Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xv 7. About the editor - p. xxi 8. Preface - p. xxiii 9. Endorsements - p. xxv 10. Part 1: Modern tools and concepts in toxicology testing - p. xxvii 11. Chapter 1. Mixture toxicity evaluation in modern toxicology - p. 3 12. Chapter 2. Alternative methods to animal experimentation and their role in modern toxicology - p. 13 13. Chapter 3. The exposome—a new paradigm for non-animal toxicology and integrated risk assessment - p. 23 14. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment - p. 31 15. Chapter 5. Safety science in the 21st century—a scientific revolution in its making - p. 51 16. Chapter 6. Chemobrain - p. 61 17. Part 2: Methods and toxicity models in toxicology - p. 69 18. Chapter 7. “Predictive in silico toxicology.” An update on modern approaches and a critical analysis of its strong and weak points - p. 75 19. Chapter 8. Analytical strategies to study the gut microbiome in toxicology - p. 85 20. Chapter 9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides - p. 95 21. Chapter 10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress - p. 105 22. Chapter 11. The potential of complex in vitro models in pharmaceutical toxicology - p. 115 23. Part 3: New insights in risk assessment - p. 126 24. Chapter 12. Health-based exposure limits and toxicology in the pharmaceutical industry - p. 131 25. Chapter 13. The hormetic dose response: implications for risk assessment - p. 139 26. Chapter 14. Endocrine disruption and human health risk assessment in the light of real-life risk simulation - p. 147 27. Chapter 15. Toxicity data as the basis for acute and short-term emergency exposure guidance - p. 163 28. Chapter 16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs - p. 175 29. Part 4: Clinical biomarkers updates - p. 186 30. Chapter 17. Updates on current biomarkers in toxicology - p. 191 31. Chapter 18. The role of extracellular matrix in allergic contact dermatitis pathogenesis - p. 205 32. Chapter 19. Review of current neurotoxicology biomarkers - p. 215 33. Chapter 20. Modern aspects of immunotoxicology - p. 233 34. Chapter 21. Toxicology of neurodegenerative diseases - p. 247 35. Chapter 22. Toxicogenetics—Pharmacogenetics: Genetic variability profiling for xenobiotic response heterogeneity - p. 259 36. Chapter 23. Current and emerging concepts of cardiotoxicity - p. 269 37. Chapter 24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology - p. 275 38. Chapter 25. Metabolomics methodology and workflow: challenges and future prospects - p. 285 39. Chapter 26. Telomere length: associations with nutrients and xenobiotics - p. 295 40. Part 5: Epidemiology and public health toxicology issues - p. 303 41. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment - p. 309 42. Chapter 28. Modern approaches for the assessment of human exposure to dietary mycotoxins - p. 323 43. Chapter 29. Tobacco toxicity and regulatory science - p. 337 44. Chapter 30. Dethroning the crown. From the kinetics and dynamics of COVID–19 diagnosis to promising treatments - p. 349 45. Chapter 31. Toxicology issues related to the COVID–19 outbreak - p. 359 46. Chapter 32. Risk assessment for heat stress during work and leisure - p. 373 47. Part 6: Pharmaceuticals and nutraceuticals toxicology updates - p. 382 48. Chapter 33. Polyphenols: the hallmark of endothelial dysfunction combatants - p. 389 49. Chapter 34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability - p. 403 50. Chapter 35. Hydrogen sulfide: a shifting paradigm - p. 415 51. Chapter 36. Redox biomarkers in toxicology and nutrition: the social link - p. 427 52. Chapter 37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide - p. 435 53. Part 7: Toxicology of biomaterials and nanomaterials - p. 444 54. Chapter 38. Epigenetic mechanisms in nanomaterial toxicity - p. 451 55. Chapter 39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials - p. 459 56. Chapter 40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae - p. 479 57. Chapter 41. Aquatic nanotoxicology: reference species and omics technologies - p. 495 58. Part 8: Special topics in toxicology - p. 508 59. Chapter 42. Toxicity of arsenicals in diseases: friend or foe? - p. 517 60. Chapter 43. Toxicity of psychedelic drugs - p. 545 61. Chapter 44. Immunotoxicity of pesticides: current knowledge and perspectives - p. 557 62. Chapter 45. Glyphosate-based herbicides: evidence of immune-endocrine-microbiome alteration - p. 569 63. Chapter 46. Ciguatera toxins: toxicity and food safety - p. 579 64. Chapter 47. Cannabinoids and psychosis: current challenges of mechanistic toxicology - p. 601 65. Chapter 48. Electronic cigarettes as a harm reduction concept for public health - p. 617 66. Index - p. 645
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xv 7. About the editor - p. xxi 8. Preface - p. xxiii 9. Endorsements - p. xxv 10. Part 1: Modern tools and concepts in toxicology testing - p. xxvii 11. Chapter 1. Mixture toxicity evaluation in modern toxicology - p. 3 12. Chapter 2. Alternative methods to animal experimentation and their role in modern toxicology - p. 13 13. Chapter 3. The exposome—a new paradigm for non-animal toxicology and integrated risk assessment - p. 23 14. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment - p. 31 15. Chapter 5. Safety science in the 21st century—a scientific revolution in its making - p. 51 16. Chapter 6. Chemobrain - p. 61 17. Part 2: Methods and toxicity models in toxicology - p. 69 18. Chapter 7. “Predictive in silico toxicology.” An update on modern approaches and a critical analysis of its strong and weak points - p. 75 19. Chapter 8. Analytical strategies to study the gut microbiome in toxicology - p. 85 20. Chapter 9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides - p. 95 21. Chapter 10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress - p. 105 22. Chapter 11. The potential of complex in vitro models in pharmaceutical toxicology - p. 115 23. Part 3: New insights in risk assessment - p. 126 24. Chapter 12. Health-based exposure limits and toxicology in the pharmaceutical industry - p. 131 25. Chapter 13. The hormetic dose response: implications for risk assessment - p. 139 26. Chapter 14. Endocrine disruption and human health risk assessment in the light of real-life risk simulation - p. 147 27. Chapter 15. Toxicity data as the basis for acute and short-term emergency exposure guidance - p. 163 28. Chapter 16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs - p. 175 29. Part 4: Clinical biomarkers updates - p. 186 30. Chapter 17. Updates on current biomarkers in toxicology - p. 191 31. Chapter 18. The role of extracellular matrix in allergic contact dermatitis pathogenesis - p. 205 32. Chapter 19. Review of current neurotoxicology biomarkers - p. 215 33. Chapter 20. Modern aspects of immunotoxicology - p. 233 34. Chapter 21. Toxicology of neurodegenerative diseases - p. 247 35. Chapter 22. Toxicogenetics—Pharmacogenetics: Genetic variability profiling for xenobiotic response heterogeneity - p. 259 36. Chapter 23. Current and emerging concepts of cardiotoxicity - p. 269 37. Chapter 24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology - p. 275 38. Chapter 25. Metabolomics methodology and workflow: challenges and future prospects - p. 285 39. Chapter 26. Telomere length: associations with nutrients and xenobiotics - p. 295 40. Part 5: Epidemiology and public health toxicology issues - p. 303 41. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment - p. 309 42. Chapter 28. Modern approaches for the assessment of human exposure to dietary mycotoxins - p. 323 43. Chapter 29. Tobacco toxicity and regulatory science - p. 337 44. Chapter 30. Dethroning the crown. From the kinetics and dynamics of COVID–19 diagnosis to promising treatments - p. 349 45. Chapter 31. Toxicology issues related to the COVID–19 outbreak - p. 359 46. Chapter 32. Risk assessment for heat stress during work and leisure - p. 373 47. Part 6: Pharmaceuticals and nutraceuticals toxicology updates - p. 382 48. Chapter 33. Polyphenols: the hallmark of endothelial dysfunction combatants - p. 389 49. Chapter 34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability - p. 403 50. Chapter 35. Hydrogen sulfide: a shifting paradigm - p. 415 51. Chapter 36. Redox biomarkers in toxicology and nutrition: the social link - p. 427 52. Chapter 37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide - p. 435 53. Part 7: Toxicology of biomaterials and nanomaterials - p. 444 54. Chapter 38. Epigenetic mechanisms in nanomaterial toxicity - p. 451 55. Chapter 39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials - p. 459 56. Chapter 40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae - p. 479 57. Chapter 41. Aquatic nanotoxicology: reference species and omics technologies - p. 495 58. Part 8: Special topics in toxicology - p. 508 59. Chapter 42. Toxicity of arsenicals in diseases: friend or foe? - p. 517 60. Chapter 43. Toxicity of psychedelic drugs - p. 545 61. Chapter 44. Immunotoxicity of pesticides: current knowledge and perspectives - p. 557 62. Chapter 45. Glyphosate-based herbicides: evidence of immune-endocrine-microbiome alteration - p. 569 63. Chapter 46. Ciguatera toxins: toxicity and food safety - p. 579 64. Chapter 47. Cannabinoids and psychosis: current challenges of mechanistic toxicology - p. 601 65. Chapter 48. Electronic cigarettes as a harm reduction concept for public health - p. 617 66. Index - p. 645
