The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.
Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.
The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.
1. Cover image - p. c 2. Series Page - p. i 3. Title page - p. ii 4. Copyright - p. iii 5. Contents - p. v 6. Contributors - p. ix 7. Preface - p. xi 8. 1. Overview of matrix metalloproteinases (MMPs) in health and disease - p. 1 9. 2. Activity-based probes to detect MMP activity - p. 37 10. 3. Classical MMP inhibitors - p. 75 11. 4. Matrix metalloproteinase-13 selective inhibitors - p. 101 12. 5. Tissue inhibitors of metalloproteinases (TIMPs) - p. 135 13. 6. MMPs in oral diseases - p. 169 14. 7. Matrix metalloproteinases (MMPs) in neurodegenerative diseases, an updated overview of the role of MT1-MMP and MT5-MMP in Alzheimer’s disease - p. 209 15. 8. Role of MMPs in neutrophil biology - p. 243 16. 9. Remodeling at the intersection of time and tissue: Aging, obesity, and the MT1-MMP proteolytic driver in ovarian cancer - p. 281 17. 10. Challenges and opportunities in the drug design and pharmacological applications of MMP inhibitors - p. 317
The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.
Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.
The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.
1. Cover image - p. c 2. Series Page - p. i 3. Title page - p. ii 4. Copyright - p. iii 5. Contents - p. v 6. Contributors - p. ix 7. Preface - p. xi 8. 1. Overview of matrix metalloproteinases (MMPs) in health and disease - p. 1 9. 2. Activity-based probes to detect MMP activity - p. 37 10. 3. Classical MMP inhibitors - p. 75 11. 4. Matrix metalloproteinase-13 selective inhibitors - p. 101 12. 5. Tissue inhibitors of metalloproteinases (TIMPs) - p. 135 13. 6. MMPs in oral diseases - p. 169 14. 7. Matrix metalloproteinases (MMPs) in neurodegenerative diseases, an updated overview of the role of MT1-MMP and MT5-MMP in Alzheimer’s disease - p. 209 15. 8. Role of MMPs in neutrophil biology - p. 243 16. 9. Remodeling at the intersection of time and tissue: Aging, obesity, and the MT1-MMP proteolytic driver in ovarian cancer - p. 281 17. 10. Challenges and opportunities in the drug design and pharmacological applications of MMP inhibitors - p. 317
