Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xvii 6. Preface - p. page_xxv 7. Part I: Toxicology and oxidative stress: General aspects, agricultural and industrial chemicals - p. page_xxv 8. Chapter 1: Agrochemicals inhibiting mitochondrial respiration: Their effects on oxidative stress - p. page_3 9. Chapter 2: Nanoparticle toxicity and reactive species: An overview - p. page_11 10. Chapter 3: Oxidative stress status and industrial discharges - p. page_23 11. Chapter 4: Terpene toxicity and oxidative stress - p. page_33 12. Chapter 5: Antioxidant status in pesticides-exposed agricultural workers - p. page_43 13. Chapter 6: Antioxidant genes, the insecticide diazinon, and toxicity - p. page_53 14. Chapter 7: Dimethoate organophosphate insecticide toxicity and the role of oxidative stress - p. page_59 15. Chapter 8: Oxidative stress in paraquat-induced damage to nervous tissues - p. page_69 16. Chapter 9: Glyphosate-based herbicides and oxidative stress - p. page_79 17. Chapter 10: NRF2 and paraquat-induced fatal redox stress - p. page_91 18. Chapter 11: Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III), or nickel(II) - p. page_99 19. Chapter 12: Oxidative stress toxicity effect of potential metal nanoparticles on human cells - p. page_107 20. Chapter 13: Oxidative stress and copper smelter workers - p. page_119 21. Chapter 14: Aluminum toxicity and oxidative stress - p. page_127 22. Chapter 15: Methylmercury, oxidative stress, and neurodegeneration - p. page_137 23. Chapter 16: Arsenic-induced oxidative stress in reproductive systems - p. page_145 24. Chapter 17: The role of oxidative stress in fluoride toxicity - p. page_157 25. Chapter 18: Environmentally relevant level of aflatoxin B1 and the role of (non)oxidative immuno-/neurodysregulation and toxicity - p. page_165 26. Chapter 19: A review on the oxidative effects of the fusariotoxins: Fumonisin B1 and fusaric acid - p. page_181 27. Chapter 20: Mycotoxin exposure, oxidative stress, and lipid peroxidation - p. page_191 28. Chapter 21: Toxicological effects of commonly used herbs and spices - p. page_201 29. Chapter 22: Oxidative stress, Chinese herbals and toxicity: A focused review with examples - p. page_215 30. Chapter 23: Alcohol toxicity: The role of oxidative stress - p. page_225 31. Chapter 24: Radiation and oxidative stress - p. page_233 32. Chapter 25: The impact of dimethyl sulfoxide on oxidative stress and cytotoxicity in various experimental models - p. page_243 33. Chapter 26: Statins, toxicity, and their adverse effects via oxidative imbalance - p. page_263 34. Chapter 27: The toxicological impact of some agents on glutathione S-transferase and cholinesterase enzymes - p. page_281 35. Chapter 28: Oxidative stress due to 5-fluorouracil and dietary antioxidants - p. page_291 36. Chapter 29: AZT oxidative damage in the liver - p. page_297 37. Part II: Antioxidants and toxicology: General aspects, agricultural and industrial chemicals - p. page_304 38. Chapter 30: Effects of antioxidant nutrients on ionizing radiation-induced oxidative stress - p. page_307 39. Chapter 31: Linking metabolic profiling, resveratrol, the gut microbiota, and antioxidant potential - p. page_317 40. Chapter 32: Antioxidant and juçara fruits (Euterpe edulis Martius): Potential applications in toxicology - p. page_329 41. Chapter 33: White Butterfly (Clerodendrum volubile) leaves and antioxidant potential in toxicity - p. page_337 42. Chapter 34: Vernonia amygdalina leaf and antioxidant potential - p. page_347 43. Chapter 35: The antioxidant profile of two species belonging to the genus Leonurus. Potential applications in toxicity - p. page_355 44. Chapter 36: Free radicals and coffee polyphenols: Potential applications in toxicity - p. page_363 45. Chapter 37: Amino acids ameliorate heavy metals-induced oxidative stress in male/female reproductive tissue - p. page_371 46. Chapter 38: Betaine, heavy metal protection, oxidative stress, and the liver - p. page_387 47. Chapter 39: An overview on the potential mechanisms of action of N-acetyl-l-cysteine in hexavalent chromium-induced toxicity - p. page_397 48. Chapter 40: Soft electrophile inhibition of selenoenzymes in disease pathologies - p. page_409 49. Chapter 41: Selenium protection against cadmium and lead-induced oxidative stress - p. page_419 50. Chapter 42: Protective effects of vitamin C against fluoride toxicity - p. page_435 51. Chapter 43: Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity - p. page_447 52. Chapter 44: Mycotoxin deoxynivalenol and oxidative stress: Role of silymarin and inulin protection - p. page_457 53. Chapter 45: Curcumin, antioxidant activity, and paracetamol toxicity - p. page_469 54. Chapter 46: Role of semisynthetic flavonoids on cytotoxic chemotherapy—Dual benefit to cancer patients? - p. page_479 55. Chapter 47: Vernonia amygdalina (Del) as an antioxidant, aspirin toxicity, and oxidative stress - p. page_491 56. Chapter 48: Resveratrol and nicotine toxicity - p. page_505 57. Chapter 49: The antioxidant effect of Peruvian maca (Lepidium meyenii) - p. page_519 58. Chapter 50: Aegle marmelos extract (L.) against CCL4 toxicity - p. page_527 59. Chapter 51: Horse mushroom (Agaricus arvensis Schaeff.) prevents oxidative stress in carbon tetrachloride toxicity - p. page_541 60. Chapter 52: Recommended resources on toxicology: oxidative stress and dietary antioxidants - p. page_551 61. Index - p. page_557
Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xvii 6. Preface - p. page_xxv 7. Part I: Toxicology and oxidative stress: General aspects, agricultural and industrial chemicals - p. page_xxv 8. Chapter 1: Agrochemicals inhibiting mitochondrial respiration: Their effects on oxidative stress - p. page_3 9. Chapter 2: Nanoparticle toxicity and reactive species: An overview - p. page_11 10. Chapter 3: Oxidative stress status and industrial discharges - p. page_23 11. Chapter 4: Terpene toxicity and oxidative stress - p. page_33 12. Chapter 5: Antioxidant status in pesticides-exposed agricultural workers - p. page_43 13. Chapter 6: Antioxidant genes, the insecticide diazinon, and toxicity - p. page_53 14. Chapter 7: Dimethoate organophosphate insecticide toxicity and the role of oxidative stress - p. page_59 15. Chapter 8: Oxidative stress in paraquat-induced damage to nervous tissues - p. page_69 16. Chapter 9: Glyphosate-based herbicides and oxidative stress - p. page_79 17. Chapter 10: NRF2 and paraquat-induced fatal redox stress - p. page_91 18. Chapter 11: Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III), or nickel(II) - p. page_99 19. Chapter 12: Oxidative stress toxicity effect of potential metal nanoparticles on human cells - p. page_107 20. Chapter 13: Oxidative stress and copper smelter workers - p. page_119 21. Chapter 14: Aluminum toxicity and oxidative stress - p. page_127 22. Chapter 15: Methylmercury, oxidative stress, and neurodegeneration - p. page_137 23. Chapter 16: Arsenic-induced oxidative stress in reproductive systems - p. page_145 24. Chapter 17: The role of oxidative stress in fluoride toxicity - p. page_157 25. Chapter 18: Environmentally relevant level of aflatoxin B1 and the role of (non)oxidative immuno-/neurodysregulation and toxicity - p. page_165 26. Chapter 19: A review on the oxidative effects of the fusariotoxins: Fumonisin B1 and fusaric acid - p. page_181 27. Chapter 20: Mycotoxin exposure, oxidative stress, and lipid peroxidation - p. page_191 28. Chapter 21: Toxicological effects of commonly used herbs and spices - p. page_201 29. Chapter 22: Oxidative stress, Chinese herbals and toxicity: A focused review with examples - p. page_215 30. Chapter 23: Alcohol toxicity: The role of oxidative stress - p. page_225 31. Chapter 24: Radiation and oxidative stress - p. page_233 32. Chapter 25: The impact of dimethyl sulfoxide on oxidative stress and cytotoxicity in various experimental models - p. page_243 33. Chapter 26: Statins, toxicity, and their adverse effects via oxidative imbalance - p. page_263 34. Chapter 27: The toxicological impact of some agents on glutathione S-transferase and cholinesterase enzymes - p. page_281 35. Chapter 28: Oxidative stress due to 5-fluorouracil and dietary antioxidants - p. page_291 36. Chapter 29: AZT oxidative damage in the liver - p. page_297 37. Part II: Antioxidants and toxicology: General aspects, agricultural and industrial chemicals - p. page_304 38. Chapter 30: Effects of antioxidant nutrients on ionizing radiation-induced oxidative stress - p. page_307 39. Chapter 31: Linking metabolic profiling, resveratrol, the gut microbiota, and antioxidant potential - p. page_317 40. Chapter 32: Antioxidant and juçara fruits (Euterpe edulis Martius): Potential applications in toxicology - p. page_329 41. Chapter 33: White Butterfly (Clerodendrum volubile) leaves and antioxidant potential in toxicity - p. page_337 42. Chapter 34: Vernonia amygdalina leaf and antioxidant potential - p. page_347 43. Chapter 35: The antioxidant profile of two species belonging to the genus Leonurus. Potential applications in toxicity - p. page_355 44. Chapter 36: Free radicals and coffee polyphenols: Potential applications in toxicity - p. page_363 45. Chapter 37: Amino acids ameliorate heavy metals-induced oxidative stress in male/female reproductive tissue - p. page_371 46. Chapter 38: Betaine, heavy metal protection, oxidative stress, and the liver - p. page_387 47. Chapter 39: An overview on the potential mechanisms of action of N-acetyl-l-cysteine in hexavalent chromium-induced toxicity - p. page_397 48. Chapter 40: Soft electrophile inhibition of selenoenzymes in disease pathologies - p. page_409 49. Chapter 41: Selenium protection against cadmium and lead-induced oxidative stress - p. page_419 50. Chapter 42: Protective effects of vitamin C against fluoride toxicity - p. page_435 51. Chapter 43: Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity - p. page_447 52. Chapter 44: Mycotoxin deoxynivalenol and oxidative stress: Role of silymarin and inulin protection - p. page_457 53. Chapter 45: Curcumin, antioxidant activity, and paracetamol toxicity - p. page_469 54. Chapter 46: Role of semisynthetic flavonoids on cytotoxic chemotherapy—Dual benefit to cancer patients? - p. page_479 55. Chapter 47: Vernonia amygdalina (Del) as an antioxidant, aspirin toxicity, and oxidative stress - p. page_491 56. Chapter 48: Resveratrol and nicotine toxicity - p. page_505 57. Chapter 49: The antioxidant effect of Peruvian maca (Lepidium meyenii) - p. page_519 58. Chapter 50: Aegle marmelos extract (L.) against CCL4 toxicity - p. page_527 59. Chapter 51: Horse mushroom (Agaricus arvensis Schaeff.) prevents oxidative stress in carbon tetrachloride toxicity - p. page_541 60. Chapter 52: Recommended resources on toxicology: oxidative stress and dietary antioxidants - p. page_551 61. Index - p. page_557
