The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders.
This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Preface - p. iii 7. Acknowledgments - p. iii 8. List of Contributors - p. xi 9. Chapter 1. Molecular Basis of Neurological Disorders - p. 1 10. Chapter 2. Immunological Genes Expression in the Aged Brain - p. 15 11. Chapter 3. Genetic Aspects of Early-Onset Alzheimer’s Disease - p. 29 12. Chapter 4. Role of Neuroinflammation in Neurodegenerative Disorders - p. 41 13. Chapter 5. Interconnectivity of Gene, Immune System, and Metabolism in the Muscle Pathology of Duchenne Muscular Dystrophy (DMD) - p. 51 14. Chapter 6. Viral and Host Cellular Factors Used by Neurotropic Viruses - p. 75 15. Chapter 7. Neurooncogenesis in the Development of Neuroectodermal Cancers - p. 85 16. Chapter 8. Neurological Diseases and Mitochondrial Genes - p. 97 17. Chapter 9. Viral Genes in Neurological Disorders - p. 111 18. Chapter 10. A Gene Map of Brain Injury Disorders - p. 123 19. Chapter 11. Immunogenetics in Migraine - p. 135 20. Chapter 12. Immunogenetics of Neuropathy Disease - p. 149 21. Index - p. 159
The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders.
This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Preface - p. iii 7. Acknowledgments - p. iii 8. List of Contributors - p. xi 9. Chapter 1. Molecular Basis of Neurological Disorders - p. 1 10. Chapter 2. Immunological Genes Expression in the Aged Brain - p. 15 11. Chapter 3. Genetic Aspects of Early-Onset Alzheimer’s Disease - p. 29 12. Chapter 4. Role of Neuroinflammation in Neurodegenerative Disorders - p. 41 13. Chapter 5. Interconnectivity of Gene, Immune System, and Metabolism in the Muscle Pathology of Duchenne Muscular Dystrophy (DMD) - p. 51 14. Chapter 6. Viral and Host Cellular Factors Used by Neurotropic Viruses - p. 75 15. Chapter 7. Neurooncogenesis in the Development of Neuroectodermal Cancers - p. 85 16. Chapter 8. Neurological Diseases and Mitochondrial Genes - p. 97 17. Chapter 9. Viral Genes in Neurological Disorders - p. 111 18. Chapter 10. A Gene Map of Brain Injury Disorders - p. 123 19. Chapter 11. Immunogenetics in Migraine - p. 135 20. Chapter 12. Immunogenetics of Neuropathy Disease - p. 149 21. Index - p. 159
