1. Cover image - p. i 2. Title page - p. ii 3. Copyright - p. iv 4. Preface - p. iv 5. Contributors - p. vi 6. Contents - p. v 7. 1 Maximizing Test Performance - p. 1 8. Section 1 Respiratory - p. 5 9. 2 Respiratory Embryology and Physiology - p. 6 10. 3 Respiratory Distress Syndrome, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia - p. 19 11. 4 Aspiration, Pneumonia, and Persistent Pulmonary Hypertension - p. 25 12. 5 Pleural Disorders and Additional Causes of Respiratory Distress - p. 29 13. 6 Apnea of Prematurity and Neonatal Respiratory Depression - p. 35 14. 7 Assisted Ventilation, ECMO, and Pharmacologic Agents - p. 39 15. SECTION 2 Cardiovascular - p. 45 16. 8 Cardiac Development - p. 46 17. 9 Cardiovascular Physiology - p. 52 18. 10 Presentation of Congenital Heart Disease - p. 55 19. 11 Cardiopulmonary Dysfunction - p. 70 20. 12 Electrocardiography, Electrophysiology, and Dysrhythmias - p. 75 21. 13 Pharmacologic Therapy of Heart Disease - p. 81 22. SECTION 3 Neurology and Neurodevelopment - p. 85 23. 14 Neurologic Evaluation - p. 86 24. 15 Development of the Nervous System - p. 88 25. 16 Neonatal Encephalopathy - p. 93 26. 17 Intracranial Hemorrhageand Vascular Injury - p. 96 27. 18 Neonatal Neurology Cranial and Neurologic Trauma - p. 100 28. 19 Neonatal Seizures - p. 104 29. 20 Central Nervous System Infections - p. 107 30. 21 Neonatal Abstinence Syndromes and Substance Exposure In Utero - p. 109 31. 22 Hypotonia and Other Aspects - p. 111 32. 23 Neurodevelopmental Impairments - p. 115 33. 24 Causes and Effects of Environment on Neurodevelopmental Impairment - p. 119 34. 25 Clinical Features of Neurodevelopmental Impairment - p. 123 35. SECTION 4 Immunology and Infectious Diseases - p. 127 36. 26 Development of the Immune System - p. 128 37. 27 Components of the Immune System - p. 131 38. 28 Abnormal Immune System Development - p. 136 39. 29 Infections of Organ Systems - p. 141 40. 30 Causative Agents of Infections - p. 150 41. 31 Prevention of Infections and Immunization - p. 164 42. SECTION 5 Nutrition - p. 171 43. 32 Nutrition and Growth - p. 172 44. 33 Minerals, Vitamins, and Trace Minerals - p. 179 45. 34 Enteral Nutrition - p. 183 46. 35 Parenteral Nutrition - p. 190 47. SECTION 6 Gastroenterology and Bilirubin - p. 195 48. 36 Gastrointestinal Development - p. 196 49. 37 Gastrointestinal Anomalies - p. 199 50. 38 Acquired Disorders of Gastrointestinal Tract - p. 206 51. 39 Liver Disease, Abdominal Masses, and Ascites in the Newborn - p. 210 52. 40 Bilirubin Biochemistry Metabolism and Measurement - p. 213 53. 41 Bilirubin Toxicity - p. 215 54. 42 Physiologic and Breast Milk Jaundice - p. 218 55. SECTION 7 Maternal-Fetal Medicine - p. 221 56. 43 Pregnancy - p. 222 57. 44 Fetal Assessment and Treatment - p. 234 58. 45 Labor and Delivery - p. 238 59. SECTION 8 Resuscitation and Stabilization - p. 241 60. 46 Resuscitation, Stabilization, and Asphyxia - p. 242 61. SECTION 9 Genetics and Dysmorphism - p. 249 62. 47 Molecular Genetics - p. 250 63. 48 Patterns of Congenital Disorders - p. 255 64. 49 Nongenetic Etiologies for Congenital Defects - p. 263 65. 50 Evaluation of Infants With Congenital Anomalies - p. 266 66. 51 Inborn Errors of Metabolism - p. 271 67. SECTION 10 Water, Salt, Renal - p. 279 68. 52 Water/Electrolyte Metabolism and Acid–Base Balance - p. 280 69. 53 Abnormal Renal Development - p. 293 70. SECTION 11 Endocrine, Metabolic, Thermal - p. 301 71. 54 Normal and Abnormal Sexual Differentiation - p. 302 72. 55 Adrenal Disorders - p. 307 73. 56 Thyroid Disorders - p. 311 74. 57 Glucose Metabolism - p. 315 75. 58 Calcium, Phosphorus, and Magnesium Metabolism - p. 319 76. 59 Thermoregulation - p. 325 77. SECTION 12 Hematology and Oncology - p. 327 78. 60 Erythrocytes - p. 328 79. 61 White Blood Cells - p. 336 80. 62 Platelets and Coagulation - p. 339 81. 63 Transfusion Therapy in Neonates - p. 345 82. 64 Solid Tumors and Leukemias - p. 348 83. SECTION 13 Head (Ears, Eyes, Nose, Throat), Neck, and Skin - p. 355 84. 65 Eye Development, Retinopathy of Prematurity - p. 356 85. 66 Ear Development and Anomalies - p. 361 86. 67 Nose, Mouth, and Throat Development and Anomalies - p. 365 87. 68 Skin Development and Function - p. 371 88. 69 Neonatal Skin Lesions - p. 373 89. SECTION 14 Surgical and Complex NICU Patient Management - p. 389 90. 70 Neonatal Surgical Management - p. 390 91. 71 Complex Neonatal Patient Management - p. 397 92. SECTION 15 Basic Pharmacology Principles - p. 405 93. 72 Drug Disposition and Pharmacokinetics - p. 406 94. 73 Clinical Toxicology - p. 413 95. 74 Indications, Mechanisms, and Adverse Reactions for Common Drugs - p. 416 96. SECTION 16 Management of Neonatal Care Systems - p. 419 97. 75 Organization of Perinatal Care - p. 420 98. 76 Ethical and Legal Issues in Neonatology - p. 424 99. SECTION 17 Scholarly Activities and Quality Improvement - p. 427 100. 77 Biostatistics in Research - p. 428 101. 78 Epidemiology and Clinical Research Design - p. 435 102. 79 Applying Research to Clinical Practice - p. 441 103. 80 Quality Improvement - p. 446 104. 81 Principles of Teaching and Learning - p. 451 105. 82 Ethics in Research - p. 455 106. SECTION 18 Diagnostic Imaging - p. 459 107. 83 Neurologic Imaging - p. 460 108. 84 Chest Imaging - p. 469 109. 85 Abdominal Imaging - p. 476 110. 86 Miscellaneous Imaging - p. 481 111. Questions Section - p. 486 112. Index - p. 563
1. Cover image - p. i 2. Title page - p. ii 3. Copyright - p. iv 4. Preface - p. iv 5. Contributors - p. vi 6. Contents - p. v 7. 1 Maximizing Test Performance - p. 1 8. Section 1 Respiratory - p. 5 9. 2 Respiratory Embryology and Physiology - p. 6 10. 3 Respiratory Distress Syndrome, Transient Tachypnea of the Newborn, and Bronchopulmonary Dysplasia - p. 19 11. 4 Aspiration, Pneumonia, and Persistent Pulmonary Hypertension - p. 25 12. 5 Pleural Disorders and Additional Causes of Respiratory Distress - p. 29 13. 6 Apnea of Prematurity and Neonatal Respiratory Depression - p. 35 14. 7 Assisted Ventilation, ECMO, and Pharmacologic Agents - p. 39 15. SECTION 2 Cardiovascular - p. 45 16. 8 Cardiac Development - p. 46 17. 9 Cardiovascular Physiology - p. 52 18. 10 Presentation of Congenital Heart Disease - p. 55 19. 11 Cardiopulmonary Dysfunction - p. 70 20. 12 Electrocardiography, Electrophysiology, and Dysrhythmias - p. 75 21. 13 Pharmacologic Therapy of Heart Disease - p. 81 22. SECTION 3 Neurology and Neurodevelopment - p. 85 23. 14 Neurologic Evaluation - p. 86 24. 15 Development of the Nervous System - p. 88 25. 16 Neonatal Encephalopathy - p. 93 26. 17 Intracranial Hemorrhageand Vascular Injury - p. 96 27. 18 Neonatal Neurology Cranial and Neurologic Trauma - p. 100 28. 19 Neonatal Seizures - p. 104 29. 20 Central Nervous System Infections - p. 107 30. 21 Neonatal Abstinence Syndromes and Substance Exposure In Utero - p. 109 31. 22 Hypotonia and Other Aspects - p. 111 32. 23 Neurodevelopmental Impairments - p. 115 33. 24 Causes and Effects of Environment on Neurodevelopmental Impairment - p. 119 34. 25 Clinical Features of Neurodevelopmental Impairment - p. 123 35. SECTION 4 Immunology and Infectious Diseases - p. 127 36. 26 Development of the Immune System - p. 128 37. 27 Components of the Immune System - p. 131 38. 28 Abnormal Immune System Development - p. 136 39. 29 Infections of Organ Systems - p. 141 40. 30 Causative Agents of Infections - p. 150 41. 31 Prevention of Infections and Immunization - p. 164 42. SECTION 5 Nutrition - p. 171 43. 32 Nutrition and Growth - p. 172 44. 33 Minerals, Vitamins, and Trace Minerals - p. 179 45. 34 Enteral Nutrition - p. 183 46. 35 Parenteral Nutrition - p. 190 47. SECTION 6 Gastroenterology and Bilirubin - p. 195 48. 36 Gastrointestinal Development - p. 196 49. 37 Gastrointestinal Anomalies - p. 199 50. 38 Acquired Disorders of Gastrointestinal Tract - p. 206 51. 39 Liver Disease, Abdominal Masses, and Ascites in the Newborn - p. 210 52. 40 Bilirubin Biochemistry Metabolism and Measurement - p. 213 53. 41 Bilirubin Toxicity - p. 215 54. 42 Physiologic and Breast Milk Jaundice - p. 218 55. SECTION 7 Maternal-Fetal Medicine - p. 221 56. 43 Pregnancy - p. 222 57. 44 Fetal Assessment and Treatment - p. 234 58. 45 Labor and Delivery - p. 238 59. SECTION 8 Resuscitation and Stabilization - p. 241 60. 46 Resuscitation, Stabilization, and Asphyxia - p. 242 61. SECTION 9 Genetics and Dysmorphism - p. 249 62. 47 Molecular Genetics - p. 250 63. 48 Patterns of Congenital Disorders - p. 255 64. 49 Nongenetic Etiologies for Congenital Defects - p. 263 65. 50 Evaluation of Infants With Congenital Anomalies - p. 266 66. 51 Inborn Errors of Metabolism - p. 271 67. SECTION 10 Water, Salt, Renal - p. 279 68. 52 Water/Electrolyte Metabolism and Acid–Base Balance - p. 280 69. 53 Abnormal Renal Development - p. 293 70. SECTION 11 Endocrine, Metabolic, Thermal - p. 301 71. 54 Normal and Abnormal Sexual Differentiation - p. 302 72. 55 Adrenal Disorders - p. 307 73. 56 Thyroid Disorders - p. 311 74. 57 Glucose Metabolism - p. 315 75. 58 Calcium, Phosphorus, and Magnesium Metabolism - p. 319 76. 59 Thermoregulation - p. 325 77. SECTION 12 Hematology and Oncology - p. 327 78. 60 Erythrocytes - p. 328 79. 61 White Blood Cells - p. 336 80. 62 Platelets and Coagulation - p. 339 81. 63 Transfusion Therapy in Neonates - p. 345 82. 64 Solid Tumors and Leukemias - p. 348 83. SECTION 13 Head (Ears, Eyes, Nose, Throat), Neck, and Skin - p. 355 84. 65 Eye Development, Retinopathy of Prematurity - p. 356 85. 66 Ear Development and Anomalies - p. 361 86. 67 Nose, Mouth, and Throat Development and Anomalies - p. 365 87. 68 Skin Development and Function - p. 371 88. 69 Neonatal Skin Lesions - p. 373 89. SECTION 14 Surgical and Complex NICU Patient Management - p. 389 90. 70 Neonatal Surgical Management - p. 390 91. 71 Complex Neonatal Patient Management - p. 397 92. SECTION 15 Basic Pharmacology Principles - p. 405 93. 72 Drug Disposition and Pharmacokinetics - p. 406 94. 73 Clinical Toxicology - p. 413 95. 74 Indications, Mechanisms, and Adverse Reactions for Common Drugs - p. 416 96. SECTION 16 Management of Neonatal Care Systems - p. 419 97. 75 Organization of Perinatal Care - p. 420 98. 76 Ethical and Legal Issues in Neonatology - p. 424 99. SECTION 17 Scholarly Activities and Quality Improvement - p. 427 100. 77 Biostatistics in Research - p. 428 101. 78 Epidemiology and Clinical Research Design - p. 435 102. 79 Applying Research to Clinical Practice - p. 441 103. 80 Quality Improvement - p. 446 104. 81 Principles of Teaching and Learning - p. 451 105. 82 Ethics in Research - p. 455 106. SECTION 18 Diagnostic Imaging - p. 459 107. 83 Neurologic Imaging - p. 460 108. 84 Chest Imaging - p. 469 109. 85 Abdominal Imaging - p. 476 110. 86 Miscellaneous Imaging - p. 481 111. Questions Section - p. 486 112. Index - p. 563
