The Breast

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedicated - p. vi 6. Contributors - p. vii 7. Preface - p. xv 8. Acknowledgments - p. xvii 9. Videos - p. xviii 10. Section I: History of the Therapy of Breast Cancer - p. xviii 11. 1. The History of the Therapy for Breast Cancer - p. 1 12. Non-Print Item Abstract - p. 1 13. Ancient Civilizations - p. 1 14. Cultural and Religious Influences of the 2nd to 15th Centuries - p. 8 15. Scientific Progress of the Renaissance Period (14th–16th Century) - p. 10 16. 18th Century - p. 12 17. Uniform Withdrawal of Breast Therapy (Late 18th–Early 19th Centuries) - p. 15 18. 19th Century - p. 16 19. 20th Century Progress for Breast Cancer: An Appreciation for Evolving Concepts Formetastases - p. 23 20. Origins of Adjuvant Breast Cancer Therapy - p. 26 21. 20th and 21st Century Discovery with Integration of Pathology, Genomics, Immunochemistry: Evolution of the Breastcancer Subtypes - p. 37 22. Selected References - p. 41 23. References - p. 41 24. 2. History of Surgical Clinical Trials and Cooperative Group Trials - p. 42 25. 3. Important Trials of the Last Decade - p. 50 26. Section II: Anatomy and Physiology of the Normal and Lactating Breast - p. 61 27. 4. Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites - p. 62 28. 5. Breast Physiology: Normal and Abnormal Development and Function - p. 78 29. 6. Discharges and Secretions of the Nipple - p. 97 30. Section III: Natural History, Epidemiology, Genetics, and Syndromes of the Breast - p. 118 31. 7. Epidemiology of Breast Cancer - p. 119 32. 8. Carcinogenesis of Breast Cancer - p. 128 33. 9. Risk Reduction for Developing Breast Cancer - p. 133 34. 10. Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment - p. 149 35. Section IV: Screening and Diagnosis of the Breast Patient - p. 160 36. 11. Clinical Encounter With the Patient - p. 161 37. 12. Breast Cancer Screening - p. 167 38. 13. Breast Cancer Diagnosis and Techniques for Biopsy - p. 184 39. Section V: Benign and Premalignant Lesions - p. 196 40. 14. Etiology and Management of Benign Breast Disease - p. 197 41. 15. Mastitis and Breast Abscess - p. 212 42. 16. Gynecomastia - p. 223 43. 17. High-Risk and Premalignant Lesions of the Breast - p. 233 44. Section VI: Pathology of Malignant Lesions - p. 239 45. 18. Disorders of the Skin - p. 240 46. 19. Ductal Carcinoma In Situ - p. 257 47. 20. Infiltrating Carcinomas of the Breast - p. 269 48. 21. Biomarkers - p. 281 49. 22. Fibroepithelial Tumors and Hamartomas - p. 292 50. 23. Lymphomas of the Breast - p. 306 51. 24. Mesenchymal Neoplasms of the Breast - p. 313 52. 25. Unusual and Rare Tumors of the Breast - p. 319 53. Section VII: Prognostic Factors for Breast Cancer - p. 326 54. 26. Clinical Prognosis and Staging of Breast Cancer - p. 327 55. 27. Molecular Biomarkers for Breast Cancer Prognosis - p. 336 56. 28. Examining Domestic and International Disparities in Breast Cancer Screening, Treatment, and Outcomes - p. 350 57. Section VIII: Surgical Techniques of the Breast - p. 354 58. 29. Management of Lobular Neoplasia and Ductal Carcinoma in Situ - p. 355 59. 30. General Principles of Mastectomy: From Halsted Radical Mastectomy and Modified Radical Mastectomy to Total (Simple) Mastectomy - p. 368 60. 31. Breast Conservation Therapy for Invasive Breast Cancer - p. 389 61. 32. Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy - p. 404 62. 33. Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer - p. 408 63. 34. Lymphatic Mapping and Targeted Axillary Dissection Procedure After Neoadjuvant Chemotherapy - p. 434 64. 35. Therapeutic Value of Axillary Node Dissection - p. 439 65. 36. Lymphedema Prevention and Treatment: Axillary Reverse Mapping, LYMPHA, Lymph Node Transfer, and Other Surgical Techniques - p. 452 66. 37. Wound Care and Complications of Mastectomy - p. 469 67. 38. Pain Management of the Breast Cancer Surgery Patient - p. 475 68. Section IX: Oncoplastic Breast Surgery and Reconstruction - p. 479 69. 39. Optimizing Cosmetic Outcomes for Breast Surgery - p. 480 70. 40. Upper Hemisphere Oncoplastic Surgery - p. 484 71. 41. Oncoplastic Techniques for the Lower Hemisphere of the Breast - p. 495 72. 42. Oncoplastic Breast Reconstruction: Extreme Oncoplasty and Split Reduction Techniques - p. 502 73. 43. Nipple Skin-Sparing Mastectomy - p. 509 74. 44. Breast Reconstruction - p. 515 75. Section X: Adjuvant Therapy for Stages 0, I, and II Breast Cancer - p. 529 76. 45. Radiotherapy and Regional Nodes - p. 530 77. 46. Postmastectomy Radiation Therapy - p. 539 78. 47. Breast-Conserving Therapy for Invasive Breast Cancers - p. 550 79. 48. Partial Breast Irradiation: Accelerated and Intraoperative - p. 564 80. 49. Radiation Complications and Their Management - p. 573 81. 50. Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approaches - p. 583 82. 51. Systemic Therapy of Hormone-Sensitive HER2-Negative Breast Cancer: Adjuvant and Neoadjuvant - p. 592 83. 52. Adjuvant and Neoadjuvant Systemic Therapies for Triple-Negative Breast Cancer - p. 611 84. 53. Adjuvant and Neoadjuvant HER2 Therapy - p. 620 85. Section XI: Management of Advanced Local, Regional, and Systemic Disease - p. 625 86. 54. Surgical Procedures for Advanced Local and Regional Malignancies of the Breast - p. 627 87. 55. Management of the Intact Breast Primary in the Setting of Metastatic Disease - p. 641 88. 56. Locoregional Recurrence of Breast Cancer - p. 651 89. 57. Locally Advanced and Inflammatory Breast Cancer - p. 659 90. 58. Clinical Implications of Occult Systemic Micrometastatic Breast Cancer - p. 669 91. 59. Management of Breast Cancer Solitary Metastases - p. 674 92. 60. Management of Bone Metastases in Breast Cancer - p. 681 93. 61. Chemotherapy and HER2-Directed Therapy for Metastatic Breast Cancer - p. 688 94. 62. Endocrine Therapy for Late-Stage and Metastatic Breast Cancer - p. 704 95. 63. Immunological Approaches to Breast Cancer Therapy - p. 717 96. 64. Diagnosis and Management of Pleural Metastases and Malignant Effusion in Breast Cancer - p. 728 97. 65. Management of Central Nervous System Metastases in Breast Cancer - p. 736 98. Section XII: Special Presentations of Breast Cancer - p. 753 99. 66. Bilateral Breast Cancer - p. 754 100. 67. Male Breast Cancer - p. 760 101. 68. Local Recurrence, the Augmented Breast, and the Contralateral Breast - p. 764 102. 69. Carcinoma of the Breast in Pregnancy and Lactation - p. 784 103. 70. Unknown Primary Presenting With Axillary Lymphadenopathy - p. 792 104. Section XIII: Survivorship, Follow-Up Care, and Rehabilitation of the Breast Cancer Patient - p. 795 105. 71. Creating a Breast Cancer Survivorship Plan and Clinic - p. 796 106. 72. General Considerations for Follow-Up - p. 806 107. 73. Bone-Modifying Agents in Early Breast Cancer - p. 818 108. 74. Fertility Preservation for Women With Breast Cancer - p. 822 109. 75. Quality Measures and Performance Improvement for Breast Cancer Surgery - p. 827 110. 76. Lymphedema in the Postsurgical Patient: Pathophysiology and Nonoperative Management - p. 841 111. 77. Management of Menopause in Breast Cancer Survivors - p. 855 112. 78. Rehabilitation - p. 864 113. 79. Psychosocial Consequences and Lifestyle Interventions - p. 873 114. Online Appendix - p. 881 115. Index - p. 883