Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target.
Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.
1. Chapter 1 : Introduction - p. Page xii 2. Chapter 2 : Mechanisms of autophagy: the machinery of macroautophagy and points of control - p. Page 7 3. Chapter 3 : Regulation of autophagy—transcriptional, posttranscriptional, translational, and posttranslational mechanisms - p. Page 16 4. Chapter 4 : Selectivity and trafficking of autophagic cargoes - p. Page 34 5. Chapter 5 : The role of lysosomes in autophagy - p. Page 51 6. Chapter 6 : Methods for measuring autophagy - p. Page 66 7. Chapter 7 : Effects of physiologic inputs on autophagy - p. Page 77 8. Chapter 8 : Autophagy in germ cells, stem cells, and induced pluripotent stem cells - p. Page 90 9. Chapter 9 : Role of autophagy in embryogenesis - p. Page 108 10. Chapter 10 : Autophagy in hematopoiesis and leukemogenesis - p. Page 121 11. Chapter 11 : Autophagy in cell plasticity with particular focus on paligenosis - p. Page 138 12. Chapter 12 : Autophagy in the liver - p. Page 153 13. Chapter 13 : Autophagy in adipose tissue - p. Page 171 14. Chapter 14 : Autophagy in the pancreas - p. Page 191 15. Chapter 15 : Skeletal muscle - p. Page 209 16. Chapter 16 : Autophagy in the cardiovascular system - p. Page 221 17. Chapter 17 : Lungs - p. Page 238 18. Chapter 18 : Autophagy in the vasculature - p. Page 254 19. Chapter 19 : Altered autophagy on the path to Parkinson's disease - p. Page 266 20. Chapter 20 : Autophagic processes in early- and late-onset Alzheimer's disease - p. Page 282 21. Chapter 21 : Autophagy as an integral immune system component - p. Page 296 22. Chapter 22 : Autophagy in the gastrointestinal system and cross talk with microbiota - p. Page 318 23. Chapter 23 : Role of autophagy in building and maintaining the skeletal system - p. Page 330 24. Chapter 24 : Autophagy on the road to longevity and aging - p. Page 342 25. Chapter 25 : Autophagy in cancer: friend or foe? - p. Page 357 26. Chapter 26 : Mammalian microautophagy: mechanism and roles in disease - p. Page 376 27. Chapter 27 : Chaperone-mediated autophagy—mechanisms and disease role - p. Page 394 28. Chapter 28 : Targeting autophagy: lifestyle and pharmacological approaches - p. Page 409 29. Index - p. Page 423
Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target.
Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.
1. Chapter 1 : Introduction - p. Page xii 2. Chapter 2 : Mechanisms of autophagy: the machinery of macroautophagy and points of control - p. Page 7 3. Chapter 3 : Regulation of autophagy—transcriptional, posttranscriptional, translational, and posttranslational mechanisms - p. Page 16 4. Chapter 4 : Selectivity and trafficking of autophagic cargoes - p. Page 34 5. Chapter 5 : The role of lysosomes in autophagy - p. Page 51 6. Chapter 6 : Methods for measuring autophagy - p. Page 66 7. Chapter 7 : Effects of physiologic inputs on autophagy - p. Page 77 8. Chapter 8 : Autophagy in germ cells, stem cells, and induced pluripotent stem cells - p. Page 90 9. Chapter 9 : Role of autophagy in embryogenesis - p. Page 108 10. Chapter 10 : Autophagy in hematopoiesis and leukemogenesis - p. Page 121 11. Chapter 11 : Autophagy in cell plasticity with particular focus on paligenosis - p. Page 138 12. Chapter 12 : Autophagy in the liver - p. Page 153 13. Chapter 13 : Autophagy in adipose tissue - p. Page 171 14. Chapter 14 : Autophagy in the pancreas - p. Page 191 15. Chapter 15 : Skeletal muscle - p. Page 209 16. Chapter 16 : Autophagy in the cardiovascular system - p. Page 221 17. Chapter 17 : Lungs - p. Page 238 18. Chapter 18 : Autophagy in the vasculature - p. Page 254 19. Chapter 19 : Altered autophagy on the path to Parkinson's disease - p. Page 266 20. Chapter 20 : Autophagic processes in early- and late-onset Alzheimer's disease - p. Page 282 21. Chapter 21 : Autophagy as an integral immune system component - p. Page 296 22. Chapter 22 : Autophagy in the gastrointestinal system and cross talk with microbiota - p. Page 318 23. Chapter 23 : Role of autophagy in building and maintaining the skeletal system - p. Page 330 24. Chapter 24 : Autophagy on the road to longevity and aging - p. Page 342 25. Chapter 25 : Autophagy in cancer: friend or foe? - p. Page 357 26. Chapter 26 : Mammalian microautophagy: mechanism and roles in disease - p. Page 376 27. Chapter 27 : Chaperone-mediated autophagy—mechanisms and disease role - p. Page 394 28. Chapter 28 : Targeting autophagy: lifestyle and pharmacological approaches - p. Page 409 29. Index - p. Page 423
