Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.
Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.
Diagnosis and Treatment of Traumatic Brain Injury:
Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Front Matter for Volume 1 - p. i 5. Copyright for Volume 1 - p. iv 6. Dedication for Volume 1 - p. v 7. Contributors for Volume 1 - p. xix 8. Preface for Volume 1 - p. xxv 9. Front Matter for Volume 2 - p. xxvi 10. Copyright for Volume 2 - p. xxvi 11. Dedication for Volume 2 - p. xxvi 12. Contributors for Volume 2 - p. xxvi 13. Preface for Volume 2 - p. xxvi 14. Volume 1: Diagnosis and Treatment of Traumatic Brain Injury - p. xxvi 15. Section A: Setting the scene and introductory chapters - p. xxvi 16. Chapter 1: Traumatic brain injury and in-hospital mortality- CT perfusion and beyond - p. 3 17. Chapter 2: Predictors of outcome in moderate and severe traumatic brain injury - p. 15 18. Chapter 3: Thirty years post-injury: Impact of traumatic brain injury on later Alzheimer’s disease - p. 27 19. Chapter 4: Drug interventions and stem cells in traumatic brain injury: Translation from experimental model to bedside - p. 39 20. Chapter 5: Management of traumatic brain injury from the aspect of emergency department and case studies - p. 57 21. Chapter 6: Neuropsychiatric disorders after severe traumatic brain injury: An overview - p. 71 22. Section B: Clinical features of traumatic brain injury - p. 83 23. Chapter 7: Cerebral hemorrhages in traumatic brain injury - p. 87 24. Chapter 8: Linking fibrinogen, coagulopathy prophylaxis, and traumatic brain injury - p. 101 25. Chapter 9: Linking traumatic brain injury and nosocomial infections - p. 111 26. Chapter 10: Long-term sequelae of mild-repetitive and severe traumatic brain injury: Clinical manifestations, neuropathology and diagnosis by tau PET imaging - p. 123 27. Chapter 11: Evaluating the integrity of white matter after traumatic brain injury and the utility of diffusion tensor imaging - p. 137 28. Chapter 12: Cerebral activation of attention and working memory in traumatic brain injury - p. 151 29. Chapter 13: Traumatic brain injury: Linking intracranial pressure, arterial pressure, and the pressure reactivity index - p. 169 30. Chapter 14: Cerebral perfusion pressure thresholds in traumatic brain injury - p. 181 31. Chapter 15: Brain swelling in traumatic brain injury - p. 191 32. Chapter 16: Post-coma syndrome in the context of severe acquired brain injury: Traumatic brain injury and beyond - p. 205 33. Section C: Diagnosis and evaluation - p. 219 34. Chapter 17: Features of the World Health Organization Disability Assessment Schedule 2.0 and its applications for traumatic brain injury assessment - p. 223 35. Chapter 18: Biomarkers in pediatric traumatic injury: The brain and beyond - p. 233 36. Chapter 19: Brain injury biomarkers: Proteins and autoantibodies interplay - p. 239 37. Chapter 20: Chitinase-3-like protein 1: Features and applications as a biomarker in traumatic brain injury - p. 251 38. Chapter 21: microRNA biomarkers in traumatic brain injury: A new narrative - p. 277 39. Chapter 22: Pediatric minor head injury imaging - p. 289 40. Chapter 23: Transcranial Doppler ultrasound in acute traumatic brain injury - p. 301 41. Chapter 24: Computed tomography assessment of brain swelling - p. 315 42. Chapter 25: Machine learning and prediction of traumatic brain injury mortality - p. 327 43. Chapter 26: Pituitary dysfunction after traumatic brain injury: A focus on screening, diagnosis, and treatment - p. 339 44. Section D: Treatments: Experimental and clinical - p. 353 45. Chapter 27: European aspects of guidelines used in traumatic brain injury - p. 357 46. Chapter 28: Anesthesia in traumatic brain injury - p. 367 47. Chapter 29: Treatment of raised intracranial pressure in traumatic head injury - p. 379 48. Chapter 30: Seizures after traumatic brain injury and their treatment - p. 397 49. Chapter 31: Neurosurgical treatment of critical brain damage: The early post-surgical period and algorithms - p. 411 50. Chapter 32: Hypertonic saline usage in traumatic brain injury: A focus on pediatrics - p. 421 51. Chapter 33: Treatment of vascular lesions in traumatic brain injury - p. 437 52. Chapter 34: Airway pressure release ventilation (APRV) in traumatic brain injury - p. 449 53. Chapter 35: Linking death, the paranasal sinuses, and traumatic head trauma - p. 455 54. Chapter 36: Cannabidiol in traumatic brain injury - p. 463 55. Chapter 37: Valproic acid: A new narrative on its features and effects in traumatic brain injury - p. 477 56. Chapter 38: Dietary supplementation for traumatic brain injury - p. 485 57. Section E: Rehabilitation in traumatic brain injury - p. 494 58. Chapter 39: Virtual reality and cognitive rehabilitation after traumatic brain injury - p. 497 59. Chapter 40: How the elderly and young compare in response to traumatic brain injury rehabilitation - p. 507 60. Chapter 41: Rehabilitation of social cognition after traumatic brain injury - p. 517 61. Chapter 42: Psycho-educational intervention on caregivers within the rehabilitation process: From the post-acute to the homecoming phases - p. 531 62. Chapter 43: Recommended resources and sites for the neuroscience of traumatic brain injury - p. 543 63. Volume 2: Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury - p. 554 64. Section A: Setting the scene: The spectrum of traumatic brain injuries - p. 554 65. Chapter 1: Fall-related traumatic brain injuries in older adults: The role of the neck - p. 554 66. Chapter 2: The implications of sex and gender in traumatic brain injury - p. 554 67. Chapter 3: Sport-related concussion: The role of repetitive head impact exposure - p. 554 68. Chapter 4: Traumatic brain injury and molecular biology: A new narrative - p. 554 69. Chapter 5: Features of decompressive craniectomy in traumatic brain injury: History, effects, management, and new trends - p. 554 70. Chapter 6: Management of traumatic brain injury in accordance with contemporary guidelines: Treatment, monitoring, and thresholds - p. 554 71. Section B: Cellular and molecular aspects of traumatic brain injury - p. 554 72. Chapter 7: Insights into the pathological role of neuroinflammatory responses in traumatic brain injury - p. 554 73. Chapter 8: Seizures in traumatic brain injury: A focus on cellular aspects - p. 554 74. Chapter 9: Linking traumatic brain injury, neural stem, and progenitor cells - p. 554 75. Chapter 10: Microglia in traumatic brain injury - p. 554 76. Chapter 11: Dendritic spine plasticity and traumatic brain injury - p. 554 77. Chapter 12: Aging, the immune response, and traumatic brain injury - p. 554 78. Chapter 13: The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes - p. 554 79. Chapter 14: The role of regulatory T cells in traumatic brain injury - p. 554 80. Chapter 15: The role of the chemokine prokineticin 2 in traumatic brain injury - p. 554 81. Chapter 16: The role of Na+,K+-ATPase on TBI-induced physiopathology - p. 554 82. Chapter 17: Pyruvate dehydrogenase complex, metabolic enzymes, and energy derangement in traumatic brain injury - p. 554 83. Chapter 18: Angiopoietin-1/Tie-2 signaling in traumatic brain injury - p. 554 84. Chapter 19: Brain microdialysis and applications to drug therapy in severe traumatic brain injury - p. 554 85. Chapter 20: Comparing radiation and traumatic brain injuries: New insights - p. 554 86. Chapter 21: Sodium dysregulation in traumatic brain injury - p. 554 87. Chapter 22: WNT genes and their roles in traumatic brain injury - p. 554 88. Section C: Physiological and metabolic effects - p. 554 89. Chapter 23: Circuit reorganization after diffuse axonal injury: Utility of the whisker barrel circuit - p. 554 90. Chapter 24: Neuroendocrine abnormalities following traumatic brain injury - p. 554 91. Chapter 25: Thyroid hormone actions in traumatic brain injury - p. 554 92. Chapter 26: Testosterone: Features and role in treating traumatic brain injury - p. 554 93. Chapter 27: The rate of empty sella (ES) in traumatic brain injury: Links with endocrine profiles - p. 554 94. Chapter 28: Traumatic brain injury: Inter-relationship with sleep - p. 554 95. Chapter 29: Puberty and traumatic brain injury - p. 554 96. Chapter 30: Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury - p. 554 97. Chapter 31: Imaging connectivity and functional brain networks in mild traumatic brain injury - p. 554 98. Chapter 32: Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory - p. 554 99. Chapter 33: Monitoring real-time changes in physiology: Multi-modality neurologic monitoring for pediatric traumatic brain injury - p. 554 100. Chapter 34: Blood gas, arterial, and end-tidal carbon dioxide in traumatic brain injury - p. 554 101. Chapter 35: Disturbances of cerebral microcirculation in traumatic brain injury: The role of changes in microcirculatory biomarkers - p. 554 102. Section D: Behavioral and psychological aspects - p. 554 103. Chapter 36: Social cognition in traumatic brain injury - p. 554 104. Chapter 37: Physical exercise: Effects on cognitive function after traumatic brain injury - p. 554 105. Chapter 38: Traumatic axonal injury as a key driver of the relationship between traumatic brain injury, cognitive dysfunction, and dementia - p. 554 106. Chapter 39: Neuropsychological functioning of children and youth after traumatic brain injury - p. 554 107. Chapter 40: Behavioral effects of traumatic brain injury: Use of guanosine - p. 554 108. Chapter 41: Recognizing emotions and effects of traumatic brain injury - p. 554 109. Chapter 42: Cognitive communication connections and higher-level language with traumatic brain-injured population - p. 554 110. Chapter 43: Self-awareness after severe traumatic brain injury: From impairment of self-awareness to psychological adjustment - p. 554 111. Chapter 44: Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies - p. 554 112. Chapter 45: The link between sleep and quality of life in childhood traumatic brain injury - p. 554 113. Index for Volume 1 - p. 555 114. Index for Volume 2 - p. 564
Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.
Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.
Diagnosis and Treatment of Traumatic Brain Injury:
Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Front Matter for Volume 1 - p. i 5. Copyright for Volume 1 - p. iv 6. Dedication for Volume 1 - p. v 7. Contributors for Volume 1 - p. xix 8. Preface for Volume 1 - p. xxv 9. Front Matter for Volume 2 - p. xxvi 10. Copyright for Volume 2 - p. xxvi 11. Dedication for Volume 2 - p. xxvi 12. Contributors for Volume 2 - p. xxvi 13. Preface for Volume 2 - p. xxvi 14. Volume 1: Diagnosis and Treatment of Traumatic Brain Injury - p. xxvi 15. Section A: Setting the scene and introductory chapters - p. xxvi 16. Chapter 1: Traumatic brain injury and in-hospital mortality- CT perfusion and beyond - p. 3 17. Chapter 2: Predictors of outcome in moderate and severe traumatic brain injury - p. 15 18. Chapter 3: Thirty years post-injury: Impact of traumatic brain injury on later Alzheimer’s disease - p. 27 19. Chapter 4: Drug interventions and stem cells in traumatic brain injury: Translation from experimental model to bedside - p. 39 20. Chapter 5: Management of traumatic brain injury from the aspect of emergency department and case studies - p. 57 21. Chapter 6: Neuropsychiatric disorders after severe traumatic brain injury: An overview - p. 71 22. Section B: Clinical features of traumatic brain injury - p. 83 23. Chapter 7: Cerebral hemorrhages in traumatic brain injury - p. 87 24. Chapter 8: Linking fibrinogen, coagulopathy prophylaxis, and traumatic brain injury - p. 101 25. Chapter 9: Linking traumatic brain injury and nosocomial infections - p. 111 26. Chapter 10: Long-term sequelae of mild-repetitive and severe traumatic brain injury: Clinical manifestations, neuropathology and diagnosis by tau PET imaging - p. 123 27. Chapter 11: Evaluating the integrity of white matter after traumatic brain injury and the utility of diffusion tensor imaging - p. 137 28. Chapter 12: Cerebral activation of attention and working memory in traumatic brain injury - p. 151 29. Chapter 13: Traumatic brain injury: Linking intracranial pressure, arterial pressure, and the pressure reactivity index - p. 169 30. Chapter 14: Cerebral perfusion pressure thresholds in traumatic brain injury - p. 181 31. Chapter 15: Brain swelling in traumatic brain injury - p. 191 32. Chapter 16: Post-coma syndrome in the context of severe acquired brain injury: Traumatic brain injury and beyond - p. 205 33. Section C: Diagnosis and evaluation - p. 219 34. Chapter 17: Features of the World Health Organization Disability Assessment Schedule 2.0 and its applications for traumatic brain injury assessment - p. 223 35. Chapter 18: Biomarkers in pediatric traumatic injury: The brain and beyond - p. 233 36. Chapter 19: Brain injury biomarkers: Proteins and autoantibodies interplay - p. 239 37. Chapter 20: Chitinase-3-like protein 1: Features and applications as a biomarker in traumatic brain injury - p. 251 38. Chapter 21: microRNA biomarkers in traumatic brain injury: A new narrative - p. 277 39. Chapter 22: Pediatric minor head injury imaging - p. 289 40. Chapter 23: Transcranial Doppler ultrasound in acute traumatic brain injury - p. 301 41. Chapter 24: Computed tomography assessment of brain swelling - p. 315 42. Chapter 25: Machine learning and prediction of traumatic brain injury mortality - p. 327 43. Chapter 26: Pituitary dysfunction after traumatic brain injury: A focus on screening, diagnosis, and treatment - p. 339 44. Section D: Treatments: Experimental and clinical - p. 353 45. Chapter 27: European aspects of guidelines used in traumatic brain injury - p. 357 46. Chapter 28: Anesthesia in traumatic brain injury - p. 367 47. Chapter 29: Treatment of raised intracranial pressure in traumatic head injury - p. 379 48. Chapter 30: Seizures after traumatic brain injury and their treatment - p. 397 49. Chapter 31: Neurosurgical treatment of critical brain damage: The early post-surgical period and algorithms - p. 411 50. Chapter 32: Hypertonic saline usage in traumatic brain injury: A focus on pediatrics - p. 421 51. Chapter 33: Treatment of vascular lesions in traumatic brain injury - p. 437 52. Chapter 34: Airway pressure release ventilation (APRV) in traumatic brain injury - p. 449 53. Chapter 35: Linking death, the paranasal sinuses, and traumatic head trauma - p. 455 54. Chapter 36: Cannabidiol in traumatic brain injury - p. 463 55. Chapter 37: Valproic acid: A new narrative on its features and effects in traumatic brain injury - p. 477 56. Chapter 38: Dietary supplementation for traumatic brain injury - p. 485 57. Section E: Rehabilitation in traumatic brain injury - p. 494 58. Chapter 39: Virtual reality and cognitive rehabilitation after traumatic brain injury - p. 497 59. Chapter 40: How the elderly and young compare in response to traumatic brain injury rehabilitation - p. 507 60. Chapter 41: Rehabilitation of social cognition after traumatic brain injury - p. 517 61. Chapter 42: Psycho-educational intervention on caregivers within the rehabilitation process: From the post-acute to the homecoming phases - p. 531 62. Chapter 43: Recommended resources and sites for the neuroscience of traumatic brain injury - p. 543 63. Volume 2: Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury - p. 554 64. Section A: Setting the scene: The spectrum of traumatic brain injuries - p. 554 65. Chapter 1: Fall-related traumatic brain injuries in older adults: The role of the neck - p. 554 66. Chapter 2: The implications of sex and gender in traumatic brain injury - p. 554 67. Chapter 3: Sport-related concussion: The role of repetitive head impact exposure - p. 554 68. Chapter 4: Traumatic brain injury and molecular biology: A new narrative - p. 554 69. Chapter 5: Features of decompressive craniectomy in traumatic brain injury: History, effects, management, and new trends - p. 554 70. Chapter 6: Management of traumatic brain injury in accordance with contemporary guidelines: Treatment, monitoring, and thresholds - p. 554 71. Section B: Cellular and molecular aspects of traumatic brain injury - p. 554 72. Chapter 7: Insights into the pathological role of neuroinflammatory responses in traumatic brain injury - p. 554 73. Chapter 8: Seizures in traumatic brain injury: A focus on cellular aspects - p. 554 74. Chapter 9: Linking traumatic brain injury, neural stem, and progenitor cells - p. 554 75. Chapter 10: Microglia in traumatic brain injury - p. 554 76. Chapter 11: Dendritic spine plasticity and traumatic brain injury - p. 554 77. Chapter 12: Aging, the immune response, and traumatic brain injury - p. 554 78. Chapter 13: The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes - p. 554 79. Chapter 14: The role of regulatory T cells in traumatic brain injury - p. 554 80. Chapter 15: The role of the chemokine prokineticin 2 in traumatic brain injury - p. 554 81. Chapter 16: The role of Na+,K+-ATPase on TBI-induced physiopathology - p. 554 82. Chapter 17: Pyruvate dehydrogenase complex, metabolic enzymes, and energy derangement in traumatic brain injury - p. 554 83. Chapter 18: Angiopoietin-1/Tie-2 signaling in traumatic brain injury - p. 554 84. Chapter 19: Brain microdialysis and applications to drug therapy in severe traumatic brain injury - p. 554 85. Chapter 20: Comparing radiation and traumatic brain injuries: New insights - p. 554 86. Chapter 21: Sodium dysregulation in traumatic brain injury - p. 554 87. Chapter 22: WNT genes and their roles in traumatic brain injury - p. 554 88. Section C: Physiological and metabolic effects - p. 554 89. Chapter 23: Circuit reorganization after diffuse axonal injury: Utility of the whisker barrel circuit - p. 554 90. Chapter 24: Neuroendocrine abnormalities following traumatic brain injury - p. 554 91. Chapter 25: Thyroid hormone actions in traumatic brain injury - p. 554 92. Chapter 26: Testosterone: Features and role in treating traumatic brain injury - p. 554 93. Chapter 27: The rate of empty sella (ES) in traumatic brain injury: Links with endocrine profiles - p. 554 94. Chapter 28: Traumatic brain injury: Inter-relationship with sleep - p. 554 95. Chapter 29: Puberty and traumatic brain injury - p. 554 96. Chapter 30: Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury - p. 554 97. Chapter 31: Imaging connectivity and functional brain networks in mild traumatic brain injury - p. 554 98. Chapter 32: Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory - p. 554 99. Chapter 33: Monitoring real-time changes in physiology: Multi-modality neurologic monitoring for pediatric traumatic brain injury - p. 554 100. Chapter 34: Blood gas, arterial, and end-tidal carbon dioxide in traumatic brain injury - p. 554 101. Chapter 35: Disturbances of cerebral microcirculation in traumatic brain injury: The role of changes in microcirculatory biomarkers - p. 554 102. Section D: Behavioral and psychological aspects - p. 554 103. Chapter 36: Social cognition in traumatic brain injury - p. 554 104. Chapter 37: Physical exercise: Effects on cognitive function after traumatic brain injury - p. 554 105. Chapter 38: Traumatic axonal injury as a key driver of the relationship between traumatic brain injury, cognitive dysfunction, and dementia - p. 554 106. Chapter 39: Neuropsychological functioning of children and youth after traumatic brain injury - p. 554 107. Chapter 40: Behavioral effects of traumatic brain injury: Use of guanosine - p. 554 108. Chapter 41: Recognizing emotions and effects of traumatic brain injury - p. 554 109. Chapter 42: Cognitive communication connections and higher-level language with traumatic brain-injured population - p. 554 110. Chapter 43: Self-awareness after severe traumatic brain injury: From impairment of self-awareness to psychological adjustment - p. 554 111. Chapter 44: Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies - p. 554 112. Chapter 45: The link between sleep and quality of life in childhood traumatic brain injury - p. 554 113. Index for Volume 1 - p. 555 114. Index for Volume 2 - p. 564
