The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.
1. Section 1: Introduction - p. xi 2. Chapter 1: Introduction: The anterior hypothalamus - p. 3 3. Chapter 2: History of hypothalamic research: “The spring of primitive existence” - p. 36 4. Chapter 3: Anatomy and cytoarchitectonics of the human hypothalamus - p. 45 5. Chapter 4: Morphology and distribution of hypothalamic peptidergic systems - p. 67 6. Chapter 5: MRI maps, segregation, and white matter connectivity of the human hypothalamus in health - p. 87 7. Chapter 6: Magnetic resonance imaging of the hypothalamo–pituitary region - p. 95 8. Chapter 7: Resting-state functional connectivity of the human hypothalamus - p. 113 9. Chapter 8: Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology - p. 125 10. Chapter 9: Matching of the postmortem hypothalamus from patients and controls - p. 141 11. Section 2: The basal forebrain cholinergic system - p. 156 12. Chapter 10: Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration - p. 159 13. Chapter 11: The diagonal band of Broca in health and disease - p. 180 14. Chapter 12: Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease - p. 189 15. Chapter 13: Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease - p. 207 16. Chapter 14: Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease - p. 219 17. Section 3: The circadian system - p. 228 18. Chapter 15: The circadian system: From clocks to physiology - p. 233 19. Chapter 16: Development of the circadian system and relevance of periodic signals for neonatal development - p. 249 20. Chapter 17: Disrupted circadian rhythms and mental health - p. 259 21. Chapter 18: Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease - p. 271 22. Chapter 19: Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities - p. 285 23. Chapter 20: The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy - p. 301 24. Chapter 21: Retina and melanopsin neurons - p. 315 25. Chapter 22: Melatonin and the circadian system: Keys for health with a focus on sleep - p. 331 26. Chapter 23: Melatonin receptors, brain functions, and therapies - p. 345 27. Chapter 24: Chronotherapy - p. 357 28. Chapter 25: The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics - p. 371 29. Section 4: Bed nucleus of the stria terminalis and the fear circuit - p. 382 30. Chapter 26: Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function - p. 385 31. Chapter 27: Functional anatomy of the bed nucleus of the stria terminalis–hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors - p. 403 32. Chapter 28: Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions - p. 419 33. Section 5: Preoptic area - p. 432 34. Chapter 29: The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis - p. 435 35. Chapter 30: The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies - p. 455 36. Chapter 31: The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease - p. 461 37. Index - p. 469
The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus.
1. Section 1: Introduction - p. xi 2. Chapter 1: Introduction: The anterior hypothalamus - p. 3 3. Chapter 2: History of hypothalamic research: “The spring of primitive existence” - p. 36 4. Chapter 3: Anatomy and cytoarchitectonics of the human hypothalamus - p. 45 5. Chapter 4: Morphology and distribution of hypothalamic peptidergic systems - p. 67 6. Chapter 5: MRI maps, segregation, and white matter connectivity of the human hypothalamus in health - p. 87 7. Chapter 6: Magnetic resonance imaging of the hypothalamo–pituitary region - p. 95 8. Chapter 7: Resting-state functional connectivity of the human hypothalamus - p. 113 9. Chapter 8: Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology - p. 125 10. Chapter 9: Matching of the postmortem hypothalamus from patients and controls - p. 141 11. Section 2: The basal forebrain cholinergic system - p. 156 12. Chapter 10: Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration - p. 159 13. Chapter 11: The diagonal band of Broca in health and disease - p. 180 14. Chapter 12: Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease - p. 189 15. Chapter 13: Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease - p. 207 16. Chapter 14: Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease - p. 219 17. Section 3: The circadian system - p. 228 18. Chapter 15: The circadian system: From clocks to physiology - p. 233 19. Chapter 16: Development of the circadian system and relevance of periodic signals for neonatal development - p. 249 20. Chapter 17: Disrupted circadian rhythms and mental health - p. 259 21. Chapter 18: Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease - p. 271 22. Chapter 19: Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities - p. 285 23. Chapter 20: The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy - p. 301 24. Chapter 21: Retina and melanopsin neurons - p. 315 25. Chapter 22: Melatonin and the circadian system: Keys for health with a focus on sleep - p. 331 26. Chapter 23: Melatonin receptors, brain functions, and therapies - p. 345 27. Chapter 24: Chronotherapy - p. 357 28. Chapter 25: The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics - p. 371 29. Section 4: Bed nucleus of the stria terminalis and the fear circuit - p. 382 30. Chapter 26: Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function - p. 385 31. Chapter 27: Functional anatomy of the bed nucleus of the stria terminalis–hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors - p. 403 32. Chapter 28: Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions - p. 419 33. Section 5: Preoptic area - p. 432 34. Chapter 29: The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis - p. 435 35. Chapter 30: The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies - p. 455 36. Chapter 31: The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease - p. 461 37. Index - p. 469
