Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
1. Part 1: Introduction to sirtuins - p. P1 2. 1. Sirtuin proteins: structure, functions, and evolutionary insights - p. 3 3. 2. Nicotinamide adenine dinucleotide-dependent enzymatic mechanisms and nicotinamide adenine dinucleotide precursors (nicotinamide mononucleotide, nicotinamide riboside) - p. 43 4. Part 2: Sirtuins and aging - p. P63 5. 3. Sirtuins in senescence, mitochondrial health, and longevity - p. 65 6. 4. DNA repair and genome maintenance via sirtuin pathways - p. 99 7. Part 3: Sirtuins in metabolic regulation - p. P139 8. 5. Sirtuins and energy homeostasis - p. 141 9. 6. Role of sirtuins in glucose and lipid metabolism - p. 183 10. 7. Sirtuins in caloric restriction and fasting responses - p. 215 11. Part 4: Sirtuins in disease pathology - p. P247 12. 8. Sirtuins in neurodegenerative diseases - p. 249 13. 9. Sirtuins in cardiovascular health - p. 291 14. 10. The role of sirtuins in cancer progression - p. 331 15. 11. Sirtuins in inflammation and autoimmunity - p. 363 16. Part 5: Therapeutic applications - p. P391 17. 12. Sirtuin modulators: small molecules and natural compounds - p. 393 18. 13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions - p. 409 19. 14. Translational perspectives in drug discovery - p. 441 20. Part 6: Future directions and challenges - p. P479 21. 15. Emerging trends in sirtuin research - p. 481 22. 16. Technological advancements in sirtuin analysis - p. 529 23. 17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology - p. 563 24. 18. Ethical and clinical implications of sirtuin therapies - p. 597 25. Author index - p. 611 26. Subject index - p. 631
Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
1. Part 1: Introduction to sirtuins - p. P1 2. 1. Sirtuin proteins: structure, functions, and evolutionary insights - p. 3 3. 2. Nicotinamide adenine dinucleotide-dependent enzymatic mechanisms and nicotinamide adenine dinucleotide precursors (nicotinamide mononucleotide, nicotinamide riboside) - p. 43 4. Part 2: Sirtuins and aging - p. P63 5. 3. Sirtuins in senescence, mitochondrial health, and longevity - p. 65 6. 4. DNA repair and genome maintenance via sirtuin pathways - p. 99 7. Part 3: Sirtuins in metabolic regulation - p. P139 8. 5. Sirtuins and energy homeostasis - p. 141 9. 6. Role of sirtuins in glucose and lipid metabolism - p. 183 10. 7. Sirtuins in caloric restriction and fasting responses - p. 215 11. Part 4: Sirtuins in disease pathology - p. P247 12. 8. Sirtuins in neurodegenerative diseases - p. 249 13. 9. Sirtuins in cardiovascular health - p. 291 14. 10. The role of sirtuins in cancer progression - p. 331 15. 11. Sirtuins in inflammation and autoimmunity - p. 363 16. Part 5: Therapeutic applications - p. P391 17. 12. Sirtuin modulators: small molecules and natural compounds - p. 393 18. 13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions - p. 409 19. 14. Translational perspectives in drug discovery - p. 441 20. Part 6: Future directions and challenges - p. P479 21. 15. Emerging trends in sirtuin research - p. 481 22. 16. Technological advancements in sirtuin analysis - p. 529 23. 17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology - p. 563 24. 18. Ethical and clinical implications of sirtuin therapies - p. 597 25. Author index - p. 611 26. Subject index - p. 631
