Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.
Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.
Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xv 8. Chapter One: Role of ESCRT pathway and autophagy in neurodegenerative diseases - p. 1 9. Chapter Two: Bioenergetic impairment-induced Tau acetylation: Converging pathways in Alzheimer’s disease - p. 17 10. Chapter Three: Insulin resistance and obesity: Drivers of energy crisis for Alzheimer’s disease - p. 39 11. Chapter Four: Therapeutic targeting of brain bioenergetics in Alzheimer’s disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction - p. 91 12. Chapter Five: Crosstalk in Alzheimer’s-delirium nexus: Molecular mechanisms and therapeutic repurposing - p. 133 13. Chapter Six: Genetic and epigenetic complexity of Parkinson’s disease: From dopamine pathways to estrogen interplay - p. 159 14. Chapter Seven: Metallospecies and their biological functions in Alzheimer’s disease - p. 193 15. Chapter Eight: Liquid–liquid phase separation of tau in Alzheimer’s disease - p. 219 16. Chapter Nine: Metabolic reprogramming in Alzheimer’s disease: Interaction between receptor tyrosine kinase signaling, noncoding RNAs, and Neuron–Glia energy networks - p. 281 17. Chapter Ten: Activation of Nrf2 neuroprotective pathways for treatment of Parkinson’s disease: A state of art review - p. 331 18. Chapter Eleven: Metabolic drivers of Alzheimer’s disease pathogenesis: Impairments in glucose utilization, lipid homeostasis, and alternative substrate metabolism - p. 349 19. Chapter Twelve: Glial molecular signatures as a liquid biopsy marker in Alzheimer’s disease diagnosis - p. 385
Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.
Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.
Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xv 8. Chapter One: Role of ESCRT pathway and autophagy in neurodegenerative diseases - p. 1 9. Chapter Two: Bioenergetic impairment-induced Tau acetylation: Converging pathways in Alzheimer’s disease - p. 17 10. Chapter Three: Insulin resistance and obesity: Drivers of energy crisis for Alzheimer’s disease - p. 39 11. Chapter Four: Therapeutic targeting of brain bioenergetics in Alzheimer’s disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction - p. 91 12. Chapter Five: Crosstalk in Alzheimer’s-delirium nexus: Molecular mechanisms and therapeutic repurposing - p. 133 13. Chapter Six: Genetic and epigenetic complexity of Parkinson’s disease: From dopamine pathways to estrogen interplay - p. 159 14. Chapter Seven: Metallospecies and their biological functions in Alzheimer’s disease - p. 193 15. Chapter Eight: Liquid–liquid phase separation of tau in Alzheimer’s disease - p. 219 16. Chapter Nine: Metabolic reprogramming in Alzheimer’s disease: Interaction between receptor tyrosine kinase signaling, noncoding RNAs, and Neuron–Glia energy networks - p. 281 17. Chapter Ten: Activation of Nrf2 neuroprotective pathways for treatment of Parkinson’s disease: A state of art review - p. 331 18. Chapter Eleven: Metabolic drivers of Alzheimer’s disease pathogenesis: Impairments in glucose utilization, lipid homeostasis, and alternative substrate metabolism - p. 349 19. Chapter Twelve: Glial molecular signatures as a liquid biopsy marker in Alzheimer’s disease diagnosis - p. 385
