Transplant Oncology: A Frontier in Multidisciplinary Cancer Care summarizes new and evolving scientific findings and discoveries in the field of cancer and transplants and gives guidance on future directions and related research. With a strong focus on transplant oncology, the book examines new and evolving topics, including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field such as using circulating tumor DNA (ctDNA) as a tool for minimal disease detection, surveillance, and treatment response evaluation as well as rejection assessment and detection in transplant patient for oncological indications. Sections cover applications of transplant medicine and surgery in oncology to improve patient survival outcome and quality of life. The book gives insight into anticancer strategies, such as initiating studies in genomics and cancer immunogenomics based on new insights in liver cancer. In addition, it describes how the adoption of surgical transplantation techniques in oncology has improved conventional resection and bridged the gap between tumor and transplant immunology. This is a must have reference for all those that want to be familiar and up-to-date with the dynamic changes in the field including practicing physicians, scientists, and trainees.
1. Introduction - p. xxxi 2. Section I: Transplant oncology: An evolving field in cancer care - p. xxxii 3. Chapter 1. Transplant oncology: Concept, history, and evolution - p. 3 4. Chapter 2. Prehistory of transplant oncology era - p. 17 5. Section II: Transplantations for oncological indications - p. 20 6. Chapter 3. Hepatocellular carcinoma - p. 27 7. Chapter 4. Cholangiocarcinoma and liver transplantation - p. 41 8. Chapter 5. Transplantation for metastatic colorectal cancer to liver - p. 51 9. Chapter 6. Liver transplantation for neuroendocrine neoplasms liver metastases - p. 63 10. Chapter 7. Hepatoblastoma - p. 79 11. Section III: Transplant oncology and immunotherapy - p. 83 12. Chapter 8. Transplant oncology and immunotherapy: Immunotherapy and liver transplants - p. 87 13. Chapter 9. B. Immunotherapy and kidney transplant - p. 107 14. Chapter 10. Immunotherapy and hematopoietic stem cell transplantation - p. 115 15. Chapter 11. Immunotherapy in the era of transplant oncology: Risks and complications - p. 135 16. Chapter 12. Immunotherapy and immunosuppressants: Considerations in the clinical practice - p. 149 17. Section IV: Transplant oncology and precision medicine - p. 153 18. Chapter 13. Molecular profiling and next-generation sequencing applications in transplant oncology - p. 159 19. Chapter 14. Circulating tumor DNA (ctDNA) as a new and evolving tool in solid organ transplantation - p. 175 20. Chapter 15. Cell-free DNA (cfDNA) biomarkers for solid organ transplant rejection - p. 181 21. Chapter 16. Artificial intelligence in transplant oncology - p. 191 22. Section V: Solid organ transplant and cancers considerations - p. 200 23. Chapter 17. De-novo malignancy post liver transplantation: Recent insights on epidemiology and surveillance strategies - p. 205 24. Chapter 18. History of cancer and transplant clearance: Considerations prior to transplantation - p. 215 25. Section VI: Surgical aspects of transplant oncology - p. 226 26. Chapter 19. Robotic surgery for liver cancer and applications in liver transplantation - p. 231 27. Chapter 20. Resection versus transplantation for intrahepatic and hilar cholangiocarcinoma - p. 239 28. Chapter 21. Liver transplantation for secondary liver cancers: Surgical considerations - p. 245 29. Chapter 22. New strategies for two-stage hepatectomy - p. 257 30. Chapter 23. Living donor liver transplantation - p. 263 31. Chapter 24. Patient characteristics and evaluations prior to liver transplantation - p. 277 32. Chapter 25. Challenges of liver transplantation for transplant oncology indications - p. 295 33. Chapter 26. Future of transplant oncology of the liver - p. 313 34. Index - p. 321
Transplant Oncology: A Frontier in Multidisciplinary Cancer Care summarizes new and evolving scientific findings and discoveries in the field of cancer and transplants and gives guidance on future directions and related research. With a strong focus on transplant oncology, the book examines new and evolving topics, including the utilization of immunotherapy in special patient populations as well as the clinical updates on new concepts in the field such as using circulating tumor DNA (ctDNA) as a tool for minimal disease detection, surveillance, and treatment response evaluation as well as rejection assessment and detection in transplant patient for oncological indications. Sections cover applications of transplant medicine and surgery in oncology to improve patient survival outcome and quality of life. The book gives insight into anticancer strategies, such as initiating studies in genomics and cancer immunogenomics based on new insights in liver cancer. In addition, it describes how the adoption of surgical transplantation techniques in oncology has improved conventional resection and bridged the gap between tumor and transplant immunology. This is a must have reference for all those that want to be familiar and up-to-date with the dynamic changes in the field including practicing physicians, scientists, and trainees.
1. Introduction - p. xxxi 2. Section I: Transplant oncology: An evolving field in cancer care - p. xxxii 3. Chapter 1. Transplant oncology: Concept, history, and evolution - p. 3 4. Chapter 2. Prehistory of transplant oncology era - p. 17 5. Section II: Transplantations for oncological indications - p. 20 6. Chapter 3. Hepatocellular carcinoma - p. 27 7. Chapter 4. Cholangiocarcinoma and liver transplantation - p. 41 8. Chapter 5. Transplantation for metastatic colorectal cancer to liver - p. 51 9. Chapter 6. Liver transplantation for neuroendocrine neoplasms liver metastases - p. 63 10. Chapter 7. Hepatoblastoma - p. 79 11. Section III: Transplant oncology and immunotherapy - p. 83 12. Chapter 8. Transplant oncology and immunotherapy: Immunotherapy and liver transplants - p. 87 13. Chapter 9. B. Immunotherapy and kidney transplant - p. 107 14. Chapter 10. Immunotherapy and hematopoietic stem cell transplantation - p. 115 15. Chapter 11. Immunotherapy in the era of transplant oncology: Risks and complications - p. 135 16. Chapter 12. Immunotherapy and immunosuppressants: Considerations in the clinical practice - p. 149 17. Section IV: Transplant oncology and precision medicine - p. 153 18. Chapter 13. Molecular profiling and next-generation sequencing applications in transplant oncology - p. 159 19. Chapter 14. Circulating tumor DNA (ctDNA) as a new and evolving tool in solid organ transplantation - p. 175 20. Chapter 15. Cell-free DNA (cfDNA) biomarkers for solid organ transplant rejection - p. 181 21. Chapter 16. Artificial intelligence in transplant oncology - p. 191 22. Section V: Solid organ transplant and cancers considerations - p. 200 23. Chapter 17. De-novo malignancy post liver transplantation: Recent insights on epidemiology and surveillance strategies - p. 205 24. Chapter 18. History of cancer and transplant clearance: Considerations prior to transplantation - p. 215 25. Section VI: Surgical aspects of transplant oncology - p. 226 26. Chapter 19. Robotic surgery for liver cancer and applications in liver transplantation - p. 231 27. Chapter 20. Resection versus transplantation for intrahepatic and hilar cholangiocarcinoma - p. 239 28. Chapter 21. Liver transplantation for secondary liver cancers: Surgical considerations - p. 245 29. Chapter 22. New strategies for two-stage hepatectomy - p. 257 30. Chapter 23. Living donor liver transplantation - p. 263 31. Chapter 24. Patient characteristics and evaluations prior to liver transplantation - p. 277 32. Chapter 25. Challenges of liver transplantation for transplant oncology indications - p. 295 33. Chapter 26. Future of transplant oncology of the liver - p. 313 34. Index - p. 321
