Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing.
Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Chapter 1. Epigenetic Regulation of Open Chromatin in Pluripotent Stem Cells - p. 1 7. Chapter 2. RNA Epigenetics (Epitranscriptomics) - p. 19 8. Chapter 3. The Nucleosome Remodeling and Deacetylase Complex in Development and Disease - p. 37 9. Chapter 4. Epigenetics and Muscle Dysfunction in Chronic Obstructive Pulmonary Disease - p. 73 10. Chapter 5. Clinical Epigenetics of Lung Cancer - p. 97 11. Chapter 6. Epigenetics in Cardiovascular Disease - p. 135 12. Chapter 7. Epigenetics and Arterial Hypertension: Evidences and Perspectives - p. 159 13. Chapter 8. Epigenetics in Chronic Pain - p. 185 14. Chapter 9. Epigenomics of Alzheimer’s Disease - p. 227 15. Chapter 10. Prospective Epigenetic Paradigms and Models for Cellular Senescence and Epithelial–Mesenchymal Transition in Organismal Development and Aging - p. 279 16. Index - p. 299
Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing.
Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Chapter 1. Epigenetic Regulation of Open Chromatin in Pluripotent Stem Cells - p. 1 7. Chapter 2. RNA Epigenetics (Epitranscriptomics) - p. 19 8. Chapter 3. The Nucleosome Remodeling and Deacetylase Complex in Development and Disease - p. 37 9. Chapter 4. Epigenetics and Muscle Dysfunction in Chronic Obstructive Pulmonary Disease - p. 73 10. Chapter 5. Clinical Epigenetics of Lung Cancer - p. 97 11. Chapter 6. Epigenetics in Cardiovascular Disease - p. 135 12. Chapter 7. Epigenetics and Arterial Hypertension: Evidences and Perspectives - p. 159 13. Chapter 8. Epigenetics in Chronic Pain - p. 185 14. Chapter 9. Epigenomics of Alzheimer’s Disease - p. 227 15. Chapter 10. Prospective Epigenetic Paradigms and Models for Cellular Senescence and Epithelial–Mesenchymal Transition in Organismal Development and Aging - p. 279 16. Index - p. 299
