Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xvii 7. Preface - p. xxiii 8. Part I: Introductory chapters: Setting the scene for the neuroscience of aging - p. xxiv 9. Chapter 1. The concept of productive aging - p. 3 10. Chapter 2. Quality of life in older people - p. 13 11. Chapter 3. Successful aging and diet - p. 21 12. Chapter 4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective - p. 29 13. Chapter 5. The brain in life span: use of phase functional magnetic resonance imaging - p. 39 14. Chapter 6. Neuronal structure in aging: cytoskeleton in health and disease - p. 53 15. Chapter 7. Sporadic Alzheimer’s triad: age, sex, and ApoE - p. 65 16. Chapter 8. The moderating effect of BDNF Val66Met polymorphism on inhibitory control in elderly individuals - p. 79 17. Chapter 9. Alcohol use disorder pharmacotherapy options for postmenopausal females: age and gender issues and considerations - p. 91 18. Chapter 10. The aging brain and brain banking - p. 103 19. Part II: Impairments and diseases - p. 112 20. Chapter 11. Dementia or no dementia in the elderly. Why? - p. 115 21. Chapter 12. Neuropsychology, social cognition, and loss of insight in frontotemporal dementia - p. 127 22. Chapter 13. Neuroinflammation and aging - p. 139 23. Chapter 14. Cortical microinfarcts and the aging brain - p. 153 24. Chapter 15. Cerebrovascular and neurodegenerative racial/ethnic health disparities - p. 163 25. Chapter 16. Hearing loss among the elderly - p. 173 26. Chapter 17. Aging auditory cortex: the impact of reduced inhibition on function - p. 183 27. Chapter 18. Aging and vestibular disorders - p. 193 28. Chapter 19. Brain aging in HIV and retrovirals - p. 203 29. Chapter 20. Methylmercury exposure and its implications for aging - p. 213 30. Chapter 21. Alcohol and the aging brain: increased alcohol sensitivity potentially magnifying oxidative stress - p. 225 31. Part III: Biomarkers and diagnosis - p. 232 32. Chapter 22. Brain aging: radiological biomarkers - p. 235 33. Chapter 23. ADAM10 as a biomarker for Alzheimer’s disease - p. 249 34. Chapter 24. Circulating microRNAs as biomarkers of health in elderly individuals - p. 259 35. Chapter 25. DHEA as a biomarker of aging in humans and nonhuman primates: synthesis, neuroprotection, and cognitive function - p. 269 36. Chapter 26. Evaluation of subjective memory abilities in elderly people - p. 279 37. Chapter 27. The functional activities questionnaire: applications to aging - p. 293 38. Chapter 28. Autobiographical memory as a diagnostic tool in aging - p. 305 39. Chapter 29. Assessment tools for subjective memory abilities in elderly people - p. 315 40. Chapter 30. The Knowledge of Memory Aging Questionnaire - p. 329 41. Part IV: Management and treatments - p. 339 42. Chapter 31. Pharmacological use of transient receptor potential (TRP) ion channel agonists in neurological disease and aging: effects on swallowing and implications for nutrition - p. 343 43. Chapter 32. Aripiprazole: features and use in the aged - p. 355 44. Chapter 33. Cognition-enhancing drugs and applications to aging - p. 367 45. Chapter 34. Creatine supplementation in the aging brain - p. 379 46. Chapter 35. Photobiomodulation as a brain-boosting strategy in aging - p. 389 47. Chapter 36. Innovations in deep brain stimulation in aging: a focus on Parkinson disease - p. 403 48. Chapter 37. Exergames: what they are and how they can be used to successful aging? - p. 415 49. Chapter 38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly - p. 425 50. Chapter 39. Training the functionality of daily life. A new neuroscientific paradigm of cognitive training - p. 439 51. Chapter 40. Integrated medical and psychiatric self-management smartphone technologies for older adults with serious mental illness - p. 447 52. Chapter 41. Psychosocial interventions for suicide prevention in the elderly: advances and future directions - p. 459 53. Part V: Models and modelling - p. 468 54. D-galactose-induced aging and brain mitochondria - p. 471 55. Drosophila models of neuronal aging - p. 481 56. The zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging - p. 491 57. Chapter 45. Murine models of tauopathies: a platform to study neurodegenerative diseases associated with aging - p. 505 58. Chapter 46. Modeling nutrition and brain aging in rodents - p. 517 59. Chapter 47. Nonhuman primates as models for aging and Alzheimer’s disease - p. 527 60. Chapter 48. Linking aging and animal models to neurodegeneration: the striatum, substantia nigra, and Parkinson’s disease - p. 539 61. Chapter 49. Behavioral evaluation of aging in experimental animals - p. 553 62. Part VI: Resources - p. 564 63. Chapter 50. Recommended resources on the neuroscience of aging - p. 567 64. Index - p. 575
Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. xvii 7. Preface - p. xxiii 8. Part I: Introductory chapters: Setting the scene for the neuroscience of aging - p. xxiv 9. Chapter 1. The concept of productive aging - p. 3 10. Chapter 2. Quality of life in older people - p. 13 11. Chapter 3. Successful aging and diet - p. 21 12. Chapter 4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective - p. 29 13. Chapter 5. The brain in life span: use of phase functional magnetic resonance imaging - p. 39 14. Chapter 6. Neuronal structure in aging: cytoskeleton in health and disease - p. 53 15. Chapter 7. Sporadic Alzheimer’s triad: age, sex, and ApoE - p. 65 16. Chapter 8. The moderating effect of BDNF Val66Met polymorphism on inhibitory control in elderly individuals - p. 79 17. Chapter 9. Alcohol use disorder pharmacotherapy options for postmenopausal females: age and gender issues and considerations - p. 91 18. Chapter 10. The aging brain and brain banking - p. 103 19. Part II: Impairments and diseases - p. 112 20. Chapter 11. Dementia or no dementia in the elderly. Why? - p. 115 21. Chapter 12. Neuropsychology, social cognition, and loss of insight in frontotemporal dementia - p. 127 22. Chapter 13. Neuroinflammation and aging - p. 139 23. Chapter 14. Cortical microinfarcts and the aging brain - p. 153 24. Chapter 15. Cerebrovascular and neurodegenerative racial/ethnic health disparities - p. 163 25. Chapter 16. Hearing loss among the elderly - p. 173 26. Chapter 17. Aging auditory cortex: the impact of reduced inhibition on function - p. 183 27. Chapter 18. Aging and vestibular disorders - p. 193 28. Chapter 19. Brain aging in HIV and retrovirals - p. 203 29. Chapter 20. Methylmercury exposure and its implications for aging - p. 213 30. Chapter 21. Alcohol and the aging brain: increased alcohol sensitivity potentially magnifying oxidative stress - p. 225 31. Part III: Biomarkers and diagnosis - p. 232 32. Chapter 22. Brain aging: radiological biomarkers - p. 235 33. Chapter 23. ADAM10 as a biomarker for Alzheimer’s disease - p. 249 34. Chapter 24. Circulating microRNAs as biomarkers of health in elderly individuals - p. 259 35. Chapter 25. DHEA as a biomarker of aging in humans and nonhuman primates: synthesis, neuroprotection, and cognitive function - p. 269 36. Chapter 26. Evaluation of subjective memory abilities in elderly people - p. 279 37. Chapter 27. The functional activities questionnaire: applications to aging - p. 293 38. Chapter 28. Autobiographical memory as a diagnostic tool in aging - p. 305 39. Chapter 29. Assessment tools for subjective memory abilities in elderly people - p. 315 40. Chapter 30. The Knowledge of Memory Aging Questionnaire - p. 329 41. Part IV: Management and treatments - p. 339 42. Chapter 31. Pharmacological use of transient receptor potential (TRP) ion channel agonists in neurological disease and aging: effects on swallowing and implications for nutrition - p. 343 43. Chapter 32. Aripiprazole: features and use in the aged - p. 355 44. Chapter 33. Cognition-enhancing drugs and applications to aging - p. 367 45. Chapter 34. Creatine supplementation in the aging brain - p. 379 46. Chapter 35. Photobiomodulation as a brain-boosting strategy in aging - p. 389 47. Chapter 36. Innovations in deep brain stimulation in aging: a focus on Parkinson disease - p. 403 48. Chapter 37. Exergames: what they are and how they can be used to successful aging? - p. 415 49. Chapter 38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly - p. 425 50. Chapter 39. Training the functionality of daily life. A new neuroscientific paradigm of cognitive training - p. 439 51. Chapter 40. Integrated medical and psychiatric self-management smartphone technologies for older adults with serious mental illness - p. 447 52. Chapter 41. Psychosocial interventions for suicide prevention in the elderly: advances and future directions - p. 459 53. Part V: Models and modelling - p. 468 54. D-galactose-induced aging and brain mitochondria - p. 471 55. Drosophila models of neuronal aging - p. 481 56. The zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging - p. 491 57. Chapter 45. Murine models of tauopathies: a platform to study neurodegenerative diseases associated with aging - p. 505 58. Chapter 46. Modeling nutrition and brain aging in rodents - p. 517 59. Chapter 47. Nonhuman primates as models for aging and Alzheimer’s disease - p. 527 60. Chapter 48. Linking aging and animal models to neurodegeneration: the striatum, substantia nigra, and Parkinson’s disease - p. 539 61. Chapter 49. Behavioral evaluation of aging in experimental animals - p. 553 62. Part VI: Resources - p. 564 63. Chapter 50. Recommended resources on the neuroscience of aging - p. 567 64. Index - p. 575
