Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery.
1. Introduction - p. xv 2. Section 1: Glycobiology - p. xix 3. Chapter 1. Carbohydrates and human glycosylation - p. 3 4. Chapter 2. Lectins and their applications in biomedical research - p. 37 5. Chapter 3. Carbohydrate-active enzymes - p. 55 6. Chapter 4. Carbohydrate sulfotransferases in glycosaminoglycan biosynthesis - p. 83 7. Section 2: Glycobiology and health - p. 111 8. Chapter 5. The immune system from a glycobiological point of view - p. 115 9. Chapter 6. Host mucin glycosylation and gut symbiosis - p. 153 10. Chapter 7. Bifidobacteria-accessible carbohydrates in milk - p. 175 11. Chapter 8. Extracellular vesicle glycosylation in transport, signaling, and function - p. 203 12. Section 3: Glycobiology and disease - p. 218 13. Chapter 9. Protein glycosylation in cancer - p. 221 14. Chapter 10. Metabolic diseases: disorders of carbohydrate metabolism and lysosomal storage - p. 255 15. Chapter 11. The glycobiology of microbial infectious disease - p. 285 16. Section 4: Glycotechnologies - p. 322 17. Chapter 12. Elucidation of the structure of carbohydrates and their interactions by nuclear magnetic resonance spectroscopy - p. 325 18. Chapter 13. Development of glycosensors and their applications - p. 341 19. Chapter 14. Systems glycoengineering of therapeutic proteins - p. 363 20. Chapter 15. Understanding glycobiology through multiscale molecular dynamics simulations: From basic principles to case studies - p. 379 21. Section 5: Glycobiology and society - p. 396 22. Chapter 16. Improving impact: Public involvement in glycobiology research - p. 399 23. Chapter 17. Public health and translational glycobiology - p. 421 24. Index - p. 433
Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery.
1. Introduction - p. xv 2. Section 1: Glycobiology - p. xix 3. Chapter 1. Carbohydrates and human glycosylation - p. 3 4. Chapter 2. Lectins and their applications in biomedical research - p. 37 5. Chapter 3. Carbohydrate-active enzymes - p. 55 6. Chapter 4. Carbohydrate sulfotransferases in glycosaminoglycan biosynthesis - p. 83 7. Section 2: Glycobiology and health - p. 111 8. Chapter 5. The immune system from a glycobiological point of view - p. 115 9. Chapter 6. Host mucin glycosylation and gut symbiosis - p. 153 10. Chapter 7. Bifidobacteria-accessible carbohydrates in milk - p. 175 11. Chapter 8. Extracellular vesicle glycosylation in transport, signaling, and function - p. 203 12. Section 3: Glycobiology and disease - p. 218 13. Chapter 9. Protein glycosylation in cancer - p. 221 14. Chapter 10. Metabolic diseases: disorders of carbohydrate metabolism and lysosomal storage - p. 255 15. Chapter 11. The glycobiology of microbial infectious disease - p. 285 16. Section 4: Glycotechnologies - p. 322 17. Chapter 12. Elucidation of the structure of carbohydrates and their interactions by nuclear magnetic resonance spectroscopy - p. 325 18. Chapter 13. Development of glycosensors and their applications - p. 341 19. Chapter 14. Systems glycoengineering of therapeutic proteins - p. 363 20. Chapter 15. Understanding glycobiology through multiscale molecular dynamics simulations: From basic principles to case studies - p. 379 21. Section 5: Glycobiology and society - p. 396 22. Chapter 16. Improving impact: Public involvement in glycobiology research - p. 399 23. Chapter 17. Public health and translational glycobiology - p. 421 24. Index - p. 433
