Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.
1. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. iv 7. Contributors - p. xxi 8. Preface - p. xxvii 9. Chapter 1 Fall-related traumatic brain injuries in older adults: The role of the neck - p. 3 10. Chapter 2 The implications of sex and gender in traumatic brain injury - p. 13 11. Chapter 3 Sport-related concussion: The role of repetitive head impact exposure - p. 29 12. Chapter 4 Traumatic brain injury and molecular biology: A new narrative - p. 41 13. Chapter 5 Features of decompressive craniectomy in traumatic brain injury: History, effects, management, and new trends - p. 55 14. Chapter 6 Management of traumatic brain injury in accordance with contemporary guidelines: Treatment, monitoring, and thresholds - p. 67 15. Chapter 7 Insights into the pathological role of neuroinflammatory responses in traumatic brain injury - p. 81 16. Chapter 8 Seizures in traumatic brain injury: A focus on cellular aspects - p. 95 17. Chapter 9 Linking traumatic brain injury, neural stem, and progenitor cells - p. 107 18. Chapter 10 Microglia in traumatic brain injury - p. 121 19. Chapter 11 Dendritic spine plasticity and traumatic brain injury - p. 135 20. Chapter 12 Aging, the immune response, and traumatic brain injury - p. 149 21. Chapter 13 The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes - p. 161 22. Chapter 14 The role of regulatory T cells in traumatic brain injury - p. 175 23. Chapter 15 The role of the chemokine prokineticin 2 in traumatic brain injury - p. 185 24. Chapter 16 The role of Na+,K+-ATPase on TBI-induced physiopathology - p. 195 25. Chapter 17 Pyruvate dehydrogenase complex, metabolic enzymes, and energy derangement in traumatic brain injury - p. 207 26. Chapter 18 Angiopoietin-1/Tie-2 signaling in traumatic brain injury - p. 219 27. Chapter 19 Brain microdialysis and applications to drug therapy in severe traumatic brain injury - p. 231 28. Chapter 20 Comparing radiation and traumatic brain injuries: New insights - p. 243 29. Chapter 21 Sodium dysregulation in traumatic brain injury - p. 257 30. Chapter 22 WNT genes and their roles in traumatic brain injury - p. 267 31. Chapter 23 Circuit reorganization after diffuse axonal injury: Utility of the whisker barrel circuit - p. 281 32. Chapter 24 Neuroendocrine abnormalities following traumatic brain injury - p. 293 33. Chapter 25 Thyroid hormone actions in traumatic brain injury - p. 305 34. Chapter 26 Testosterone: Features and role in treating traumatic brain injury - p. 317 35. Chapter 27 The rate of empty sella (ES) in traumatic brain injury: Links with endocrine profiles - p. 325 36. Chapter 28 Traumatic brain injury: Inter-relationship with sleep - p. 341 37. Chapter 29 Puberty and traumatic brain injury - p. 351 38. Chapter 30 Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury - p. 363 39. Chapter 31 Imaging connectivity and functional brain networks in mild traumatic brain injury - p. 379 40. Chapter 32 Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory - p. 393 41. Chapter 33 Monitoring real-time changes in physiology: Multi-modality neurologic monitoring for pediatric traumatic brain injury - p. 405 42. Chapter 34 Blood gas, arterial, and end-tidal carbon dioxide in traumatic brain injury - p. 421 43. Chapter 35 Disturbances of cerebral microcirculation in traumatic brain injury: The role of changes in microcirculatory biomarkers - p. 433 44. Chapter 36 Social cognition in traumatic brain injury - p. 447 45. Chapter 37 Physical exercise: Effects on cognitive function after traumatic brain injury - p. 461 46. Chapter 38 Traumatic axonal injury as a key driver of the relationship between traumatic brain injury, cognitive dysfunction, and dementia - p. 475 47. Chapter 39 Neuropsychological functioning of children and youth after traumatic brain injury - p. 487 48. Chapter 40 Behavioral effects of traumatic brain injury: Use of guanosine - p. 501 49. Chapter 41 Recognizing emotions and effects of traumatic brain injury - p. 515 50. Chapter 42 Cognitive communication connections and higher-level language with traumatic brain-injured population - p. 527 51. Chapter 43 Self-awareness after severe traumatic brain injury: From impairment of self-awareness to psychological adjustment - p. 539 52. Chapter 44 Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies - p. 553 53. Chapter 45 The link between sleep and quality of life in childhood traumatic brain injury - p. 563 54. Index - p. 575 55. Index - Continued - p. 582
Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.
1. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. iv 7. Contributors - p. xxi 8. Preface - p. xxvii 9. Chapter 1 Fall-related traumatic brain injuries in older adults: The role of the neck - p. 3 10. Chapter 2 The implications of sex and gender in traumatic brain injury - p. 13 11. Chapter 3 Sport-related concussion: The role of repetitive head impact exposure - p. 29 12. Chapter 4 Traumatic brain injury and molecular biology: A new narrative - p. 41 13. Chapter 5 Features of decompressive craniectomy in traumatic brain injury: History, effects, management, and new trends - p. 55 14. Chapter 6 Management of traumatic brain injury in accordance with contemporary guidelines: Treatment, monitoring, and thresholds - p. 67 15. Chapter 7 Insights into the pathological role of neuroinflammatory responses in traumatic brain injury - p. 81 16. Chapter 8 Seizures in traumatic brain injury: A focus on cellular aspects - p. 95 17. Chapter 9 Linking traumatic brain injury, neural stem, and progenitor cells - p. 107 18. Chapter 10 Microglia in traumatic brain injury - p. 121 19. Chapter 11 Dendritic spine plasticity and traumatic brain injury - p. 135 20. Chapter 12 Aging, the immune response, and traumatic brain injury - p. 149 21. Chapter 13 The adaptive immune system in traumatic brain injury: A focus on T and B lymphocytes - p. 161 22. Chapter 14 The role of regulatory T cells in traumatic brain injury - p. 175 23. Chapter 15 The role of the chemokine prokineticin 2 in traumatic brain injury - p. 185 24. Chapter 16 The role of Na+,K+-ATPase on TBI-induced physiopathology - p. 195 25. Chapter 17 Pyruvate dehydrogenase complex, metabolic enzymes, and energy derangement in traumatic brain injury - p. 207 26. Chapter 18 Angiopoietin-1/Tie-2 signaling in traumatic brain injury - p. 219 27. Chapter 19 Brain microdialysis and applications to drug therapy in severe traumatic brain injury - p. 231 28. Chapter 20 Comparing radiation and traumatic brain injuries: New insights - p. 243 29. Chapter 21 Sodium dysregulation in traumatic brain injury - p. 257 30. Chapter 22 WNT genes and their roles in traumatic brain injury - p. 267 31. Chapter 23 Circuit reorganization after diffuse axonal injury: Utility of the whisker barrel circuit - p. 281 32. Chapter 24 Neuroendocrine abnormalities following traumatic brain injury - p. 293 33. Chapter 25 Thyroid hormone actions in traumatic brain injury - p. 305 34. Chapter 26 Testosterone: Features and role in treating traumatic brain injury - p. 317 35. Chapter 27 The rate of empty sella (ES) in traumatic brain injury: Links with endocrine profiles - p. 325 36. Chapter 28 Traumatic brain injury: Inter-relationship with sleep - p. 341 37. Chapter 29 Puberty and traumatic brain injury - p. 351 38. Chapter 30 Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury - p. 363 39. Chapter 31 Imaging connectivity and functional brain networks in mild traumatic brain injury - p. 379 40. Chapter 32 Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory - p. 393 41. Chapter 33 Monitoring real-time changes in physiology: Multi-modality neurologic monitoring for pediatric traumatic brain injury - p. 405 42. Chapter 34 Blood gas, arterial, and end-tidal carbon dioxide in traumatic brain injury - p. 421 43. Chapter 35 Disturbances of cerebral microcirculation in traumatic brain injury: The role of changes in microcirculatory biomarkers - p. 433 44. Chapter 36 Social cognition in traumatic brain injury - p. 447 45. Chapter 37 Physical exercise: Effects on cognitive function after traumatic brain injury - p. 461 46. Chapter 38 Traumatic axonal injury as a key driver of the relationship between traumatic brain injury, cognitive dysfunction, and dementia - p. 475 47. Chapter 39 Neuropsychological functioning of children and youth after traumatic brain injury - p. 487 48. Chapter 40 Behavioral effects of traumatic brain injury: Use of guanosine - p. 501 49. Chapter 41 Recognizing emotions and effects of traumatic brain injury - p. 515 50. Chapter 42 Cognitive communication connections and higher-level language with traumatic brain-injured population - p. 527 51. Chapter 43 Self-awareness after severe traumatic brain injury: From impairment of self-awareness to psychological adjustment - p. 539 52. Chapter 44 Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies - p. 553 53. Chapter 45 The link between sleep and quality of life in childhood traumatic brain injury - p. 563 54. Index - p. 575 55. Index - Continued - p. 582
