The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This updated edition synthesizes new information at the molecular, cellular and organismal levels, while also presenting modern ovarian physiology in a more understandable and comparative context. The book looks at ovarian function from a detailed molecular and cellular level that examines all phases of the ovarian lifecycle that places special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. iv 6. I: The Ovarian Follicular Apparatus: Operational Characteristics - p. iv 7. Chapter 1: Follicle Selection in Mammalian Ovaries - p. iv 8. Chapter 2: Regulation of Follicle Formation and Development by Ovarian Signaling Pathways - p. 21 9. Chapter 3: Human Folliculogenesis Revisited: The Menstrual Cycle Visualized by Ultrasonography - p. 49 10. Chapter 4: Development of the Mammalian Ovary and Follicles - p. 69 11. Chapter 5: Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism - p. 82 12. Chapter 6: Inhibin, Activin, and Follistatin in Ovarian Physiology - p. 94 13. Chapter 7: Cell-Cell Interactions in Ovarian Follicles: Role of TGF-β Superfamily Members - p. 105 14. Chapter 8: Mutations and Polymorphisms, and Their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes - p. 125 15. Chapter 9: Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease - p. 148 16. II: Oocyte Maturation and Ovulation - p. 154 17. Chapter 10: Mammalian Oogenesis: The Fragile Foundation of the Next Generation - p. 154 18. Chapter 11: Regulation of Mammalian Oocyte Maturation - p. 164 19. Chapter 12: Oocyte Meiotic Maturation - p. 180 20. Chapter 13: Gene Expression During Oogenesis and Oocyte Development - p. 203 21. Chapter 14: Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte Release - p. 216 22. III: The Corpus Luteum - p. 234 23. Chapter 15: Molecular Regulation of Progesterone Production in the Corpus Luteum - p. 234 24. Chapter 16: Corpus Luteum Formation - p. 253 25. Chapter 17: Luteolysis and the Corpus Luteum of Pregnancy - p. 267 26. IV: Novel Experimental Models - p. 292 27. Chapter 18: Transgenic Mouse Models in the Study of Ovarian Function - p. 292 28. Chapter 19: Genome-Wide Association Studies of Ovarian Function Disorders - p. 310 29. Chapter 20: Mitochondria Research in Human Reproduction - p. 325 30. Chapter 21: The Role of Mitochondria in Reproductive Function and Assisted Reproduction - p. 335 31. V: Human Ovarian Pathophysiology: Select Aspects - p. 342 32. Chapter 22: Ovarian Hyperstimulation Syndrome - p. 342 33. Chapter 23: The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols - p. 362 34. Chapter 24: The Ovarian Factor in Assisted Reproductive Technology - p. 377 35. Chapter 25: The Role of Antimullerian Hormone in Assisted Reproduction - p. 401 36. Chapter 26: Polycystic Ovary Syndrome - p. 414 37. Chapter 27: Genetic and Environmental Factors in the Etiology of Polycystic Ovary Syndrome - p. 435 38. Chapter 28: Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders - p. 459 39. Chapter 29: Environmental Contaminants and Ovarian Toxicity - p. 484 40. Chapter 30: Autologous Transplantation of Human Ovarian Tissue - p. 491 41. Chapter 31: Oncofertility: Preservation of Ovarian Function After a Cancer Diagnosis - p. 500 42. VI: Human Ovarian Cancer - p. 508 43. Chapter 32: Ovarian Cancers: Their Varied Origins and Pathologically Implicated Microenvironment - p. 508 44. Chapter 33: Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer - p. 528 45. Chapter 34: Novel Therapeutic Approaches and Targets for Ovarian Cancer - p. 545 46. Chapter 35: Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer - p. 574 47. Index - p. 595
The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This updated edition synthesizes new information at the molecular, cellular and organismal levels, while also presenting modern ovarian physiology in a more understandable and comparative context. The book looks at ovarian function from a detailed molecular and cellular level that examines all phases of the ovarian lifecycle that places special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. iv 6. I: The Ovarian Follicular Apparatus: Operational Characteristics - p. iv 7. Chapter 1: Follicle Selection in Mammalian Ovaries - p. iv 8. Chapter 2: Regulation of Follicle Formation and Development by Ovarian Signaling Pathways - p. 21 9. Chapter 3: Human Folliculogenesis Revisited: The Menstrual Cycle Visualized by Ultrasonography - p. 49 10. Chapter 4: Development of the Mammalian Ovary and Follicles - p. 69 11. Chapter 5: Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism - p. 82 12. Chapter 6: Inhibin, Activin, and Follistatin in Ovarian Physiology - p. 94 13. Chapter 7: Cell-Cell Interactions in Ovarian Follicles: Role of TGF-β Superfamily Members - p. 105 14. Chapter 8: Mutations and Polymorphisms, and Their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes - p. 125 15. Chapter 9: Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease - p. 148 16. II: Oocyte Maturation and Ovulation - p. 154 17. Chapter 10: Mammalian Oogenesis: The Fragile Foundation of the Next Generation - p. 154 18. Chapter 11: Regulation of Mammalian Oocyte Maturation - p. 164 19. Chapter 12: Oocyte Meiotic Maturation - p. 180 20. Chapter 13: Gene Expression During Oogenesis and Oocyte Development - p. 203 21. Chapter 14: Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte Release - p. 216 22. III: The Corpus Luteum - p. 234 23. Chapter 15: Molecular Regulation of Progesterone Production in the Corpus Luteum - p. 234 24. Chapter 16: Corpus Luteum Formation - p. 253 25. Chapter 17: Luteolysis and the Corpus Luteum of Pregnancy - p. 267 26. IV: Novel Experimental Models - p. 292 27. Chapter 18: Transgenic Mouse Models in the Study of Ovarian Function - p. 292 28. Chapter 19: Genome-Wide Association Studies of Ovarian Function Disorders - p. 310 29. Chapter 20: Mitochondria Research in Human Reproduction - p. 325 30. Chapter 21: The Role of Mitochondria in Reproductive Function and Assisted Reproduction - p. 335 31. V: Human Ovarian Pathophysiology: Select Aspects - p. 342 32. Chapter 22: Ovarian Hyperstimulation Syndrome - p. 342 33. Chapter 23: The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols - p. 362 34. Chapter 24: The Ovarian Factor in Assisted Reproductive Technology - p. 377 35. Chapter 25: The Role of Antimullerian Hormone in Assisted Reproduction - p. 401 36. Chapter 26: Polycystic Ovary Syndrome - p. 414 37. Chapter 27: Genetic and Environmental Factors in the Etiology of Polycystic Ovary Syndrome - p. 435 38. Chapter 28: Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders - p. 459 39. Chapter 29: Environmental Contaminants and Ovarian Toxicity - p. 484 40. Chapter 30: Autologous Transplantation of Human Ovarian Tissue - p. 491 41. Chapter 31: Oncofertility: Preservation of Ovarian Function After a Cancer Diagnosis - p. 500 42. VI: Human Ovarian Cancer - p. 508 43. Chapter 32: Ovarian Cancers: Their Varied Origins and Pathologically Implicated Microenvironment - p. 508 44. Chapter 33: Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer - p. 528 45. Chapter 34: Novel Therapeutic Approaches and Targets for Ovarian Cancer - p. 545 46. Chapter 35: Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer - p. 574 47. Index - p. 595
