The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Advances in Magnetic Resonance Technology and Applications Series - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Preface - p. iii 8. Chapter 1: Hyperpolarized tracer design, synthesis, and characterization - p. 1 9. Abstract - p. 1 10. 1.1 Background - p. 1 11. 1.2 Sensitivity of NMR experiments - p. 3 12. 1.3 Conventional NMR technologies to improve the signal intensity - p. 4 13. 1.4 Hyperpolarized NMR - p. 4 14. 1.5 Polarizing agents - p. 16 15. 1.6 Relaxation of the hyperpolarized magnetization in the liquid state NMR - p. 22 16. 1.7 Various nuclei subjected to DNP - p. 29 17. 1.8 A general overview of the applications of hyperpolarized probes - p. 40 18. 1.9 Design and synthesis of 13C-labeled compounds for dissolution DNP - p. 49 19. 1.10 Conclusion and future outlook - p. 89 20. Appendix: List of T1 values - p. 91 21. References - p. 127 22. Chapter 2: Optimization of hyperpolarized NMR signals in dissolution dynamic nuclear polarization - p. 157 23. Chapter 3: The chemistry of parahydrogen induced polarization - p. 175 24. Chapter 4: Beyond 13C-pyruvate: Prospects for biomedical applications of alternative hyperpolarized probes and isotopes - p. 199 25. Chapter 5: Technical considerations of MRI methods for validating DNP probes in small animals - p. 229 26. Index - p. 248
The Chemistry of Hyperpolarized Magnetic Resonance Probes, Volume Seven focuses on the chemical aspects of hyperpolarized NMR/MRI technology, with synthesis and characterizations of labeled compounds discussed from a practical point-of-view. A brief overview of the various hyperpolarization techniques are given, with the optimization of hyperpolarization conditions and the determination of critical parameters such as polarization level and T1 relaxation values described. A practical guide on the in vivo applications of hyperpolarized compounds in small animals is also included.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Advances in Magnetic Resonance Technology and Applications Series - p. iii 5. Copyright - p. iii 6. Contributors - p. iii 7. Preface - p. iii 8. Chapter 1: Hyperpolarized tracer design, synthesis, and characterization - p. 1 9. Abstract - p. 1 10. 1.1 Background - p. 1 11. 1.2 Sensitivity of NMR experiments - p. 3 12. 1.3 Conventional NMR technologies to improve the signal intensity - p. 4 13. 1.4 Hyperpolarized NMR - p. 4 14. 1.5 Polarizing agents - p. 16 15. 1.6 Relaxation of the hyperpolarized magnetization in the liquid state NMR - p. 22 16. 1.7 Various nuclei subjected to DNP - p. 29 17. 1.8 A general overview of the applications of hyperpolarized probes - p. 40 18. 1.9 Design and synthesis of 13C-labeled compounds for dissolution DNP - p. 49 19. 1.10 Conclusion and future outlook - p. 89 20. Appendix: List of T1 values - p. 91 21. References - p. 127 22. Chapter 2: Optimization of hyperpolarized NMR signals in dissolution dynamic nuclear polarization - p. 157 23. Chapter 3: The chemistry of parahydrogen induced polarization - p. 175 24. Chapter 4: Beyond 13C-pyruvate: Prospects for biomedical applications of alternative hyperpolarized probes and isotopes - p. 199 25. Chapter 5: Technical considerations of MRI methods for validating DNP probes in small animals - p. 229 26. Index - p. 248
