Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources.
The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. Water Extraction of Bioactive Compounds: From Plants to Drug Development is a detailed guide to the fundamental concepts and considerations needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables.
Beginning with an introduction to plants as sources of drugs, the book highlights the need for a move towards both more rational and greener techniques in the field, and presents multiple innovative water-based strategies for the discovery and extraction of bioactive constituents of botanicals. A broad range of available techniques are reviewed, including conventional and pressurized hot water extraction techniques, intensified processes such as microwave-assisted, ultrasound-assisted processes, and enzyme assisted extraction, and processes using combined techniques.
1. Chapter 1. Introduction - p. 1 2. 1. Botanical Therapy - p. 1 3. 2. Sustainable Sources and Utilization of Bioactives - p. 6 4. 3. Extraction - p. 7 5. 4. Advanced Extraction Processes - p. 19 6. Chapter 2. Therapeutic Compounds From Plants Using Subcritical Water Technology - p. 51 7. Chapter 3. Hydrolysis of Biopolymers in Near-Critical and Subcritical Water - p. 69 8. Chapter 4. Subcritical Water Extraction and Neoformation of Antioxidants - p. 109 9. Chapter 5. Extraction of Oligosaccharides With Prebiotic Properties From Agro-Industrial Wastes - p. 131 10. Chapter 6. Microwave-Assisted Water Extraction - p. 163 11. 1. Introduction - p. 163 12. 2. Fundamentals of Microwave-Assisted Extraction - p. 164 13. 3. Types of Technologies and Configurations - p. 167 14. 4. Applications of Microwave-Assisted Water Extraction - p. 173 15. 5. Variables Affecting the Microwave-Assisted Water Extraction - p. 183 16. 6. Final Remarks - p. 187 17. Chapter 7. Microwave-Assisted Water Extraction of Carbohydrates From Unutilized Biomass - p. 199 18. Chapter 8. Microwave-Assisted Extraction of Flavonoids - p. 221 19. Chapter 9. Microwave-Assisted Extraction of Betalains - p. 245 20. Chapter 10. Microwave-Assisted Pressurized Hot Water Extraction of Alkaloids - p. 269 21. Chapter 11. Fundamentals of Ultrasound-Assisted Extraction - p. 291 22. Chapter 12. Ultrasound-Assisted Extraction of Bioactive Carbohydrates - p. 317 23. Chapter 13. Enzyme-Assisted Aqueous Extraction Processes - p. 333 24. 1. Introduction - p. 333 25. 2. Cell Walls and Hydrolytic Enzymes - p. 334 26. 3. Applications of enzyme-assisted extraction - p. 338 27. 4. Variables Affecting the Process - p. 353 28. 5. Conclusions and Perspectives - p. 358 29. Chapter 14. Enzyme-Assisted Extraction of Phenolic Compounds - p. 369 30. Chapter 15. Silymarin Extraction From Silybum marianum L. Gaertner - p. 385 31. Chapter 16. Potential of Novel Technologies for Aqueous Extraction of Plant Bioactives - p. 399 32. Chapter 17. Combination of Water-Based Extraction Technologies - p. 421 33. Index - p. 451
Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources.
The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. Water Extraction of Bioactive Compounds: From Plants to Drug Development is a detailed guide to the fundamental concepts and considerations needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables.
Beginning with an introduction to plants as sources of drugs, the book highlights the need for a move towards both more rational and greener techniques in the field, and presents multiple innovative water-based strategies for the discovery and extraction of bioactive constituents of botanicals. A broad range of available techniques are reviewed, including conventional and pressurized hot water extraction techniques, intensified processes such as microwave-assisted, ultrasound-assisted processes, and enzyme assisted extraction, and processes using combined techniques.
1. Chapter 1. Introduction - p. 1 2. 1. Botanical Therapy - p. 1 3. 2. Sustainable Sources and Utilization of Bioactives - p. 6 4. 3. Extraction - p. 7 5. 4. Advanced Extraction Processes - p. 19 6. Chapter 2. Therapeutic Compounds From Plants Using Subcritical Water Technology - p. 51 7. Chapter 3. Hydrolysis of Biopolymers in Near-Critical and Subcritical Water - p. 69 8. Chapter 4. Subcritical Water Extraction and Neoformation of Antioxidants - p. 109 9. Chapter 5. Extraction of Oligosaccharides With Prebiotic Properties From Agro-Industrial Wastes - p. 131 10. Chapter 6. Microwave-Assisted Water Extraction - p. 163 11. 1. Introduction - p. 163 12. 2. Fundamentals of Microwave-Assisted Extraction - p. 164 13. 3. Types of Technologies and Configurations - p. 167 14. 4. Applications of Microwave-Assisted Water Extraction - p. 173 15. 5. Variables Affecting the Microwave-Assisted Water Extraction - p. 183 16. 6. Final Remarks - p. 187 17. Chapter 7. Microwave-Assisted Water Extraction of Carbohydrates From Unutilized Biomass - p. 199 18. Chapter 8. Microwave-Assisted Extraction of Flavonoids - p. 221 19. Chapter 9. Microwave-Assisted Extraction of Betalains - p. 245 20. Chapter 10. Microwave-Assisted Pressurized Hot Water Extraction of Alkaloids - p. 269 21. Chapter 11. Fundamentals of Ultrasound-Assisted Extraction - p. 291 22. Chapter 12. Ultrasound-Assisted Extraction of Bioactive Carbohydrates - p. 317 23. Chapter 13. Enzyme-Assisted Aqueous Extraction Processes - p. 333 24. 1. Introduction - p. 333 25. 2. Cell Walls and Hydrolytic Enzymes - p. 334 26. 3. Applications of enzyme-assisted extraction - p. 338 27. 4. Variables Affecting the Process - p. 353 28. 5. Conclusions and Perspectives - p. 358 29. Chapter 14. Enzyme-Assisted Extraction of Phenolic Compounds - p. 369 30. Chapter 15. Silymarin Extraction From Silybum marianum L. Gaertner - p. 385 31. Chapter 16. Potential of Novel Technologies for Aqueous Extraction of Plant Bioactives - p. 399 32. Chapter 17. Combination of Water-Based Extraction Technologies - p. 421 33. Index - p. 451
