Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others.
In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.
1. 1. Introduction to systems medicine - p. 1 2. 2. System biology - p. 9 3. 3. Genomic foundation for medical and oral disease translation to clinical assessment - p. 17 4. 4. Proteomics - p. 93 5. 5. Metabolomics in head and neck cancer: A summary of findings - p. 119 6. 6. Microbiomics - p. 137 7. 7. Epigenetics and oral disease - p. 163 8. 8. Systems pharmacology - p. 207 9. 9. Functional “omics” for systems medicine - p. 219 10. 10. Analytic methods for systems medicine - p. 229 11. 11. Systems medicine and periodontal diseases - p. 249 12. 12. Bone translational medicine - p. 283 13. 13. Systems medicine and salivary gland diseases - p. 311 14. 14. Systems medicine, neuropathic oral diseases, and orofacial pain - p. 337 15. 15. Chronic systemic symptoms in cancer patients - p. 353 16. 16. Oral toxicities of cancer treatment - p. 371 17. 17. Stem cells and regenerative medicine - p. 387 18. 18. Translating concepts of systems medicine to the clinic - p. 409 19. Index - p. 429
Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others.
In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.
1. 1. Introduction to systems medicine - p. 1 2. 2. System biology - p. 9 3. 3. Genomic foundation for medical and oral disease translation to clinical assessment - p. 17 4. 4. Proteomics - p. 93 5. 5. Metabolomics in head and neck cancer: A summary of findings - p. 119 6. 6. Microbiomics - p. 137 7. 7. Epigenetics and oral disease - p. 163 8. 8. Systems pharmacology - p. 207 9. 9. Functional “omics” for systems medicine - p. 219 10. 10. Analytic methods for systems medicine - p. 229 11. 11. Systems medicine and periodontal diseases - p. 249 12. 12. Bone translational medicine - p. 283 13. 13. Systems medicine and salivary gland diseases - p. 311 14. 14. Systems medicine, neuropathic oral diseases, and orofacial pain - p. 337 15. 15. Chronic systemic symptoms in cancer patients - p. 353 16. 16. Oral toxicities of cancer treatment - p. 371 17. 17. Stem cells and regenerative medicine - p. 387 18. 18. Translating concepts of systems medicine to the clinic - p. 409 19. Index - p. 429
