The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms.
Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xxiii 6. Preface - p. xxvii 7. Part I: General Aspects, Features of Ill Health and Setting the Scene - p. xxviii 8. Chapter 1. The Nervous System: A Starter Pack for Beginners - p. 3 9. Chapter 2. Sex Differences in the Effects and Actions of Cocaine - p. 11 10. Chapter 3. Contribution of Stress to Cocaine Addiction - p. 21 11. Chapter 4. Strokes Associated With Cocaine Use - p. 31 12. Chapter 5. Concentrations of Cocaine in Blood Samples From Impaired Drivers and Drug-Related Deaths - p. 39 13. Chapter 6. Cocaine Postmortem Distribution in Brain - p. 49 14. Chapter 7. Cocaine Adulterants and Effects on Monoamine Transporters - p. 59 15. Chapter 8. Global Approaches in the Analysis of Cocaine-Induced Gene Expression - p. 69 16. Part II: Molecular Effects - p. 76 17. Chapter 9. Cocaine and Epigenetics: An Overview - p. 81 18. Chapter 10. DNA Methylation, Psychostimulant-Induced Addiction and the Position of Cocaine - p. 89 19. Chapter 11. MicroRNAs and Cocaine - p. 97 20. Chapter 12. Cocaine and Transcription Factors - p. 107 21. Chapter 13. Cocaine and Posttranslational Modifications of Neuronal Proteins - p. 125 22. Chapter 14. Use of Knock-In Mice to Investigate the Molecular Mechanism of Cocaine Action - p. 135 23. Chapter 15. Mechanisms That Regulate the Expression of Dopamine D1 Receptor in Cocaine Addiction - p. 143 24. Part III: Cellular Effects - p. 150 25. Chapter 16. Critical Role of D-Serine Signaling in Synaptic Plasticity Relevant to Cocaine Addiction - p. 155 26. Chapter 17. Neurological Aspects of Cocaine and the Suprachiasmatic Circadian Clock - p. 163 27. Chapter 18. The Proteomics of Cocaine in the Nucleus Accumbens - p. 173 28. Chapter 19. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors - p. 183 29. Chapter 20. Teneurin C-Terminal Associated Peptide (TCAP)-1 and Corticotropin-Releasing Factor (CRF) Interactions in the Modulation of Cocaine-Related Behavior - p. 195 30. Chapter 21. Role of Mitochondria on the Neurological Effects of Cocaine - p. 205 31. Chapter 22. Cocaine and Brain Acid-Sensing Ion Channels - p. 219 32. Chapter 23. Oxytocin’s Effects in Cocaine and Other Psychostimulant Addictions - p. 227 33. Chapter 24. Hypocretin (Orexin) in Models of Cocaine Addiction - p. 235 34. Chapter 25. Prenatal Cocaine-Induced Alterations in Dendritic Spine Density and Glutamate Neurotransmission - p. 247 35. Part IV: Regional, Structural, and Imaging Aspects - p. 254 36. Chapter 26. The Role of the Hippocampus in Cocaine Responses - p. 259 37. Chapter 27. Cocaine Addiction and mGluR5: Recent Advances From Behavioral and Positron Emission Tomography Studies - p. 269 38. Chapter 28. Cocaine, Ghrelin, and the Mesolimbic System - p. 279 39. Chapter 29. Mesolimbic Dopamine Signaling in Cocaine Addiction - p. 287 40. Chapter 30. Cocaine and Striatal Projection Neuron Subtype Mechanisms - p. 297 41. Chapter 31. Leukoencephalopathy and the Use of Cocaine - p. 307 42. Chapter 32. The Role of the Habenulomesencephalic Circuit in Cocaine Addiction - p. 313 43. Chapter 33. Crack Cocaine and Cognitive Related Electrophysiological Changes After Noninvasive Brain Stimulation - p. 321 44. Chapter 34. Stroop, Cocaine Dependence, and Intrinsic Connectivity - p. 331 45. Part V: Behavioral Aspects - p. 337 46. Chapter 35. Very Long-Term Effects of Chronic Cocaine on Anxiety and Stress - p. 343 47. Chapter 36. Long-Lasting Changes Following Repeated Cocaine Use: Behavioral Sensitization and Neurotoxicity - p. 353 48. Chapter 37. Headache in Cocaine Users: Epidemiology, Clinical Features, and Putative Pathophysiological Mechanisms - p. 363 49. Chapter 38. Cocaine and Intertemporal Decision-Making - p. 375 50. Chapter 39. Cocaine Dependence and Attention Deficit Hyperactivity Disorder - p. 383 51. Chapter 40. Cognitive Dysfunctions in Chronic Cocaine Users - p. 395 52. Chapter 41. Cocaine-Seeking Behavior: Comparisons to Food-Seeking Behavior and Potential Treatments - p. 407 53. Chapter 42. Impact of Prenatal Cocaine Exposure on Adolescent Behavior - p. 417 54. Part VI: Receptors, Transporters, and Neuropharmacology - p. 424 55. Chapter 43. Cocaine Addiction and Adenosine A1 and A2A Receptors - p. 429 56. Chapter 44. Cocaine and 5-HT1B Receptor-Induced Long-Term Depression - p. 439 57. Chapter 45. Hippocampal Contributions to Dopamine Receptor-Mediated Effects of Cocaine - p. 449 58. Chapter 46. The Role of Dopamine D3 Receptors in Cocaine-Related Behavior - p. 461 59. Chapter 47. Cocaine, β-Endorphin, and δ-Opioid Receptors - p. 471 60. Chapter 48. Trace Amine-Associated Receptor 1 and Cocaine Abuse - p. 483 61. Chapter 49. Cocaine and Cerebral Sigma-1 Receptor Occupancy - p. 491 62. Chapter 50. The Glutamate Transporter GLT1 and Cocaine Relapse - p. 501 63. Chapter 51. Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels - p. 511 64. Chapter 52. Cocaine-Induced Metaplasticity in the CA1 Region of the Hippocampus - p. 519 65. Chapter 53. Interaction of Cocaine Analogue RTI82 With the Dopamine Transporter - p. 527 66. Chapter 54. Cocaine and Dysregulated Synaptic Transmission in the Bed Nucleus of the Stria Terminalis - p. 537 67. Part VII: Withdrawal and Abstinence - p. 541 68. Chapter 55. Ventromedial Prefrontal Cortex Glutamate and Cocaine-Craving During Abstinence - p. 547 69. Chapter 56. Brain-Derived Neurotrophic Factor in Cocaine Withdrawal - p. 555 70. Part VIII: Poly-Drug Use and Comorbidities - p. 562 71. Chapter 57. Comorbidities Associated With the Use and Misuse of Crack Cocaine - p. 567 72. Chapter 58. Nicotine and Cocaine Interactions: Focus on Dopamine Pharmacology, Neuroadaptations, and Behavior Relevant to Addiction - p. 577 73. Chapter 59. Pharmacological Treatments for Alcohol–Cocaine Interactions: A Preclinical Focus - p. 587 74. Part IX: Assessment and Treatment Aspects - p. 593 75. Chapter 60. A Review of Instruments for Screening and Diagnosis of Cocaine Use - p. 599 76. Chapter 61. Toxicological Analysis for Cocaine Use - p. 609 77. Chapter 62. Cocaine and an Overview of Neurocognitive Relapse Predictors - p. 617 78. Chapter 63. Medication Strategies for the Management of Cocaine Use Disorder - p. 627 79. Chapter 64. Antipsychotic Drugs in Cocaine Use Disorder - p. 639 80. Chapter 65. Use of N-Acetylcysteine in Relapse and Cocaine Addiction - p. 645 81. Chapter 66. Biperiden in the Treatment of Cocaine/Crack Dependence: Clinical Perspectives - p. 655 82. Chapter 67. Actions of Butyrylcholinesterase Against Cocaine - p. 663 83. Chapter 68. Cocaine and Butyrylcholinesterase Gene Therapy - p. 673 84. Chapter 69. Patient Responses to Guanfacine in Cocaine Addiction - p. 679 85. Chapter 70. Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction - p. 689 86. Chapter 71. Negative Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 for the Treatment of Cocaine Use Disorder - p. 699 87. Chapter 72. Treating Cocaine Addiction With Motivational Interviewing - p. 711 88. Part X: Resources - p. 718 89. Recommended Research and Resources on the Neuroscience of Cocaine: Mechanisms and Treatment - p. 723 90. Index - p. 727
The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms.
Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xxiii 6. Preface - p. xxvii 7. Part I: General Aspects, Features of Ill Health and Setting the Scene - p. xxviii 8. Chapter 1. The Nervous System: A Starter Pack for Beginners - p. 3 9. Chapter 2. Sex Differences in the Effects and Actions of Cocaine - p. 11 10. Chapter 3. Contribution of Stress to Cocaine Addiction - p. 21 11. Chapter 4. Strokes Associated With Cocaine Use - p. 31 12. Chapter 5. Concentrations of Cocaine in Blood Samples From Impaired Drivers and Drug-Related Deaths - p. 39 13. Chapter 6. Cocaine Postmortem Distribution in Brain - p. 49 14. Chapter 7. Cocaine Adulterants and Effects on Monoamine Transporters - p. 59 15. Chapter 8. Global Approaches in the Analysis of Cocaine-Induced Gene Expression - p. 69 16. Part II: Molecular Effects - p. 76 17. Chapter 9. Cocaine and Epigenetics: An Overview - p. 81 18. Chapter 10. DNA Methylation, Psychostimulant-Induced Addiction and the Position of Cocaine - p. 89 19. Chapter 11. MicroRNAs and Cocaine - p. 97 20. Chapter 12. Cocaine and Transcription Factors - p. 107 21. Chapter 13. Cocaine and Posttranslational Modifications of Neuronal Proteins - p. 125 22. Chapter 14. Use of Knock-In Mice to Investigate the Molecular Mechanism of Cocaine Action - p. 135 23. Chapter 15. Mechanisms That Regulate the Expression of Dopamine D1 Receptor in Cocaine Addiction - p. 143 24. Part III: Cellular Effects - p. 150 25. Chapter 16. Critical Role of D-Serine Signaling in Synaptic Plasticity Relevant to Cocaine Addiction - p. 155 26. Chapter 17. Neurological Aspects of Cocaine and the Suprachiasmatic Circadian Clock - p. 163 27. Chapter 18. The Proteomics of Cocaine in the Nucleus Accumbens - p. 173 28. Chapter 19. Cocaine, Protein Kinase, and Phosphorylation of Neuronal Receptors - p. 183 29. Chapter 20. Teneurin C-Terminal Associated Peptide (TCAP)-1 and Corticotropin-Releasing Factor (CRF) Interactions in the Modulation of Cocaine-Related Behavior - p. 195 30. Chapter 21. Role of Mitochondria on the Neurological Effects of Cocaine - p. 205 31. Chapter 22. Cocaine and Brain Acid-Sensing Ion Channels - p. 219 32. Chapter 23. Oxytocin’s Effects in Cocaine and Other Psychostimulant Addictions - p. 227 33. Chapter 24. Hypocretin (Orexin) in Models of Cocaine Addiction - p. 235 34. Chapter 25. Prenatal Cocaine-Induced Alterations in Dendritic Spine Density and Glutamate Neurotransmission - p. 247 35. Part IV: Regional, Structural, and Imaging Aspects - p. 254 36. Chapter 26. The Role of the Hippocampus in Cocaine Responses - p. 259 37. Chapter 27. Cocaine Addiction and mGluR5: Recent Advances From Behavioral and Positron Emission Tomography Studies - p. 269 38. Chapter 28. Cocaine, Ghrelin, and the Mesolimbic System - p. 279 39. Chapter 29. Mesolimbic Dopamine Signaling in Cocaine Addiction - p. 287 40. Chapter 30. Cocaine and Striatal Projection Neuron Subtype Mechanisms - p. 297 41. Chapter 31. Leukoencephalopathy and the Use of Cocaine - p. 307 42. Chapter 32. The Role of the Habenulomesencephalic Circuit in Cocaine Addiction - p. 313 43. Chapter 33. Crack Cocaine and Cognitive Related Electrophysiological Changes After Noninvasive Brain Stimulation - p. 321 44. Chapter 34. Stroop, Cocaine Dependence, and Intrinsic Connectivity - p. 331 45. Part V: Behavioral Aspects - p. 337 46. Chapter 35. Very Long-Term Effects of Chronic Cocaine on Anxiety and Stress - p. 343 47. Chapter 36. Long-Lasting Changes Following Repeated Cocaine Use: Behavioral Sensitization and Neurotoxicity - p. 353 48. Chapter 37. Headache in Cocaine Users: Epidemiology, Clinical Features, and Putative Pathophysiological Mechanisms - p. 363 49. Chapter 38. Cocaine and Intertemporal Decision-Making - p. 375 50. Chapter 39. Cocaine Dependence and Attention Deficit Hyperactivity Disorder - p. 383 51. Chapter 40. Cognitive Dysfunctions in Chronic Cocaine Users - p. 395 52. Chapter 41. Cocaine-Seeking Behavior: Comparisons to Food-Seeking Behavior and Potential Treatments - p. 407 53. Chapter 42. Impact of Prenatal Cocaine Exposure on Adolescent Behavior - p. 417 54. Part VI: Receptors, Transporters, and Neuropharmacology - p. 424 55. Chapter 43. Cocaine Addiction and Adenosine A1 and A2A Receptors - p. 429 56. Chapter 44. Cocaine and 5-HT1B Receptor-Induced Long-Term Depression - p. 439 57. Chapter 45. Hippocampal Contributions to Dopamine Receptor-Mediated Effects of Cocaine - p. 449 58. Chapter 46. The Role of Dopamine D3 Receptors in Cocaine-Related Behavior - p. 461 59. Chapter 47. Cocaine, β-Endorphin, and δ-Opioid Receptors - p. 471 60. Chapter 48. Trace Amine-Associated Receptor 1 and Cocaine Abuse - p. 483 61. Chapter 49. Cocaine and Cerebral Sigma-1 Receptor Occupancy - p. 491 62. Chapter 50. The Glutamate Transporter GLT1 and Cocaine Relapse - p. 501 63. Chapter 51. Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels - p. 511 64. Chapter 52. Cocaine-Induced Metaplasticity in the CA1 Region of the Hippocampus - p. 519 65. Chapter 53. Interaction of Cocaine Analogue RTI82 With the Dopamine Transporter - p. 527 66. Chapter 54. Cocaine and Dysregulated Synaptic Transmission in the Bed Nucleus of the Stria Terminalis - p. 537 67. Part VII: Withdrawal and Abstinence - p. 541 68. Chapter 55. Ventromedial Prefrontal Cortex Glutamate and Cocaine-Craving During Abstinence - p. 547 69. Chapter 56. Brain-Derived Neurotrophic Factor in Cocaine Withdrawal - p. 555 70. Part VIII: Poly-Drug Use and Comorbidities - p. 562 71. Chapter 57. Comorbidities Associated With the Use and Misuse of Crack Cocaine - p. 567 72. Chapter 58. Nicotine and Cocaine Interactions: Focus on Dopamine Pharmacology, Neuroadaptations, and Behavior Relevant to Addiction - p. 577 73. Chapter 59. Pharmacological Treatments for Alcohol–Cocaine Interactions: A Preclinical Focus - p. 587 74. Part IX: Assessment and Treatment Aspects - p. 593 75. Chapter 60. A Review of Instruments for Screening and Diagnosis of Cocaine Use - p. 599 76. Chapter 61. Toxicological Analysis for Cocaine Use - p. 609 77. Chapter 62. Cocaine and an Overview of Neurocognitive Relapse Predictors - p. 617 78. Chapter 63. Medication Strategies for the Management of Cocaine Use Disorder - p. 627 79. Chapter 64. Antipsychotic Drugs in Cocaine Use Disorder - p. 639 80. Chapter 65. Use of N-Acetylcysteine in Relapse and Cocaine Addiction - p. 645 81. Chapter 66. Biperiden in the Treatment of Cocaine/Crack Dependence: Clinical Perspectives - p. 655 82. Chapter 67. Actions of Butyrylcholinesterase Against Cocaine - p. 663 83. Chapter 68. Cocaine and Butyrylcholinesterase Gene Therapy - p. 673 84. Chapter 69. Patient Responses to Guanfacine in Cocaine Addiction - p. 679 85. Chapter 70. Cannabinoid CB2 Receptor: A New Target for Treatment of Cocaine Addiction - p. 689 86. Chapter 71. Negative Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 for the Treatment of Cocaine Use Disorder - p. 699 87. Chapter 72. Treating Cocaine Addiction With Motivational Interviewing - p. 711 88. Part X: Resources - p. 718 89. Recommended Research and Resources on the Neuroscience of Cocaine: Mechanisms and Treatment - p. 723 90. Index - p. 727
