Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout.
1. Introduction - p. 369 2. Making Foie Gras - p. 371 3. Nonalcoholic Fatty Liver Disease: An Adiposopathy - p. 374 4. Nonalcoholic Fatty Liver Disease and Insulin Resistance: The Chicken and Egg Paradox - p. 375 5. Oxidative Stress: Overburning Fat - p. 378 6. Lipotoxicity: The Ugly and the Beast - p. 379 7. Endoplasmic Reticulum Stress: A Tree Born Crooked Cannot Straighten Its Trunk - p. 381 8. Autophagy: The Ouroboros Housekeeper - p. 383 9. Sterile Inflammation: When the Aggressor Is Fat - p. 383 10. Dysbiota: The Unwanted Guests - p. 385 11. Cell Death: A Cry for Help - p. 387 12. Fibrogenesis: To Heal or to Scar - p. 387 13. Conclusion - p. 389 14. References - p. 390 15. 26 Epidemiology, Natural History, and Evaluation of Nonalcoholic Fatty Liver Disease - p. 391 16. 27 Management of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome - p. 406 17. 28 Virology and Pathogenesis of Hepatitis C - p. 412 18. 29 Epidemiology, Natural History, and Diagnosis of Hepatitis C - p. 428 19. 30 Treatment of Hepatitis C - p. 446 20. 31 Virology and Pathogenesis of Hepatitis B - p. 464 21. 32 Epidemiology, Diagnosis, and Natural History of Hepatitis B - p. 474 22. 33 Treatment of Hepatitis B - p. 485 23. 34 Hepatitis D - p. 501 24. 35 Hepatitis A - p. 512 25. 36 Hepatitis E - p. 522 26. Section V Liver and Other Infections - p. 534.e4 27. 37 HIV and the Liver - p. 536 28. 38 Liver Disease Associated With Systemic Viral Infection - p. 556 29. 39 Parasitic Liver Disease - p. 568 30. 40 Bacterial and Miscellaneous Infections of the Liver - p. 579 31. Section VI Immune Diseases and the Liver - p. 592.e4 32. 41 Autoimmune Hepatitis - p. 594 33. 42 Primary Biliary Cholangitis - p. 610 34. 43 Primary and Secondary Sclerosing Cholangitis - p. 626 35. Section VII Vascular Diseases of the Liver - p. 647.e6 36. 44 Budd-Chiari Syndrome and Sinusoidal Obstruction Syndrome - p. 649 37. 45 Portal and Splenic Vein Thrombosis - p. 658 38. Section VIII Tumors of the Liver - p. 666.e3 39. 46 Hepatocellular Carcinoma - p. 668 40. Introduction - p. 668 41. Epidemiology - p. 668 42. Risk Factors - p. 669 43. Prevention - p. 673 44. Pathogenesis - p. 673 45. Hepatocellular Carcinoma Surveillance - p. 675 46. Viral Hepatitis - p. 675 47. Staging - p. 678 48. Pathology - p. 679 49. Histologic Variants - p. 680 50. Radiology - p. 681 51. Treatment - p. 682 52. Conclusion - p. 692 53. References - p. 692 54. 47 Cholangiocarcinoma - p. 693 55. 48 Other Malignant Hepatic Tumors - p. 708 56. 49 Benign Liver Tumors - p. 720 57. Section IX Liver Transplantation - p. 735.e4 58. 50 Pretransplant Evaluation and Care - p. 737 59. 51 Transplantation of the Liver - p. 753 60. 52 Post–Liver Transplant Management - p. 769 61. 53 Recurrent Primary Disease After Liver Transplantation - p. 784 62. Introduction - p. 784 63. Hepatitis B and Liver Transplantation - p. 784 64. Hepatitis C and Liver Transplantation - p. 794 65. Primary Biliary Cholangitis and Liver Transplantation - p. 806 66. Primary Sclerosing Cholangitis and Liver Transplantation - p. 808 67. Autoimmune Hepatitis and Liver Transplantation - p. 810 68. Nonalcoholic Fatty Liver and Liver Transplantation - p. 811 69. Alcoholic Liver Disease and Liver Transplantation - p. 813 70. Metabolic Liver Diseases and Liver Transplantation - p. 814 71. Conclusion - p. 815 72. References - p. 815 73. Section X Liver Affected by Other Conditions or Diseases - p. 815.e14 74. 54 The Liver in Pregnancy - p. 817 75. 55 Nutrition and the Liver - p. 837 76. 56 Drug-Induced Liver Injury - p. 844 77. Introduction - p. 844 78. Epidemiology, Common Causes, and Clinical Risk Factors - p. 846 79. Causality Assessment - p. 846 80. Mechanisms of Hepatic Injury Due to Drugs and Chemicals - p. 847 81. Immunologic Mechanisms of Drug-Induced Liver Injury - p. 852 82. Clinicopathologic Patterns of Drug-Induced Liver Injury - p. 853 83. Macrovesicular or Mixed Microvesicular and Macrovesicular Steatosis - p. 858 84. Predictable Versus Unpredictable Drug-Induced Liver Injury - p. 859 85. Drug-Induced Liver Injury Due To Specific Agents - p. 859 86. Liver Injury Due to Immune Checkpoint Inhibitors - p. 888 87. Botanicals, Herbal Products, and Dietary Supplements - p. 888 88. Conclusion - p. 889 89. Acknowledgments - p. 889 90. References - p. 889 91. 57 Preoperative and Postoperative Hepatic Dysfunctions - p. 891 92. Section XI Inherited and Pediatric Liver Diseases - p. 896.e2 93. 58 Bilirubin Metabolism and Its Disorders - p. 898 94. Introduction - p. 898 95. Jaundice as an Indicator of Hepatic Dysfunction - p. 898 96. Formation of Bilirubin - p. 898 97. Potential Beneficial Effects of Products of Heme Breakdown - p. 900 98. Measurement of Bilirubin Production - p. 900 99. Chemistry of Bilirubin - p. 901 100. Photochemistry of Bilirubin - p. 902 101. Bilirubin Toxicity - p. 902 102. Disposition of Bilirubin - p. 905 103. The Role of Albumin - p. 906 104. Hepatic Bilirubin Uptake - p. 907 105. Storage of Bilirubin Within the Hepatocyte - p. 909 106. Conjugation of Bilirubin - p. 909 107. Enzyme-Catalyzed Glucuronidation of Bilirubin - p. 909 108. Latency of Uridine Diphosphoglucuronate Glucuronosyltransferases - p. 909 109. Multiple Forms of Uridine Diphosphoglucuronate Glucuronosyltransferases - p. 909 110. Organization of the UGT1A Gene Family - p. 910 111. Bile Canalicular Secretion of Bilirubin Conjugates and Related Organic Anions - p. 911 112. Quantification of Bilirubin - p. 913 113. The Nature and Significance of Bilirubin in Body Fluids and Tissues - p. 914 114. Disorders of Bilirubin Metabolism - p. 915 115. Acknowledgments - p. 925 116. References - p. 925 117. 59 Wilson Disease - p. 926 118. 60 Hemochromatosis - p. 941 119. 61 α1-Antitrypsin Deficiency - p. 960 120. 62 Approach to and Evaluation of Metabolic Liver Diseases - p. 971 121. 63 Pediatric Cholestatic Syndromes - p. 976 122. 64 Fibrocystic Diseases of the Liver - p. 995 123. 65 Viral Hepatitis in Children - p. 1015 124. Index - p. 1029
Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout.
1. Introduction - p. 369 2. Making Foie Gras - p. 371 3. Nonalcoholic Fatty Liver Disease: An Adiposopathy - p. 374 4. Nonalcoholic Fatty Liver Disease and Insulin Resistance: The Chicken and Egg Paradox - p. 375 5. Oxidative Stress: Overburning Fat - p. 378 6. Lipotoxicity: The Ugly and the Beast - p. 379 7. Endoplasmic Reticulum Stress: A Tree Born Crooked Cannot Straighten Its Trunk - p. 381 8. Autophagy: The Ouroboros Housekeeper - p. 383 9. Sterile Inflammation: When the Aggressor Is Fat - p. 383 10. Dysbiota: The Unwanted Guests - p. 385 11. Cell Death: A Cry for Help - p. 387 12. Fibrogenesis: To Heal or to Scar - p. 387 13. Conclusion - p. 389 14. References - p. 390 15. 26 Epidemiology, Natural History, and Evaluation of Nonalcoholic Fatty Liver Disease - p. 391 16. 27 Management of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome - p. 406 17. 28 Virology and Pathogenesis of Hepatitis C - p. 412 18. 29 Epidemiology, Natural History, and Diagnosis of Hepatitis C - p. 428 19. 30 Treatment of Hepatitis C - p. 446 20. 31 Virology and Pathogenesis of Hepatitis B - p. 464 21. 32 Epidemiology, Diagnosis, and Natural History of Hepatitis B - p. 474 22. 33 Treatment of Hepatitis B - p. 485 23. 34 Hepatitis D - p. 501 24. 35 Hepatitis A - p. 512 25. 36 Hepatitis E - p. 522 26. Section V Liver and Other Infections - p. 534.e4 27. 37 HIV and the Liver - p. 536 28. 38 Liver Disease Associated With Systemic Viral Infection - p. 556 29. 39 Parasitic Liver Disease - p. 568 30. 40 Bacterial and Miscellaneous Infections of the Liver - p. 579 31. Section VI Immune Diseases and the Liver - p. 592.e4 32. 41 Autoimmune Hepatitis - p. 594 33. 42 Primary Biliary Cholangitis - p. 610 34. 43 Primary and Secondary Sclerosing Cholangitis - p. 626 35. Section VII Vascular Diseases of the Liver - p. 647.e6 36. 44 Budd-Chiari Syndrome and Sinusoidal Obstruction Syndrome - p. 649 37. 45 Portal and Splenic Vein Thrombosis - p. 658 38. Section VIII Tumors of the Liver - p. 666.e3 39. 46 Hepatocellular Carcinoma - p. 668 40. Introduction - p. 668 41. Epidemiology - p. 668 42. Risk Factors - p. 669 43. Prevention - p. 673 44. Pathogenesis - p. 673 45. Hepatocellular Carcinoma Surveillance - p. 675 46. Viral Hepatitis - p. 675 47. Staging - p. 678 48. Pathology - p. 679 49. Histologic Variants - p. 680 50. Radiology - p. 681 51. Treatment - p. 682 52. Conclusion - p. 692 53. References - p. 692 54. 47 Cholangiocarcinoma - p. 693 55. 48 Other Malignant Hepatic Tumors - p. 708 56. 49 Benign Liver Tumors - p. 720 57. Section IX Liver Transplantation - p. 735.e4 58. 50 Pretransplant Evaluation and Care - p. 737 59. 51 Transplantation of the Liver - p. 753 60. 52 Post–Liver Transplant Management - p. 769 61. 53 Recurrent Primary Disease After Liver Transplantation - p. 784 62. Introduction - p. 784 63. Hepatitis B and Liver Transplantation - p. 784 64. Hepatitis C and Liver Transplantation - p. 794 65. Primary Biliary Cholangitis and Liver Transplantation - p. 806 66. Primary Sclerosing Cholangitis and Liver Transplantation - p. 808 67. Autoimmune Hepatitis and Liver Transplantation - p. 810 68. Nonalcoholic Fatty Liver and Liver Transplantation - p. 811 69. Alcoholic Liver Disease and Liver Transplantation - p. 813 70. Metabolic Liver Diseases and Liver Transplantation - p. 814 71. Conclusion - p. 815 72. References - p. 815 73. Section X Liver Affected by Other Conditions or Diseases - p. 815.e14 74. 54 The Liver in Pregnancy - p. 817 75. 55 Nutrition and the Liver - p. 837 76. 56 Drug-Induced Liver Injury - p. 844 77. Introduction - p. 844 78. Epidemiology, Common Causes, and Clinical Risk Factors - p. 846 79. Causality Assessment - p. 846 80. Mechanisms of Hepatic Injury Due to Drugs and Chemicals - p. 847 81. Immunologic Mechanisms of Drug-Induced Liver Injury - p. 852 82. Clinicopathologic Patterns of Drug-Induced Liver Injury - p. 853 83. Macrovesicular or Mixed Microvesicular and Macrovesicular Steatosis - p. 858 84. Predictable Versus Unpredictable Drug-Induced Liver Injury - p. 859 85. Drug-Induced Liver Injury Due To Specific Agents - p. 859 86. Liver Injury Due to Immune Checkpoint Inhibitors - p. 888 87. Botanicals, Herbal Products, and Dietary Supplements - p. 888 88. Conclusion - p. 889 89. Acknowledgments - p. 889 90. References - p. 889 91. 57 Preoperative and Postoperative Hepatic Dysfunctions - p. 891 92. Section XI Inherited and Pediatric Liver Diseases - p. 896.e2 93. 58 Bilirubin Metabolism and Its Disorders - p. 898 94. Introduction - p. 898 95. Jaundice as an Indicator of Hepatic Dysfunction - p. 898 96. Formation of Bilirubin - p. 898 97. Potential Beneficial Effects of Products of Heme Breakdown - p. 900 98. Measurement of Bilirubin Production - p. 900 99. Chemistry of Bilirubin - p. 901 100. Photochemistry of Bilirubin - p. 902 101. Bilirubin Toxicity - p. 902 102. Disposition of Bilirubin - p. 905 103. The Role of Albumin - p. 906 104. Hepatic Bilirubin Uptake - p. 907 105. Storage of Bilirubin Within the Hepatocyte - p. 909 106. Conjugation of Bilirubin - p. 909 107. Enzyme-Catalyzed Glucuronidation of Bilirubin - p. 909 108. Latency of Uridine Diphosphoglucuronate Glucuronosyltransferases - p. 909 109. Multiple Forms of Uridine Diphosphoglucuronate Glucuronosyltransferases - p. 909 110. Organization of the UGT1A Gene Family - p. 910 111. Bile Canalicular Secretion of Bilirubin Conjugates and Related Organic Anions - p. 911 112. Quantification of Bilirubin - p. 913 113. The Nature and Significance of Bilirubin in Body Fluids and Tissues - p. 914 114. Disorders of Bilirubin Metabolism - p. 915 115. Acknowledgments - p. 925 116. References - p. 925 117. 59 Wilson Disease - p. 926 118. 60 Hemochromatosis - p. 941 119. 61 α1-Antitrypsin Deficiency - p. 960 120. 62 Approach to and Evaluation of Metabolic Liver Diseases - p. 971 121. 63 Pediatric Cholestatic Syndromes - p. 976 122. 64 Fibrocystic Diseases of the Liver - p. 995 123. 65 Viral Hepatitis in Children - p. 1015 124. Index - p. 1029
