Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response, Second Edition is a comprehensive and essential resource for graduate and postgraduate training of physicians, dentists, biomedical specialists, and those interested in scientific research in biology and biochemistry. The book provides an up-to-date, textbook-like description of immunology, focusing on the critical role of cytokines in immune responses. With advancements in cytokine research and signal transduction, this new and improved edition offers a deeper understanding of cytokine-receptor interactions, supported by novel figures based on crystal-structure conformations from the protein database.
These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.
1. 1. Introduction—Common features of cytokines∗ - p. 1 2. 2. The immune system—Definition and development of immunity∗ - p. 19 3. 3. Activation of cells of the immune system∗ - p. 67 4. 4. The role and regulation of the immune responses∗ - p. 109 5. 5. Cytokines with pro- and antiinflammatory activities∗ - p. 139 6. 1 IL-1 family (IL-1, IL-18, IL-33, IL-36, IL-37, IL-38) - p. 139 7. 2 IL-14 - p. 162 8. 3 IL-32 - p. 163 9. 4 TNF, LT-α (TNF-β), and LT-β - p. 167 10. 5 IL-6 family (IL-6, IL-11, IL-31, LIF, OSM) - p. 178 11. 6. Cytokines with antiviral properties—Interferons∗ - p. 227 12. 7. Adaptive immunity: T-cell helper 1 (Th1) response cytokines important for defense against intracellular bacteria and cancer∗ - p. 255 13. 8. Adaptive immunity cytokines sharing IL-2 receptor “common” gamma chain (IL-2Rγc): IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21∗ - p. 283 14. 9. “Hematopoietic lineage cell response” cytokines sharing IL-3 receptor chain, and other growth factors∗ - p. 295 15. 10. Adaptive immunity: T cell helper 2 (Th2) response cytokines crucial for humoral immunity and defense against parasites∗ - p. 311 16. 11. Adaptive immunity: T-cell helper 17 (Th17) response cytokines essential for defense against pathogenic extracellular bacteria∗ - p. 343 17. 12. Adaptive immunity: T-cell regulatory (Treg) cytokines critical for inhibiting other types of adaptive immunity and for defense against parasites∗ - p. 361 18. 13. Chemokines—Cytokines controlling cellular migrations∗ - p. 375 19. 14. Cytokine storm (septic shock and COVID-19)∗ - p. 403 20. 15. Theories about the function of the immune system∗ - p. 429 21. Index - p. 451
Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response, Second Edition is a comprehensive and essential resource for graduate and postgraduate training of physicians, dentists, biomedical specialists, and those interested in scientific research in biology and biochemistry. The book provides an up-to-date, textbook-like description of immunology, focusing on the critical role of cytokines in immune responses. With advancements in cytokine research and signal transduction, this new and improved edition offers a deeper understanding of cytokine-receptor interactions, supported by novel figures based on crystal-structure conformations from the protein database.
These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.
1. 1. Introduction—Common features of cytokines∗ - p. 1 2. 2. The immune system—Definition and development of immunity∗ - p. 19 3. 3. Activation of cells of the immune system∗ - p. 67 4. 4. The role and regulation of the immune responses∗ - p. 109 5. 5. Cytokines with pro- and antiinflammatory activities∗ - p. 139 6. 1 IL-1 family (IL-1, IL-18, IL-33, IL-36, IL-37, IL-38) - p. 139 7. 2 IL-14 - p. 162 8. 3 IL-32 - p. 163 9. 4 TNF, LT-α (TNF-β), and LT-β - p. 167 10. 5 IL-6 family (IL-6, IL-11, IL-31, LIF, OSM) - p. 178 11. 6. Cytokines with antiviral properties—Interferons∗ - p. 227 12. 7. Adaptive immunity: T-cell helper 1 (Th1) response cytokines important for defense against intracellular bacteria and cancer∗ - p. 255 13. 8. Adaptive immunity cytokines sharing IL-2 receptor “common” gamma chain (IL-2Rγc): IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21∗ - p. 283 14. 9. “Hematopoietic lineage cell response” cytokines sharing IL-3 receptor chain, and other growth factors∗ - p. 295 15. 10. Adaptive immunity: T cell helper 2 (Th2) response cytokines crucial for humoral immunity and defense against parasites∗ - p. 311 16. 11. Adaptive immunity: T-cell helper 17 (Th17) response cytokines essential for defense against pathogenic extracellular bacteria∗ - p. 343 17. 12. Adaptive immunity: T-cell regulatory (Treg) cytokines critical for inhibiting other types of adaptive immunity and for defense against parasites∗ - p. 361 18. 13. Chemokines—Cytokines controlling cellular migrations∗ - p. 375 19. 14. Cytokine storm (septic shock and COVID-19)∗ - p. 403 20. 15. Theories about the function of the immune system∗ - p. 429 21. Index - p. 451
