The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney.
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.
1. The Vasculome - p. i 2. Cover - p. i 3. Companion Website - p. ii 4. Title Page - p. iii 5. Copyright Page - p. iv 6. Table of Contents - p. iv 7. Contributors - p. xi 8. Preamble - p. xvii 9. Acknowledgment - p. xxxi 10. List of Abbreviations - p. xxxiii 11. Chapter 1 Development of, and environmental impact on, endothelial cell diversity - p. 5 12. Chapter 2 Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies - p. 17 13. Chapter 3 The remarkable diversity of vascular smooth muscle in development and disease - p. 31 14. Chapter 4 Smooth muscle diversity in the vascular system - p. 45 15. Chapter 5 Resident vascular immune cells in health and atherosclerotic disease - p. 57 16. Chapter 6 Perivascular adipose tissue - p. 71 17. Chapter 7 Major vascular ECM components, differential distribution supporting structure, and functions of the vasculome - p. 77 18. Chapter 8 Out to the tissues - p. 89 19. Chapter 9 Capillary diversity - p. 99 20. Chapter 10 The neurovascular unit and blood–CNS barriers in health and disease - p. 111 21. Chapter 11 Lymphatic biology and medicine - p. 127 22. Chapter 12 The flow-dependent endotheliome - p. 143 23. Chapter 13 Intravital photoacoustic microscopy of microvascular function and oxygen metabolism - p. 151 24. Chapter 14 Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases - p. 163 25. Chapter 15 Simulation of blood flow and oxygen transport in vascular networks - p. 173 26. Chapter 16 Clinical investigations of vascular function - p. 181 27. Chapter 17 Angiodiversity—A tale retold by comparative transcriptomics - p. 199 28. Chapter 18 Using pattern recognition and discriminant analysis of functional perfusion data to create “angioprints” for normal and perturbed angiogenic microvascular networks - p. 219 29. Chapter 19 Artificial intelligence for the vasculome - p. 229 30. Chapter 20 Vascular development and organogenesis - p. 241 31. Chapter 21 Normal vascular identity (arteries, veins, and lymphatics) and malformations - p. 251 32. Chapter 22 Sprouting angiogenesis in vascular and lymphatic development - p. 265 33. Chapter 23 Enablers and drivers of vascular remodeling - p. 277 34. Chapter 24 Extracellular matrix dynamics and contribution to vascular pathologies - p. 287 35. Chapter 25 Lymphatic vascular anomalies and dysfunction - p. 301 36. Chapter 26 Endothelial dysfunction: basis for many local and systemic conditions - p. 313 37. Chapter 27 The vascular phenotype in hypertension - p. 327 38. Chapter 28 Functional roles of lymphatics in health and disease - p. 343 39. Chapter 29 Extracellular matrix genetics of thoracic and abdominal aortic diseases - p. 351 40. Chapter 30 Peripheral arterial disease (pathophysiology, presentation, prevention/management) - p. 361 41. Chapter 31 Venous diseases including thromboembolic phenomena - p. 377 42. Chapter 32 Targeting vascular zip codes - p. 393 43. Chapter 33 Angiosome concept for vascular interventions - p. 403 44. Chapter 34 RNA therapies for cardiovascular disease - p. 413 45. Chapter 35 The brain vasculome - p. 427 46. Chapter 36 Vasculome - p. 441 47. Chapter 37 The Vasculome provides a body-wide cellular positioning system and functional barometer. The “Vasculature as Common Coordinate Frame (VCCF)” concept - p. 453 48. Index - p. 461 49. Index - Continued - p. 472
The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney.
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.
1. The Vasculome - p. i 2. Cover - p. i 3. Companion Website - p. ii 4. Title Page - p. iii 5. Copyright Page - p. iv 6. Table of Contents - p. iv 7. Contributors - p. xi 8. Preamble - p. xvii 9. Acknowledgment - p. xxxi 10. List of Abbreviations - p. xxxiii 11. Chapter 1 Development of, and environmental impact on, endothelial cell diversity - p. 5 12. Chapter 2 Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies - p. 17 13. Chapter 3 The remarkable diversity of vascular smooth muscle in development and disease - p. 31 14. Chapter 4 Smooth muscle diversity in the vascular system - p. 45 15. Chapter 5 Resident vascular immune cells in health and atherosclerotic disease - p. 57 16. Chapter 6 Perivascular adipose tissue - p. 71 17. Chapter 7 Major vascular ECM components, differential distribution supporting structure, and functions of the vasculome - p. 77 18. Chapter 8 Out to the tissues - p. 89 19. Chapter 9 Capillary diversity - p. 99 20. Chapter 10 The neurovascular unit and blood–CNS barriers in health and disease - p. 111 21. Chapter 11 Lymphatic biology and medicine - p. 127 22. Chapter 12 The flow-dependent endotheliome - p. 143 23. Chapter 13 Intravital photoacoustic microscopy of microvascular function and oxygen metabolism - p. 151 24. Chapter 14 Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases - p. 163 25. Chapter 15 Simulation of blood flow and oxygen transport in vascular networks - p. 173 26. Chapter 16 Clinical investigations of vascular function - p. 181 27. Chapter 17 Angiodiversity—A tale retold by comparative transcriptomics - p. 199 28. Chapter 18 Using pattern recognition and discriminant analysis of functional perfusion data to create “angioprints” for normal and perturbed angiogenic microvascular networks - p. 219 29. Chapter 19 Artificial intelligence for the vasculome - p. 229 30. Chapter 20 Vascular development and organogenesis - p. 241 31. Chapter 21 Normal vascular identity (arteries, veins, and lymphatics) and malformations - p. 251 32. Chapter 22 Sprouting angiogenesis in vascular and lymphatic development - p. 265 33. Chapter 23 Enablers and drivers of vascular remodeling - p. 277 34. Chapter 24 Extracellular matrix dynamics and contribution to vascular pathologies - p. 287 35. Chapter 25 Lymphatic vascular anomalies and dysfunction - p. 301 36. Chapter 26 Endothelial dysfunction: basis for many local and systemic conditions - p. 313 37. Chapter 27 The vascular phenotype in hypertension - p. 327 38. Chapter 28 Functional roles of lymphatics in health and disease - p. 343 39. Chapter 29 Extracellular matrix genetics of thoracic and abdominal aortic diseases - p. 351 40. Chapter 30 Peripheral arterial disease (pathophysiology, presentation, prevention/management) - p. 361 41. Chapter 31 Venous diseases including thromboembolic phenomena - p. 377 42. Chapter 32 Targeting vascular zip codes - p. 393 43. Chapter 33 Angiosome concept for vascular interventions - p. 403 44. Chapter 34 RNA therapies for cardiovascular disease - p. 413 45. Chapter 35 The brain vasculome - p. 427 46. Chapter 36 Vasculome - p. 441 47. Chapter 37 The Vasculome provides a body-wide cellular positioning system and functional barometer. The “Vasculature as Common Coordinate Frame (VCCF)” concept - p. 453 48. Index - p. 461 49. Index - Continued - p. 472
