The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.
Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.
1. The multitasking molecular chaperone Hsp60 - p. vii 2. Cover - p. vii 3. Title Page - p. vii 4. Copyright Page - p. viii 5. Table of Contents - p. viii 6. Contributors - p. xi 7. Preface - p. xiii 8. Chapter One The chaperone system and its diseases - p. 1 9. Chapter Two Physical and biochemical properties of the molecular chaperone Hsp60 - p. 17 10. Chapter Three The spectrum of human Hsp60 genetic variants and associated chaperonopathies - p. 41 11. Chapter Four Hsp60 in inflammation and autoimmunity - p. 77 12. Chapter Five Hsp60 and carcinogenesis - p. 99 13. Chapter Six Hsp60 involvement in articular cartilage tissue homeostasis and pathogenesis - p. 121 14. Chapter Seven Hsp60 and skeletal muscle diseases - p. 149 15. Chapter Eight Hsp60 and cardiovascular diseases - p. 165 16. Chapter Nine Hsp60 in physiology and pathophysiology of the respiratory system - p. 179 17. Chapter Ten Hsp60 and diseases of the digestive system - p. 199 18. Chapter Eleven The chaperone system and the pathophysiology of the urogenital apparatus - p. 213 19. Chapter Twelve Hsp60 and nervous system development and diseases - p. 237 20. Chapter Thirteen Hsp60 and pathophysiology of the neuroendocrine system - p. 263 21. Chapter Fourteen Hsp60 and artificial intelligence - p. 275 22. Appendix I: Supplementary material for Chapter 3 - p. 281 23. Appendix II: Late-breaking news - p. 295 24. Index - p. 305
The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.
Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.
1. The multitasking molecular chaperone Hsp60 - p. vii 2. Cover - p. vii 3. Title Page - p. vii 4. Copyright Page - p. viii 5. Table of Contents - p. viii 6. Contributors - p. xi 7. Preface - p. xiii 8. Chapter One The chaperone system and its diseases - p. 1 9. Chapter Two Physical and biochemical properties of the molecular chaperone Hsp60 - p. 17 10. Chapter Three The spectrum of human Hsp60 genetic variants and associated chaperonopathies - p. 41 11. Chapter Four Hsp60 in inflammation and autoimmunity - p. 77 12. Chapter Five Hsp60 and carcinogenesis - p. 99 13. Chapter Six Hsp60 involvement in articular cartilage tissue homeostasis and pathogenesis - p. 121 14. Chapter Seven Hsp60 and skeletal muscle diseases - p. 149 15. Chapter Eight Hsp60 and cardiovascular diseases - p. 165 16. Chapter Nine Hsp60 in physiology and pathophysiology of the respiratory system - p. 179 17. Chapter Ten Hsp60 and diseases of the digestive system - p. 199 18. Chapter Eleven The chaperone system and the pathophysiology of the urogenital apparatus - p. 213 19. Chapter Twelve Hsp60 and nervous system development and diseases - p. 237 20. Chapter Thirteen Hsp60 and pathophysiology of the neuroendocrine system - p. 263 21. Chapter Fourteen Hsp60 and artificial intelligence - p. 275 22. Appendix I: Supplementary material for Chapter 3 - p. 281 23. Appendix II: Late-breaking news - p. 295 24. Index - p. 305
