The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.
1. Chapter 1: Introduction: The human hypothalamus and neuropsychiatric disorders - p. 1 2. Section 21: Trauma and iatrogenic disorders - p. 5 3. Chapter 2: Chronic traumatic encephalopathy and the nucleus basalis of Meynert - p. 9 4. Section 22: Neurobehavioral disorders - p. 29 5. Chapter 3: Hypothalamic stress systems in mood disorders - p. 33 6. Chapter 4: Light therapy for mood disorders - p. 49 7. Chapter 5: Neurobiology of peripartum mental illness - p. 63 8. Chapter 6: The hypothalamo–pituitary–adrenal axis and the autonomic nervous system in burnout - p. 83 9. Chapter 7: Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation - p. 95 10. Chapter 8: The implications of hypothalamic abnormalities for schizophrenia - p. 107 11. Chapter 9: The promiscuity of the oxytocin–vasopressin systems and their involvement in autism spectrum disorder - p. 121 12. Section 23: Epilepsy - p. 140 13. Chapter 10: Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion? - p. 143 14. Chapter 11: The interactions between reproductive hormones and epilepsy - p. 155 15. Section 24: Neurodegenerative disorders - p. 174 16. Chapter 12: Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor α isoforms in the hypothalamus - p. 177 17. Chapter 13: Cholinergic neurodegeneration in Alzheimer disease mouse models - p. 201 18. Chapter 14: Autonomic disorders in Parkinson disease: Disrupted hypothalamic connectivity as revealed from resting-state functional magnetic resonance imaging - p. 211 19. Chapter 15: Hypothalamic α-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease - p. 223 20. Chapter 16: Lewy bodies in the olfactory system and the hypothalamus - p. 235 21. Chapter 17: Hypothalamic pathology in Huntington disease - p. 245 22. Chapter 18: Endocrine dysfunction in adrenoleukodystrophy - p. 257 23. Chapter 19: Hypothalamic symptoms of frontotemporal dementia disorders - p. 269 24. Section 25: Olfactory system - p. 280 25. Chapter 20: The vomeronasal organ: History, development, morphology, and functional neuroanatomy - p. 283 26. Chapter 21: Pheromone effects on the human hypothalamus in relation to sexual orientation and gender - p. 293 27. Chapter 22: Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons - p. 307 28. Chapter 23: Olfaction as an early marker of Parkinson's disease and Alzheimer's disease - p. 317 29. Section 26: Autonomic and sleep disorders - p. 329 30. Chapter 24: The hypothalamus and its role in hypertension - p. 333 31. Chapter 25: The heart is lost without the hypothalamus - p. 355 32. Chapter 26: Sleep disorders and the hypothalamus - p. 369 33. Section 27: Addiction and pain - p. 385 34. Chapter 27: Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus’ oxytocin hormone - p. 389 35. Chapter 28: The neurobiology of cluster headache - p. 401 36. Section 28: Critical care and brain-death - p. 414 37. Chapter 29: Endocrine interventions in the intensive care unit - p. 417 38. Chapter 30: Hypothalamic function in patients diagnosed as brain dead and its practical consequences - p. 433 39. Index - p. 446
The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.
1. Chapter 1: Introduction: The human hypothalamus and neuropsychiatric disorders - p. 1 2. Section 21: Trauma and iatrogenic disorders - p. 5 3. Chapter 2: Chronic traumatic encephalopathy and the nucleus basalis of Meynert - p. 9 4. Section 22: Neurobehavioral disorders - p. 29 5. Chapter 3: Hypothalamic stress systems in mood disorders - p. 33 6. Chapter 4: Light therapy for mood disorders - p. 49 7. Chapter 5: Neurobiology of peripartum mental illness - p. 63 8. Chapter 6: The hypothalamo–pituitary–adrenal axis and the autonomic nervous system in burnout - p. 83 9. Chapter 7: Posterior hypothalamus as a target in the treatment of aggression: From lesioning to deep brain stimulation - p. 95 10. Chapter 8: The implications of hypothalamic abnormalities for schizophrenia - p. 107 11. Chapter 9: The promiscuity of the oxytocin–vasopressin systems and their involvement in autism spectrum disorder - p. 121 12. Section 23: Epilepsy - p. 140 13. Chapter 10: Gelastic seizures and the hypothalamic hamartoma syndrome: Epileptogenesis beyond the lesion? - p. 143 14. Chapter 11: The interactions between reproductive hormones and epilepsy - p. 155 15. Section 24: Neurodegenerative disorders - p. 174 16. Chapter 12: Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor α isoforms in the hypothalamus - p. 177 17. Chapter 13: Cholinergic neurodegeneration in Alzheimer disease mouse models - p. 201 18. Chapter 14: Autonomic disorders in Parkinson disease: Disrupted hypothalamic connectivity as revealed from resting-state functional magnetic resonance imaging - p. 211 19. Chapter 15: Hypothalamic α-synuclein and its relation to autonomic symptoms and neuroendocrine abnormalities in Parkinson disease - p. 223 20. Chapter 16: Lewy bodies in the olfactory system and the hypothalamus - p. 235 21. Chapter 17: Hypothalamic pathology in Huntington disease - p. 245 22. Chapter 18: Endocrine dysfunction in adrenoleukodystrophy - p. 257 23. Chapter 19: Hypothalamic symptoms of frontotemporal dementia disorders - p. 269 24. Section 25: Olfactory system - p. 280 25. Chapter 20: The vomeronasal organ: History, development, morphology, and functional neuroanatomy - p. 283 26. Chapter 21: Pheromone effects on the human hypothalamus in relation to sexual orientation and gender - p. 293 27. Chapter 22: Kallmann syndrome and idiopathic hypogonadotropic hypogonadism: The role of semaphorin signaling on GnRH neurons - p. 307 28. Chapter 23: Olfaction as an early marker of Parkinson's disease and Alzheimer's disease - p. 317 29. Section 26: Autonomic and sleep disorders - p. 329 30. Chapter 24: The hypothalamus and its role in hypertension - p. 333 31. Chapter 25: The heart is lost without the hypothalamus - p. 355 32. Chapter 26: Sleep disorders and the hypothalamus - p. 369 33. Section 27: Addiction and pain - p. 385 34. Chapter 27: Molecular genetics of neurotransmitters and neuropeptides involved in Internet use disorders including first insights on a potential role of hypothalamus’ oxytocin hormone - p. 389 35. Chapter 28: The neurobiology of cluster headache - p. 401 36. Section 28: Critical care and brain-death - p. 414 37. Chapter 29: Endocrine interventions in the intensive care unit - p. 417 38. Chapter 30: Hypothalamic function in patients diagnosed as brain dead and its practical consequences - p. 433 39. Index - p. 446
