Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.
1. Chapter 1. Introduction on challenges for autoimmune diseases - p. 1 2. Chapter 2. From horror autotoxicus to autoimmunity. An historical note - p. 9 3. Chapter 3. Flow cytometry in the diagnosis of autoimmune-related lymphoproliferative disorder and lymphoma in the head and neck region - p. 17 4. Chapter 4. Autoantigens in atopic dermatitis: The characterization of autoantigens and their diagnostic value - p. 37 5. Chapter 5. Current paradigms of pathogenesis and challenges in vitiligo translational research - p. 49 6. Chapter 6. The role of kynurenine pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin - p. 79 7. Chapter 7. COVID-19 in childhood and phenotypes of pediatric inflammatory multisystem syndrome - p. 91 8. Chapter 8. Autoimmune conditions and epigenetic challenges in periodontitis - p. 108 9. Chapter 9. Neutrophil extracellular traps in autoimmunity, renal diseases, and transplantation - p. 121 10. Chapter 10. Membranous nephropathy: Clinical and immunological aspects - p. 139 11. Chapter 11. Testicular immune tolerance and viral infections - p. 169 12. Chapter 12. Ophthalmological manifestations of systemic autoimmune diseases - p. 183 13. Chapter 13. Challenges for diagnosis and treatment of primary biliary cholangitis - p. 220 14. Chapter 14. Modeling primary biliary cholangitis and primary sclerosing cholangitis as infectious diseases - p. 243 15. Chapter 15. Humoral epitope spreading in autoimmune bullous diseases: An update - p. 287 16. Chapter 16. Dermatologic autoimmunity associated with immune checkpoint inhibitors - p. 312 17. Chapter 17. Insights and strategies to promote immune tolerance in allogeneic hematopoietic stem cell transplantation recipients - p. 329 18. Chapter 18. The potential of cellular transplantation to harness autoimmunity and reverse clinical diabetes - p. 361 19. Index - p. 387
Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.
1. Chapter 1. Introduction on challenges for autoimmune diseases - p. 1 2. Chapter 2. From horror autotoxicus to autoimmunity. An historical note - p. 9 3. Chapter 3. Flow cytometry in the diagnosis of autoimmune-related lymphoproliferative disorder and lymphoma in the head and neck region - p. 17 4. Chapter 4. Autoantigens in atopic dermatitis: The characterization of autoantigens and their diagnostic value - p. 37 5. Chapter 5. Current paradigms of pathogenesis and challenges in vitiligo translational research - p. 49 6. Chapter 6. The role of kynurenine pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin - p. 79 7. Chapter 7. COVID-19 in childhood and phenotypes of pediatric inflammatory multisystem syndrome - p. 91 8. Chapter 8. Autoimmune conditions and epigenetic challenges in periodontitis - p. 108 9. Chapter 9. Neutrophil extracellular traps in autoimmunity, renal diseases, and transplantation - p. 121 10. Chapter 10. Membranous nephropathy: Clinical and immunological aspects - p. 139 11. Chapter 11. Testicular immune tolerance and viral infections - p. 169 12. Chapter 12. Ophthalmological manifestations of systemic autoimmune diseases - p. 183 13. Chapter 13. Challenges for diagnosis and treatment of primary biliary cholangitis - p. 220 14. Chapter 14. Modeling primary biliary cholangitis and primary sclerosing cholangitis as infectious diseases - p. 243 15. Chapter 15. Humoral epitope spreading in autoimmune bullous diseases: An update - p. 287 16. Chapter 16. Dermatologic autoimmunity associated with immune checkpoint inhibitors - p. 312 17. Chapter 17. Insights and strategies to promote immune tolerance in allogeneic hematopoietic stem cell transplantation recipients - p. 329 18. Chapter 18. The potential of cellular transplantation to harness autoimmunity and reverse clinical diabetes - p. 361 19. Index - p. 387
