Considered the definitive reference on canine and feline oncology, Withrow & MacEwen's Small Animal Clinical Oncology, 6th Edition focuses on the most effective, cutting-edge techniques. This comprehensive textbook gives you a complete understanding of cancer in dogs and cats — what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice today. The thoroughly updated sixth edition includes information on the complications of cancer, pain management, and the latest treatment modalities — preparing general practitioners to diagnose and treat pets rather than referring them to a specialist. With important updates on recently approved and in-development drugs, and new co-authors adding their own unique perspectives, this user-friendly text is a must-have resource for current, evidence-based therapeutic strategies on canine and feline oncology.
1. Introduction - p. xix 2. Part I. The Biology and Pathogenesis of Cancer - p. xx 3. 1. The Etiology of Cancer - p. 1 4. 2. Tumor Biology and Metastasis - p. 36 5. 3. The Pathology of Neoplasia - p. 61 6. 4. Epidemiology and the Evidence-Based Medicine Approach - p. 81 7. 5. Paraneoplastic Syndromes - p. 98 8. Part II. Diagnostic Procedures for the Cancer Patient - p. 112 9. 6. Diagnostic Imaging in Oncology - p. 113 10. 7. Diagnostic Cytopathology in Clinical Oncology - p. 126 11. 8. Molecular Diagnostics - p. 146 12. 9. Biopsy and Sentinel Lymph Node Mapping Principles - p. 158 13. Part III. Therapeutic Modalities for the Cancer Patient - p. 163 14. 10. Surgical Oncology - p. 164 15. 11. Interventional Oncology - p. 174 16. 12. Cancer Chemotherapy - p. 182 17. 13. Radiation Oncology - p. 209 18. 14. Cancer Immunotherapy - p. 231 19. 15. Molecular/Targeted Therapy of Cancer - p. 251 20. Section A: Gene Therapy for Cancer - p. 251 21. Delivery Vehicles for Cancer Gene Therapy - p. 251 22. Gene Therapy Strategies for Cancer - p. 254 23. Safety Considerations in Gene Therapy - p. 257 24. Conclusions - p. 257 25. Section B: Signal Transduction and Cancer - p. 257 26. Protein Kinases and Normal Cells - p. 257 27. Protein Kinases and Cancer Cells - p. 259 28. Inhibition of Kinases - p. 261 29. Kinase Inhibitors in Veterinary Medicine - p. 262 30. Conclusion - p. 263 31. Section C: Antiangiogenic and Metronomic Therapy - p. 263 32. Antiangiogenic Therapy - p. 263 33. Clinical Trial Evaluation - p. 266 34. Section D: Novel and Emerging Therapeutic Agents - p. 268 35. DNA Methylation - p. 269 36. Poly ADP-Ribose Polymerase and Poly ADP-Ribose Glycohydrolase - p. 272 37. 16. Supportive Care for the Cancer Patient - p. 286 38. Section A: Management of Chronic Cancer Pain - p. 286 39. Mechanisms of Cancer-Induced Pain - p. 286 40. Pain as a Consequence of Cancer Therapy - p. 286 41. Assessment of Cancer Pain - p. 288 42. Drugs and Strategies Used for Management of Pain in Cancer Patients - p. 290 43. Palliative-Intent Radiation Therapy - p. 297 44. Pharmacologic Desensitization Strategy - p. 298 45. Acupuncture - p. 298 46. Future Analgesic Therapies - p. 298 47. Section B: Nutritional Management of the Cancer Patient - p. 300 48. Metabolism of Cancer - p. 300 49. Anorexia and Cachexia - p. 300 50. Epidemiology, Prevention, and Risk Factors - p. 301 51. Implementing a Nutritional Plan for the Oncology Patient - p. 302 52. Feeding the Hospitalized Oncology Patient - p. 304 53. Coax Feeding and Pharmacologic Appetite Stimulation - p. 304 54. Assisted Enteral Support - p. 304 55. Parenteral Support - p. 305 56. Nutritional Support in the Cancer Patient - p. 306 57. Amino Acids - p. 308 58. Section C: Relationship-Centered Approach to Cancer Communication - p. 310 59. Paradigm Shift: Paternalism to Partnership - p. 311 60. Relationship-Centered Care - p. 311 61. Client Uncertainty - p. 312 62. Veterinarian Expressions of Uncertainty - p. 313 63. Client Expectations - p. 313 64. Core Communication Skills for Cancer Communication - p. 313 65. Approaches to Cancer Conversations - p. 316 66. Conclusion - p. 319 67. 17. Integrative Oncology - p. 330 68. 18. Clinical Trials and Developmental Therapeutics - p. 340 69. Part IV. Specific Malignancies in the Small Animal Patient - p. 351 70. 19. Tumors of the Skin and Subcutaneous Tissues - p. 352 71. 20. Melanoma - p. 367 72. 21. Mast Cell Tumors - p. 382 73. 22. Soft Tissue Sarcomas - p. 404 74. 23. Cancer of the Gastrointestinal Tract - p. 432 75. Section A: Oral Tumors - p. 432 76. Pathology and Natural Behavior - p. 432 77. History and Clinical Signs - p. 435 78. Diagnostic Techniques and Workup - p. 436 79. Treatment - p. 437 80. Prognosis - p. 440 81. Selected Sites or Cancer Conditions in the Oral Cavity - p. 445 82. Comparative Aspects202 - p. 448 83. Section B: Salivary Gland Neoplasia - p. 448 84. Pathology - p. 448 85. History and Clinical Signs - p. 448 86. Diagnostic Techniques and Workup - p. 448 87. Therapy - p. 448 88. Prognosis - p. 449 89. Comparative Aspects - p. 449 90. Section C: Esophageal Tumors - p. 449 91. Pathology and Behavior - p. 449 92. History and Clinical Signs - p. 449 93. Diagnostic Tests and Workup - p. 449 94. Treatment Options - p. 450 95. Prognosis - p. 450 96. Comparative Aspects - p. 451 97. Section D: Exocrine Pancreatic Cancer - p. 451 98. Pathology and Natural Behavior - p. 451 99. History and Clinical Signs - p. 451 100. Diagnostic Techniques and Workup - p. 451 101. Therapy - p. 451 102. Prognosis - p. 452 103. Comparative Aspects277–279 - p. 452 104. Section E: Gastric Cancer - p. 452 105. Pathology and Natural Behavior - p. 452 106. History and Clinical Signs - p. 453 107. Diagnostic Techniques and Workup - p. 453 108. Treatment - p. 453 109. Prognosis - p. 454 110. Comparative Aspects - p. 454 111. Section F: Hepatobiliary Tumors - p. 454 112. Pathology and Natural Behavior - p. 455 113. History and Clinical Signs - p. 456 114. Diagnostic Techniques and Workup - p. 457 115. Therapy and Prognosis - p. 458 116. Comparative Aspects - p. 460 117. Section G: Intestinal Tumors - p. 460 118. Pathology and Natural Behavior - p. 461 119. History and Clinical Signs - p. 462 120. Diagnostic Techniques and Workup - p. 463 121. Therapy and Prognosis - p. 465 122. Prognostic Factors - p. 467 123. Comparative Aspects - p. 467 124. Section H: Perianal Tumors - p. 468 125. Perianal Adenoma and Adenocarcinoma - p. 468 126. Apocrine Gland Anal Sac Adenocarcinoma and Other Tumors of the Anal Sac - p. 470 127. Comparative Aspects645–648 - p. 476 128. 24. Tumors of the Respiratory System - p. 492 129. 25. Tumors of the Skeletal System - p. 524 130. Osteosarcoma in Dogs - p. 524 131. Primary Bone Tumors of Cats - p. 553 132. 26. Tumors of the Endocrine System - p. 565 133. Pituitary Tumors - p. 565 134. Pituitary Corticotroph Tumors: Hyperadrenocorticism - p. 565 135. Pituitary Somatotroph Tumors (Feline Acromegaly) - p. 569 136. Adrenal Gland Neoplasia - p. 571 137. Thyroid Gland Neoplasia in Dogs - p. 575 138. Thyroid Gland Neoplasia in Cats - p. 577 139. Parathyroid Tumors - p. 580 140. Pancreatic Beta-Cell Tumors (Insulinomas) - p. 582 141. Gastrointestinal Endocrine Tumors - p. 584 142. 27. Tumors of the Female Reproductive System - p. 597 143. 28. Tumors of the Mammary Gland - p. 604 144. 29. Tumors of the Male Reproductive System - p. 626 145. 30. Tumors of the Urinary System - p. 645 146. 31. Tumors of the Nervous System - p. 657 147. 32. Ocular Tumors - p. 675 148. 33. Hematopoietic Tumors - p. 688 149. Section A: Canine Lymphoma and Lymphocytic Leukemias - p. 688 150. Lymphoma - p. 752 151. Lymphocytic Leukemia - p. 688 152. Section B: Feline Lymphoma and Leukemia - p. 740 153. Lymphoma - p. 715 154. Alimentary/Gastrointestinal Lymphoma - p. 718 155. Peripheral Nodal Lymphoma in Cats - p. 723 156. Extranodal Lymphoma - p. 724 157. Feline Leukemias, Myeloproliferative Disorders, and Myelodysplasia - p. 729 158. Section C: Canine Acute Myeloid Leukemia, Myeloproliferative Neoplasms, and Myelodysplasia - p. 712 159. Incidence and Risk Factors - p. 730 160. Pathology and Natural Behavior - p. 731 161. Acute Myeloid Leukemia - p. 732 162. Myeloproliferative Neoplasms - p. 734 163. Other Bone Marrow Disorders - p. 735 164. Section D: Myeloma-Related Disorders - p. 712 165. Multiple Myeloma - p. 739 166. Solitary and Extramedullary Plasmacytic Tumors - p. 749 167. 34. Miscellaneous Tumors - p. 773 168. Section A: Hemangiosarcoma - p. 773 169. Pathology and Natural Behavior - p. 773 170. History and Clinical Signs - p. 774 171. Diagnostic Techniques and Workup - p. 774 172. Treatment - p. 776 173. Prognosis - p. 777 174. Conclusion - p. 778 175. Comparative Aspects - p. 778 176. Section B: Thymoma - p. 778 177. Pathology and Natural Behavior - p. 779 178. History and Clinical Signs - p. 779 179. Diagnostic Techniques and Workup - p. 779 180. Therapy - p. 780 181. Prognosis - p. 780 182. Comparative Aspects - p. 780 183. Section C: Canine Transmissible Venereal Tumor - p. 781 184. Pathology and Natural Behavior - p. 781 185. History and Clinical Signs - p. 782 186. Diagnostic Techniques and Workup - p. 783 187. Therapy - p. 783 188. Prognosis - p. 784 189. Section D: Mesothelioma - p. 784 190. Pathology and Natural Behavior - p. 785 191. History and Clinical Signs - p. 785 192. Diagnostic Techniques and Workup - p. 785 193. Treatment and Prognosis - p. 786 194. Comparative Aspects - p. 787 195. Section E: Neoplasia of the Heart - p. 787 196. Pathology and Natural Behavior - p. 787 197. History and Clinical Signs - p. 788 198. Diagnostic Techniques and Workup - p. 788 199. Therapy - p. 790 200. Prognosis - p. 791 201. Comparative Aspects - p. 791 202. Section F: Histiocytic Diseases - p. 791 203. Histiocytic Differentiation - p. 791 204. Immunophenotyping - p. 793 205. Cutaneous Histiocytoma - p. 793 206. Cutaneous Langerhans Cell Histiocytosis - p. 793 207. Reactive Histiocytosis - p. 794 208. Histiocytic Sarcoma - p. 794 209. Hemophagocytic Histiocytic Sarcoma - p. 797 210. Feline Histiocytic Diseases - p. 797 211. Comparative Aspects - p. 798 212. Index - p. 811
Considered the definitive reference on canine and feline oncology, Withrow & MacEwen's Small Animal Clinical Oncology, 6th Edition focuses on the most effective, cutting-edge techniques. This comprehensive textbook gives you a complete understanding of cancer in dogs and cats — what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice today. The thoroughly updated sixth edition includes information on the complications of cancer, pain management, and the latest treatment modalities — preparing general practitioners to diagnose and treat pets rather than referring them to a specialist. With important updates on recently approved and in-development drugs, and new co-authors adding their own unique perspectives, this user-friendly text is a must-have resource for current, evidence-based therapeutic strategies on canine and feline oncology.
1. Introduction - p. xix 2. Part I. The Biology and Pathogenesis of Cancer - p. xx 3. 1. The Etiology of Cancer - p. 1 4. 2. Tumor Biology and Metastasis - p. 36 5. 3. The Pathology of Neoplasia - p. 61 6. 4. Epidemiology and the Evidence-Based Medicine Approach - p. 81 7. 5. Paraneoplastic Syndromes - p. 98 8. Part II. Diagnostic Procedures for the Cancer Patient - p. 112 9. 6. Diagnostic Imaging in Oncology - p. 113 10. 7. Diagnostic Cytopathology in Clinical Oncology - p. 126 11. 8. Molecular Diagnostics - p. 146 12. 9. Biopsy and Sentinel Lymph Node Mapping Principles - p. 158 13. Part III. Therapeutic Modalities for the Cancer Patient - p. 163 14. 10. Surgical Oncology - p. 164 15. 11. Interventional Oncology - p. 174 16. 12. Cancer Chemotherapy - p. 182 17. 13. Radiation Oncology - p. 209 18. 14. Cancer Immunotherapy - p. 231 19. 15. Molecular/Targeted Therapy of Cancer - p. 251 20. Section A: Gene Therapy for Cancer - p. 251 21. Delivery Vehicles for Cancer Gene Therapy - p. 251 22. Gene Therapy Strategies for Cancer - p. 254 23. Safety Considerations in Gene Therapy - p. 257 24. Conclusions - p. 257 25. Section B: Signal Transduction and Cancer - p. 257 26. Protein Kinases and Normal Cells - p. 257 27. Protein Kinases and Cancer Cells - p. 259 28. Inhibition of Kinases - p. 261 29. Kinase Inhibitors in Veterinary Medicine - p. 262 30. Conclusion - p. 263 31. Section C: Antiangiogenic and Metronomic Therapy - p. 263 32. Antiangiogenic Therapy - p. 263 33. Clinical Trial Evaluation - p. 266 34. Section D: Novel and Emerging Therapeutic Agents - p. 268 35. DNA Methylation - p. 269 36. Poly ADP-Ribose Polymerase and Poly ADP-Ribose Glycohydrolase - p. 272 37. 16. Supportive Care for the Cancer Patient - p. 286 38. Section A: Management of Chronic Cancer Pain - p. 286 39. Mechanisms of Cancer-Induced Pain - p. 286 40. Pain as a Consequence of Cancer Therapy - p. 286 41. Assessment of Cancer Pain - p. 288 42. Drugs and Strategies Used for Management of Pain in Cancer Patients - p. 290 43. Palliative-Intent Radiation Therapy - p. 297 44. Pharmacologic Desensitization Strategy - p. 298 45. Acupuncture - p. 298 46. Future Analgesic Therapies - p. 298 47. Section B: Nutritional Management of the Cancer Patient - p. 300 48. Metabolism of Cancer - p. 300 49. Anorexia and Cachexia - p. 300 50. Epidemiology, Prevention, and Risk Factors - p. 301 51. Implementing a Nutritional Plan for the Oncology Patient - p. 302 52. Feeding the Hospitalized Oncology Patient - p. 304 53. Coax Feeding and Pharmacologic Appetite Stimulation - p. 304 54. Assisted Enteral Support - p. 304 55. Parenteral Support - p. 305 56. Nutritional Support in the Cancer Patient - p. 306 57. Amino Acids - p. 308 58. Section C: Relationship-Centered Approach to Cancer Communication - p. 310 59. Paradigm Shift: Paternalism to Partnership - p. 311 60. Relationship-Centered Care - p. 311 61. Client Uncertainty - p. 312 62. Veterinarian Expressions of Uncertainty - p. 313 63. Client Expectations - p. 313 64. Core Communication Skills for Cancer Communication - p. 313 65. Approaches to Cancer Conversations - p. 316 66. Conclusion - p. 319 67. 17. Integrative Oncology - p. 330 68. 18. Clinical Trials and Developmental Therapeutics - p. 340 69. Part IV. Specific Malignancies in the Small Animal Patient - p. 351 70. 19. Tumors of the Skin and Subcutaneous Tissues - p. 352 71. 20. Melanoma - p. 367 72. 21. Mast Cell Tumors - p. 382 73. 22. Soft Tissue Sarcomas - p. 404 74. 23. Cancer of the Gastrointestinal Tract - p. 432 75. Section A: Oral Tumors - p. 432 76. Pathology and Natural Behavior - p. 432 77. History and Clinical Signs - p. 435 78. Diagnostic Techniques and Workup - p. 436 79. Treatment - p. 437 80. Prognosis - p. 440 81. Selected Sites or Cancer Conditions in the Oral Cavity - p. 445 82. Comparative Aspects202 - p. 448 83. Section B: Salivary Gland Neoplasia - p. 448 84. Pathology - p. 448 85. History and Clinical Signs - p. 448 86. Diagnostic Techniques and Workup - p. 448 87. Therapy - p. 448 88. Prognosis - p. 449 89. Comparative Aspects - p. 449 90. Section C: Esophageal Tumors - p. 449 91. Pathology and Behavior - p. 449 92. History and Clinical Signs - p. 449 93. Diagnostic Tests and Workup - p. 449 94. Treatment Options - p. 450 95. Prognosis - p. 450 96. Comparative Aspects - p. 451 97. Section D: Exocrine Pancreatic Cancer - p. 451 98. Pathology and Natural Behavior - p. 451 99. History and Clinical Signs - p. 451 100. Diagnostic Techniques and Workup - p. 451 101. Therapy - p. 451 102. Prognosis - p. 452 103. Comparative Aspects277–279 - p. 452 104. Section E: Gastric Cancer - p. 452 105. Pathology and Natural Behavior - p. 452 106. History and Clinical Signs - p. 453 107. Diagnostic Techniques and Workup - p. 453 108. Treatment - p. 453 109. Prognosis - p. 454 110. Comparative Aspects - p. 454 111. Section F: Hepatobiliary Tumors - p. 454 112. Pathology and Natural Behavior - p. 455 113. History and Clinical Signs - p. 456 114. Diagnostic Techniques and Workup - p. 457 115. Therapy and Prognosis - p. 458 116. Comparative Aspects - p. 460 117. Section G: Intestinal Tumors - p. 460 118. Pathology and Natural Behavior - p. 461 119. History and Clinical Signs - p. 462 120. Diagnostic Techniques and Workup - p. 463 121. Therapy and Prognosis - p. 465 122. Prognostic Factors - p. 467 123. Comparative Aspects - p. 467 124. Section H: Perianal Tumors - p. 468 125. Perianal Adenoma and Adenocarcinoma - p. 468 126. Apocrine Gland Anal Sac Adenocarcinoma and Other Tumors of the Anal Sac - p. 470 127. Comparative Aspects645–648 - p. 476 128. 24. Tumors of the Respiratory System - p. 492 129. 25. Tumors of the Skeletal System - p. 524 130. Osteosarcoma in Dogs - p. 524 131. Primary Bone Tumors of Cats - p. 553 132. 26. Tumors of the Endocrine System - p. 565 133. Pituitary Tumors - p. 565 134. Pituitary Corticotroph Tumors: Hyperadrenocorticism - p. 565 135. Pituitary Somatotroph Tumors (Feline Acromegaly) - p. 569 136. Adrenal Gland Neoplasia - p. 571 137. Thyroid Gland Neoplasia in Dogs - p. 575 138. Thyroid Gland Neoplasia in Cats - p. 577 139. Parathyroid Tumors - p. 580 140. Pancreatic Beta-Cell Tumors (Insulinomas) - p. 582 141. Gastrointestinal Endocrine Tumors - p. 584 142. 27. Tumors of the Female Reproductive System - p. 597 143. 28. Tumors of the Mammary Gland - p. 604 144. 29. Tumors of the Male Reproductive System - p. 626 145. 30. Tumors of the Urinary System - p. 645 146. 31. Tumors of the Nervous System - p. 657 147. 32. Ocular Tumors - p. 675 148. 33. Hematopoietic Tumors - p. 688 149. Section A: Canine Lymphoma and Lymphocytic Leukemias - p. 688 150. Lymphoma - p. 752 151. Lymphocytic Leukemia - p. 688 152. Section B: Feline Lymphoma and Leukemia - p. 740 153. Lymphoma - p. 715 154. Alimentary/Gastrointestinal Lymphoma - p. 718 155. Peripheral Nodal Lymphoma in Cats - p. 723 156. Extranodal Lymphoma - p. 724 157. Feline Leukemias, Myeloproliferative Disorders, and Myelodysplasia - p. 729 158. Section C: Canine Acute Myeloid Leukemia, Myeloproliferative Neoplasms, and Myelodysplasia - p. 712 159. Incidence and Risk Factors - p. 730 160. Pathology and Natural Behavior - p. 731 161. Acute Myeloid Leukemia - p. 732 162. Myeloproliferative Neoplasms - p. 734 163. Other Bone Marrow Disorders - p. 735 164. Section D: Myeloma-Related Disorders - p. 712 165. Multiple Myeloma - p. 739 166. Solitary and Extramedullary Plasmacytic Tumors - p. 749 167. 34. Miscellaneous Tumors - p. 773 168. Section A: Hemangiosarcoma - p. 773 169. Pathology and Natural Behavior - p. 773 170. History and Clinical Signs - p. 774 171. Diagnostic Techniques and Workup - p. 774 172. Treatment - p. 776 173. Prognosis - p. 777 174. Conclusion - p. 778 175. Comparative Aspects - p. 778 176. Section B: Thymoma - p. 778 177. Pathology and Natural Behavior - p. 779 178. History and Clinical Signs - p. 779 179. Diagnostic Techniques and Workup - p. 779 180. Therapy - p. 780 181. Prognosis - p. 780 182. Comparative Aspects - p. 780 183. Section C: Canine Transmissible Venereal Tumor - p. 781 184. Pathology and Natural Behavior - p. 781 185. History and Clinical Signs - p. 782 186. Diagnostic Techniques and Workup - p. 783 187. Therapy - p. 783 188. Prognosis - p. 784 189. Section D: Mesothelioma - p. 784 190. Pathology and Natural Behavior - p. 785 191. History and Clinical Signs - p. 785 192. Diagnostic Techniques and Workup - p. 785 193. Treatment and Prognosis - p. 786 194. Comparative Aspects - p. 787 195. Section E: Neoplasia of the Heart - p. 787 196. Pathology and Natural Behavior - p. 787 197. History and Clinical Signs - p. 788 198. Diagnostic Techniques and Workup - p. 788 199. Therapy - p. 790 200. Prognosis - p. 791 201. Comparative Aspects - p. 791 202. Section F: Histiocytic Diseases - p. 791 203. Histiocytic Differentiation - p. 791 204. Immunophenotyping - p. 793 205. Cutaneous Histiocytoma - p. 793 206. Cutaneous Langerhans Cell Histiocytosis - p. 793 207. Reactive Histiocytosis - p. 794 208. Histiocytic Sarcoma - p. 794 209. Hemophagocytic Histiocytic Sarcoma - p. 797 210. Feline Histiocytic Diseases - p. 797 211. Comparative Aspects - p. 798 212. Index - p. 811
