Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.
Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.
1. Advances in Prodrugs - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. Editors biography - p. Page vii 8. List of Illustrations - p. Page viii 9. List of Tables - p. Page ix 10. Chapter 1 : Prodrugs: General concepts and prodrug design in medicinal chemistry - p. Page ix 11. Chapter 2 : pH-sensitive prodrugs - p. Page 17 12. Chapter 3 : Enzyme-mediated activation of prodrugs - p. Page 36 13. Chapter 4 : Reactive oxygen species-responsive prodrugs - p. Page 50 14. Chapter 5 : Photoactivatable prodrugs - p. Page 67 15. Chapter 6 : Antibody-directed enzyme prodrug therapy (ADEPT) - p. Page 92 16. Chapter 7 : Self-assembling prodrugs - p. Page 107 17. Chapter 8 : Prodrug-based nanomedicines: A successful rationale to design novel and effective delivery strategies - p. Page 144 18. Chapter 9 : Hypoxia-activated prodrugs - p. Page 167 19. Chapter 10 : Antiviral and antiretroviral prodrugs - p. Page 200 20. Chapter 11 : Prodrugs for cancer therapy - p. Page 229 21. Chapter 12 : Prodrugs for neurodegenerative diseases - p. Page 256 22. Chapter 13 : Prodrugs in cardiovascular therapy - p. Page 280 23. Chapter 14 : Prodrugs for ocular diseases - p. Page 302 24. Chapter 15 : Antibacterial prodrugs - p. Page 313 25. Chapter 16 : Prodrugs on neglected tropical diseases and therapeutic advances - p. Page 326 26. Index - p. Page 351
Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.
Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.
1. Advances in Prodrugs - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. Editors biography - p. Page vii 8. List of Illustrations - p. Page viii 9. List of Tables - p. Page ix 10. Chapter 1 : Prodrugs: General concepts and prodrug design in medicinal chemistry - p. Page ix 11. Chapter 2 : pH-sensitive prodrugs - p. Page 17 12. Chapter 3 : Enzyme-mediated activation of prodrugs - p. Page 36 13. Chapter 4 : Reactive oxygen species-responsive prodrugs - p. Page 50 14. Chapter 5 : Photoactivatable prodrugs - p. Page 67 15. Chapter 6 : Antibody-directed enzyme prodrug therapy (ADEPT) - p. Page 92 16. Chapter 7 : Self-assembling prodrugs - p. Page 107 17. Chapter 8 : Prodrug-based nanomedicines: A successful rationale to design novel and effective delivery strategies - p. Page 144 18. Chapter 9 : Hypoxia-activated prodrugs - p. Page 167 19. Chapter 10 : Antiviral and antiretroviral prodrugs - p. Page 200 20. Chapter 11 : Prodrugs for cancer therapy - p. Page 229 21. Chapter 12 : Prodrugs for neurodegenerative diseases - p. Page 256 22. Chapter 13 : Prodrugs in cardiovascular therapy - p. Page 280 23. Chapter 14 : Prodrugs for ocular diseases - p. Page 302 24. Chapter 15 : Antibacterial prodrugs - p. Page 313 25. Chapter 16 : Prodrugs on neglected tropical diseases and therapeutic advances - p. Page 326 26. Index - p. Page 351
