Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.
Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.
Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.
Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.
1. Chapter 1. An Introduction to Validamycins and Their Derivatives - p. 1 2. Chapter 2. Production of Validamycins - p. 9 3. Abstract - p. 9 4. 2.1 Discovery of Validamycins - p. 9 5. 2.2 Microbes for Producing Validamycins - p. 9 6. 2.3 Production and Isolation of Validamycins and Related Natural Compounds - p. 22 7. 2.4 Structures, Characterization, and Properties of Validamycins and Related Natural Compounds - p. 28 8. 2.5 Biosynthesis of Validamycins - p. 39 9. 2.6 Detection of Validamycin A - p. 60 10. 2.7 Microbial Degradation of Validamycin A - p. 75 11. 2.8 Cloning, Expression, and Deficiency of Genes in the Validamycin Biosynthesis and Their Applications - p. 76 12. 2.9 Fermentation Process for Production of Validamycins - p. 90 13. References - p. 106 14. Chapter 3. Bioactivities of Validamycins and Related Natural Compounds - p. 115 15. Chapter 4. Chemical Synthesis of Validamycin and Related Natural Compounds - p. 165 16. Chapter 5. Voglibose: An Important Drug for Type 2 Diabetes - p. 237 17. Chapter 6. N-Octyl-β-Valienamine and N-Octyl-4-epi-β-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy - p. 279 18. Chapter 7. Prospects and Concluding Remarks - p. 313 19. Index - p. 315
Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.
Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.
Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.
Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.
1. Chapter 1. An Introduction to Validamycins and Their Derivatives - p. 1 2. Chapter 2. Production of Validamycins - p. 9 3. Abstract - p. 9 4. 2.1 Discovery of Validamycins - p. 9 5. 2.2 Microbes for Producing Validamycins - p. 9 6. 2.3 Production and Isolation of Validamycins and Related Natural Compounds - p. 22 7. 2.4 Structures, Characterization, and Properties of Validamycins and Related Natural Compounds - p. 28 8. 2.5 Biosynthesis of Validamycins - p. 39 9. 2.6 Detection of Validamycin A - p. 60 10. 2.7 Microbial Degradation of Validamycin A - p. 75 11. 2.8 Cloning, Expression, and Deficiency of Genes in the Validamycin Biosynthesis and Their Applications - p. 76 12. 2.9 Fermentation Process for Production of Validamycins - p. 90 13. References - p. 106 14. Chapter 3. Bioactivities of Validamycins and Related Natural Compounds - p. 115 15. Chapter 4. Chemical Synthesis of Validamycin and Related Natural Compounds - p. 165 16. Chapter 5. Voglibose: An Important Drug for Type 2 Diabetes - p. 237 17. Chapter 6. N-Octyl-β-Valienamine and N-Octyl-4-epi-β-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy - p. 279 18. Chapter 7. Prospects and Concluding Remarks - p. 313 19. Index - p. 315
