Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
1. Aging, Cellular Senescence, and Chromatin: an Introduction - p. 288 2. Nucleosomal Modifications in Senescence and Aging - p. 290 3. Histone Posttranslational Modifications During Cellular Senescence and Aging - p. 293 4. Modulation of Lifespan by Experimental Alteration of Chromatin Modifiers in Animal Models - p. 297 5. Age-Dependent Regulation of the Chromatin-Metabolism Connection - p. 300 6. Effect of Telomere Shortening on Telomeric Chromatin - p. 301 7. Conclusion - p. 302 8. List of Acronyms and Abbreviations - p. 303 9. Chapter 17. Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells - p. 311 10. Chapter 18. Altered Chromatin Signaling in Cancer - p. 329 11. Chapter 19. Impact of Chromatin Changes in Pathogenesis of Infectious Diseases: A Pathogen View - p. 347 12. Chapter 20. Chromatin Remodeling and Epigenetic Reprogramming in Chronic Disease and Cancer in the Liver and Pancreas - p. 365 13. Chapter 21. Pharmacological and Therapeutic Targeting of Epigenetic Regulators - p. 387 14. Chapter 22. Use of Chromatin Changes as Biomarkers - p. 403 15. Chapter 23. Regulation of Host Chromatin by Bacterial Metabolites - p. 423 16. Introduction - p. 423 17. The Commensal Bacterial Metabolome - p. 424 18. Dietary Carcinogens Alter Chromatin - p. 424 19. Bile Acids: Microbial Bile-ome and Nuclear Receptors - p. 425 20. Estrogens: Microbial Estrabolome and Chromatin Modulation - p. 426 21. Ellagic Acid and Histones Methylation - p. 426 22. Short Chain Fatty Acids (SCFAs), G Protein–Coupled Receptors, and Histone Deacetylases - p. 426 23. Indoles and Nuclear Receptors - p. 427 24. Polyketides - p. 430 25. Bacterial Nucleomodulins - p. 431 26. Miscellaneous - p. 431 27. Non-Mammalian Systems - p. 431 28. Plants - p. 432 29. Lessons to Apply from Host Intermediary Metabolism and Chromatin - p. 432 30. Metabolite Mining for Chromatin Modulation - p. 433 31. Conclusion - p. 435 32. List of Acronyms and Abbreviations - p. 435 33. Index - p. 443
Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.
Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.
1. Aging, Cellular Senescence, and Chromatin: an Introduction - p. 288 2. Nucleosomal Modifications in Senescence and Aging - p. 290 3. Histone Posttranslational Modifications During Cellular Senescence and Aging - p. 293 4. Modulation of Lifespan by Experimental Alteration of Chromatin Modifiers in Animal Models - p. 297 5. Age-Dependent Regulation of the Chromatin-Metabolism Connection - p. 300 6. Effect of Telomere Shortening on Telomeric Chromatin - p. 301 7. Conclusion - p. 302 8. List of Acronyms and Abbreviations - p. 303 9. Chapter 17. Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells - p. 311 10. Chapter 18. Altered Chromatin Signaling in Cancer - p. 329 11. Chapter 19. Impact of Chromatin Changes in Pathogenesis of Infectious Diseases: A Pathogen View - p. 347 12. Chapter 20. Chromatin Remodeling and Epigenetic Reprogramming in Chronic Disease and Cancer in the Liver and Pancreas - p. 365 13. Chapter 21. Pharmacological and Therapeutic Targeting of Epigenetic Regulators - p. 387 14. Chapter 22. Use of Chromatin Changes as Biomarkers - p. 403 15. Chapter 23. Regulation of Host Chromatin by Bacterial Metabolites - p. 423 16. Introduction - p. 423 17. The Commensal Bacterial Metabolome - p. 424 18. Dietary Carcinogens Alter Chromatin - p. 424 19. Bile Acids: Microbial Bile-ome and Nuclear Receptors - p. 425 20. Estrogens: Microbial Estrabolome and Chromatin Modulation - p. 426 21. Ellagic Acid and Histones Methylation - p. 426 22. Short Chain Fatty Acids (SCFAs), G Protein–Coupled Receptors, and Histone Deacetylases - p. 426 23. Indoles and Nuclear Receptors - p. 427 24. Polyketides - p. 430 25. Bacterial Nucleomodulins - p. 431 26. Miscellaneous - p. 431 27. Non-Mammalian Systems - p. 431 28. Plants - p. 432 29. Lessons to Apply from Host Intermediary Metabolism and Chromatin - p. 432 30. Metabolite Mining for Chromatin Modulation - p. 433 31. Conclusion - p. 435 32. List of Acronyms and Abbreviations - p. 435 33. Index - p. 443
