis in Childhood - p. 211 21. Section F Juvenile Idiopathic Arthritis and Related Conditions - p. p227 22. 16 Juvenile Idiopathic Arthritis: Classification and Basic Concepts - p. 227 23. 17 Systemic Juvenile Idiopathic Arthritis - p. 235 24. 18 Polyarticular Juvenile Idiopathic Arthritis - p. 247 25. 19 Oligoarticular Juvenile Idiopathic Arthritis - p. 260 26. 20 Enthesitis-Related Juvenile Idiopathic Arthritis - p. 271 27. 21 Psoriatic Juvenile Idiopathic Arthritis - p. 286 28. 22 Uveitis in Juvenile Idiopathic Arthritis - p. 298 29. Section G Arthritis Related to Infection - p. p313 30. 23 Acute Rheumatic Fever and Post-streptococcal Arthritis - p. 313 31. 24 Reactive Arthritis - p. 325 32. 25 Lyme Disease - p. 332 33. 26 Infectious Arthritis and Osteomyelitis - p. 344 34. Section H Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes - p. p359 35. 27 Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease - p. 359 36. 28 Neonatal Lupus Erythematosus - p. 395 37. 29 Antiphospholipid Syndrome - p. 407 38. 30 Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases - p. 424 39. 31 Juvenile Systemic Sclerosis - p. 443 40. 32 Localized Scleroderma and Eosinophilic Fasciitis - p. 471 41. 33 Sjögren Disease and Immunoglobulin-G4–Related Disease - p. 489 42. 34 Raynaud Phenomena and Vasomotor Syndromes - p. 500 43. 35 Inflammatory Central Nervous System Disorders - p. 513 44. Section I Vasculitis - p. p525 45. 36 Vasculitis and Its Classification - p. 525 46. 37 Takayasu Arteritis - p. 530 47. 38 Polyarteritis Nodosa - p. 539 48. 39 Kawasaki Disease - p. 546 49. 40 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 558 50. 41 Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis - p. 574 51. 42 Behcet Syndrome and Its Mimics - p. 583 52. 43 Central Nervous System Vasculitis - p. 594 53. 44 Other Vasculitides - p. 601 54. Section J Immune System Dysfunction, Autoinflammation, and Immune Deficiency - p. p617 55. 45 Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases - p. 617 56. 46 Autoinflammatory Bone Diseases - p. 643 57. 47 Blau Syndrome, Sarcoidosis, and Related Systemic Granulomatous Diseases - p. 660 58. 48 Macrophage Activation Syndrome - p. 669 59. 49 Inborn Errors of Immunity and Rheumatic Disease - p. 678 60. Section K Musculoskeletal Manifestations of Systemic Disorders - p. p691 61. 50 Malignancies and Nonmalignant Musculoskeletal Conditions That May Mimic Rheumatic Disease - p. 691 62. 51 Musculoskeletal Manifestations of Inflammatory Bowel Disease - p. 709 63. 52 Musculoskeletal Manifestations of Systemic Disease - p. 716 64. Section L Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes - p. p727 65. 53 Primary Disorders of Connective Tissue - p. 727 66. 54 Localized Musculoskeletal Pain - p. 741 67. 55 Primary and Secondary Chronic Musculoskeletal Pain Syndromes - p. 763 68. Index - p. 775

Descripcion
Descripción

This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic conditions. Global leaders in the field provide evidence-based guidance highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies the investigation, recognition, and management of rheumatic diseases in childhood and adolescence.

  • Addresses the full spectrum of rheumatic diseases, from typical juvenile idiopathic arthritis to rare and newly recognized syndromes, providing practical guidance on diagnosis, outcome measurement, and management—including both pharmacologic and multidisciplinary strategies
  • Covers state-of-the-art advances in pediatric rheumatology, including genomic and multi-omics approaches, the latest targeted therapies, modern imaging, and evolving concepts in autoinflammation and immune deficiency
  • Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible, and provides updates of laboratory investigations, imaging techniques, physical and occupational therapy, approach to chronic musculoskeletal pain syndromes, and much more
  • Features reviews of the complex symptoms, signs, and laboratory abnormalities that characterize these disorders
  • Shares the knowledge and expertise of two new editors, Drs. Jonathan Akikusa and Hermine Brunner, and 38 new contributing authors who are international leaders in the field of pediatric rheumatology
  • Any additional digital ancillary content may publish up to 6 weeks following the publication date

1. SECTION A Introduction - p. p1 2. 1 Evolution of Pediatric Rheumatology - p. 1 3. Section B Basic Concepts - p. p9 4. 2 Structure and Function - p. 9 5. 3 Innate Immunity - p. 18 6. 4 Adaptive Immunity - p. 36 7. 5 Multiomics Approaches to Rheumatic Disease - p. 49 8. 6 Genetics and Pediatric Rheumatic Diseases - p. 57 9. Section C Clinical Research in Pediatric Rheumatology - p. p71 10. 7 Understanding Clinical Investigations - p. 71 11. 8 Clinical Outcome Measures in Pediatric Rheumatic Diseases - p. 89 12. Section D Clinical Investigations in Pediatric Rheumatology - p. p105 13. 9 Laboratory Investigations - p. 105 14. 10 Imaging in Pediatric Rheumatic Diseases - p. 122 15. Section E Management of Rheumatic Diseases in Children - p. p145 16. 11 Principles in the Management of Patients With Rheumatic Diseases - p. 145 17. 12 Therapeutics: Nonbiologics - p. 153 18. 13 Therapeutics: Biologics and Targeted Small Molecules - p. 169 19. 14 Physical and Occupational Therapy - p. 193 20. 15 The Assessment and Management of Osteoporosis in Childhood - p. 211 21. Section F Juvenile Idiopathic Arthritis and Related Conditions - p. p227 22. 16 Juvenile Idiopathic Arthritis: Classification and Basic Concepts - p. 227 23. 17 Systemic Juvenile Idiopathic Arthritis - p. 235 24. 18 Polyarticular Juvenile Idiopathic Arthritis - p. 247 25. 19 Oligoarticular Juvenile Idiopathic Arthritis - p. 260 26. 20 Enthesitis-Related Juvenile Idiopathic Arthritis - p. 271 27. 21 Psoriatic Juvenile Idiopathic Arthritis - p. 286 28. 22 Uveitis in Juvenile Idiopathic Arthritis - p. 298 29. Section G Arthritis Related to Infection - p. p313 30. 23 Acute Rheumatic Fever and Post-streptococcal Arthritis - p. 313 31. 24 Reactive Arthritis - p. 325 32. 25 Lyme Disease - p. 332 33. 26 Infectious Arthritis and Osteomyelitis - p. 344 34. Section H Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes - p. p359 35. 27 Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease - p. 359 36. 28 Neonatal Lupus Erythematosus - p. 395 37. 29 Antiphospholipid Syndrome - p. 407 38. 30 Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases - p. 424 39. 31 Juvenile Systemic Sclerosis - p. 443 40. 32 Localized Scleroderma and Eosinophilic Fasciitis - p. 471 41. 33 Sjögren Disease and Immunoglobulin-G4–Related Disease - p. 489 42. 34 Raynaud Phenomena and Vasomotor Syndromes - p. 500 43. 35 Inflammatory Central Nervous System Disorders - p. 513 44. Section I Vasculitis - p. p525 45. 36 Vasculitis and Its Classification - p. 525 46. 37 Takayasu Arteritis - p. 530 47. 38 Polyarteritis Nodosa - p. 539 48. 39 Kawasaki Disease - p. 546 49. 40 Antineutrophil Cytoplasmic Antibody-Associated Vasculitis - p. 558 50. 41 Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis - p. 574 51. 42 Behcet Syndrome and Its Mimics - p. 583 52. 43 Central Nervous System Vasculitis - p. 594 53. 44 Other Vasculitides - p. 601 54. Section J Immune System Dysfunction, Autoinflammation, and Immune Deficiency - p. p617 55. 45 Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases - p. 617 56. 46 Autoinflammatory Bone Diseases - p. 643 57. 47 Blau Syndrome, Sarcoidosis, and Related Systemic Granulomatous Diseases - p. 660 58. 48 Macrophage Activation Syndrome - p. 669 59. 49 Inborn Errors of Immunity and Rheumatic Disease - p. 678 60. Section K Musculoskeletal Manifestations of Systemic Disorders - p. p691 61. 50 Malignancies and Nonmalignant Musculoskeletal Conditions That May Mimic Rheumatic Disease - p. 691 62. 51 Musculoskeletal Manifestations of Inflammatory Bowel Disease - p. 709 63. 52 Musculoskeletal Manifestations of Systemic Disease - p. 716 64. Section L Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes - p. p727 65. 53 Primary Disorders of Connective Tissue - p. 727 66. 54 Localized Musculoskeletal Pain - p. 741 67. 55 Primary and Secondary Chronic Musculoskeletal Pain Syndromes - p. 763 68. Index - p. 775

Indice
Autores
Muestra
Ficha Técnica