The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups.
The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow’s practice.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. Foreword - p. xxi 9. Preface - p. xxiii 10. Section 1: Currently accepted glaucoma practice - p. S1 11. Chapter 1. Glaucoma pathology - p. 3 12. Chapter 2. Epidemiology of glaucoma - p. 17 13. Chapter 3. Diagnosis and investigations in glaucoma - p. 35 14. Chapter 4. Follow-up - p. 41 15. Chapter 5. Glaucoma management - p. 45 16. Chapter 6. Section summary: into the unknown—identifying the needs - p. 49 17. Section 2: Pathophysiology and investigation methods - p. S51 18. Chapter 7. Considerations for an effective screening program for glaucoma - p. 53 19. Chapter 8. Vascular health and glaucoma - p. 63 20. Chapter 9. The role of circadian and extrinsic intraocular pressure fluctuations - p. 81 21. Chapter 10. Pseudoexfoliative glaucoma: epidemiology, pathophysiology, and clinical implications - p. 89 22. Chapter 11. Angle-closure glaucoma: epidemiology, pathophysiology, and clinical impact - p. 105 23. Chapter 12. The role of optical coherence tomography angiography in glaucoma - p. 115 24. Chapter 13. Structural testing modalities: RNFL, GCIPL, BMO-MRW, or vessel density? - p. 127 25. Chapter 14. Visual field testing: how frequent is frequent enough, and other developments - p. 135 26. Chapter 15. Novelties in functional testing: the role of contrast sensitivity, electrophysiology, and color vision - p. 147 27. Chapter 16. Managing uncertainty in glaucoma - p. 165 28. Section 3: Medical and laser therapies - p. S169 29. Chapter 17. Psychological barriers and innovations in glaucoma adherence - p. 171 30. Chapter 18. Topical medications and the ocular surface - p. 179 31. Chapter 19. Novel approaches to reducing intraocular pressure—today and tomorrow - p. 187 32. Chapter 20. Novel ocular drug delivery systems in glaucoma - p. 203 33. Chapter 21. Selective laser trabeculoplasty: physiology and effects of SLT - p. 209 34. Chapter 22. Aqueous humor, glaucoma, and corneal health - p. 217 35. Chapter 23. Meditation for glaucoma management: cellular mechanisms and clinical impact - p. 231 36. Chapter 24. Section summary: recommendations in treatment-naïve open-angle glaucoma, treatment escalation protocols, and patient-specific considerations - p. 247 37. Section 4: Surgical options - p. S251 38. Chapter 25. Anatomical, mechanical, and physiological effect of cataract surgery in open-angle and narrow-angle glaucoma - p. 253 39. Chapter 26. 21st-century functional outflow system anatomy for surgeons - p. 261 40. Chapter 27. The role of ocular inflammation, fluid dynamics, and bleb morphology in surgical outcomes - p. 287 41. Chapter 28. Aqueous humor outflow imaging and minimally invasive glaucoma surgeries - p. 305 42. Chapter 29. Microinvasive glaucoma surgery device design considerations - p. 317 43. Chapter 30. Adjustable drainage devices - p. 329 44. Chapter 31. Continuous intraocular pressure measurement - p. 335 45. Chapter 32. Cyclophotocoagulation: a look at the history, the accepted norm, and the future possibilities - p. 349 46. Chapter 33. Section summary: determination of the ideal patient–surgeon–procedure match - p. 367 47. Section 5: New technologies - p. S371 48. Chapter 34. Artificial intelligence and big data: technical considerations and clinical applications - p. 373 49. Chapter 35. Detection of apoptosing retinal cells in glaucoma - p. 387 50. Chapter 36. Neuroprotection and neuroenhancement - p. 397 51. Chapter 37. Clinical trials in neuroprotection: special considerations - p. 407 52. Chapter 38. Neuro-regeneration and stem-cell therapies - p. 415 53. Chapter 39. Genetic testing and gene therapy in glaucoma - p. 429 54. Chapter 40. Conclusion: glaucoma, moving forward - p. 437 55. Index - p. 443
The Science of Glaucoma Management: From Translational Research to Next-Generation Clinical Practice bridges the gap between laboratory research and clinicians by bringing the latest promising research directly from researchers to clinicians long before they translate into clinical advances, and often before they are presented at conferences. Organized as a series of clinically relevant topics written by world-leading experts, this book summarizes the current state of laboratory and translational research and draws on the potential implications for day-to-day clinical practice. It offers new insights and mind-opening statements through contributions from some of the most respected glaucoma research groups.
The book allows glaucoma specialists to explore novel ways to refine and rethink their practice based on the latest discoveries in basic sciences and breakthrough technologies, and to gain a better understanding on how their specialty is evolving and how research may shape tomorrow’s practice.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xvii 8. Foreword - p. xxi 9. Preface - p. xxiii 10. Section 1: Currently accepted glaucoma practice - p. S1 11. Chapter 1. Glaucoma pathology - p. 3 12. Chapter 2. Epidemiology of glaucoma - p. 17 13. Chapter 3. Diagnosis and investigations in glaucoma - p. 35 14. Chapter 4. Follow-up - p. 41 15. Chapter 5. Glaucoma management - p. 45 16. Chapter 6. Section summary: into the unknown—identifying the needs - p. 49 17. Section 2: Pathophysiology and investigation methods - p. S51 18. Chapter 7. Considerations for an effective screening program for glaucoma - p. 53 19. Chapter 8. Vascular health and glaucoma - p. 63 20. Chapter 9. The role of circadian and extrinsic intraocular pressure fluctuations - p. 81 21. Chapter 10. Pseudoexfoliative glaucoma: epidemiology, pathophysiology, and clinical implications - p. 89 22. Chapter 11. Angle-closure glaucoma: epidemiology, pathophysiology, and clinical impact - p. 105 23. Chapter 12. The role of optical coherence tomography angiography in glaucoma - p. 115 24. Chapter 13. Structural testing modalities: RNFL, GCIPL, BMO-MRW, or vessel density? - p. 127 25. Chapter 14. Visual field testing: how frequent is frequent enough, and other developments - p. 135 26. Chapter 15. Novelties in functional testing: the role of contrast sensitivity, electrophysiology, and color vision - p. 147 27. Chapter 16. Managing uncertainty in glaucoma - p. 165 28. Section 3: Medical and laser therapies - p. S169 29. Chapter 17. Psychological barriers and innovations in glaucoma adherence - p. 171 30. Chapter 18. Topical medications and the ocular surface - p. 179 31. Chapter 19. Novel approaches to reducing intraocular pressure—today and tomorrow - p. 187 32. Chapter 20. Novel ocular drug delivery systems in glaucoma - p. 203 33. Chapter 21. Selective laser trabeculoplasty: physiology and effects of SLT - p. 209 34. Chapter 22. Aqueous humor, glaucoma, and corneal health - p. 217 35. Chapter 23. Meditation for glaucoma management: cellular mechanisms and clinical impact - p. 231 36. Chapter 24. Section summary: recommendations in treatment-naïve open-angle glaucoma, treatment escalation protocols, and patient-specific considerations - p. 247 37. Section 4: Surgical options - p. S251 38. Chapter 25. Anatomical, mechanical, and physiological effect of cataract surgery in open-angle and narrow-angle glaucoma - p. 253 39. Chapter 26. 21st-century functional outflow system anatomy for surgeons - p. 261 40. Chapter 27. The role of ocular inflammation, fluid dynamics, and bleb morphology in surgical outcomes - p. 287 41. Chapter 28. Aqueous humor outflow imaging and minimally invasive glaucoma surgeries - p. 305 42. Chapter 29. Microinvasive glaucoma surgery device design considerations - p. 317 43. Chapter 30. Adjustable drainage devices - p. 329 44. Chapter 31. Continuous intraocular pressure measurement - p. 335 45. Chapter 32. Cyclophotocoagulation: a look at the history, the accepted norm, and the future possibilities - p. 349 46. Chapter 33. Section summary: determination of the ideal patient–surgeon–procedure match - p. 367 47. Section 5: New technologies - p. S371 48. Chapter 34. Artificial intelligence and big data: technical considerations and clinical applications - p. 373 49. Chapter 35. Detection of apoptosing retinal cells in glaucoma - p. 387 50. Chapter 36. Neuroprotection and neuroenhancement - p. 397 51. Chapter 37. Clinical trials in neuroprotection: special considerations - p. 407 52. Chapter 38. Neuro-regeneration and stem-cell therapies - p. 415 53. Chapter 39. Genetic testing and gene therapy in glaucoma - p. 429 54. Chapter 40. Conclusion: glaucoma, moving forward - p. 437 55. Index - p. 443
