‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’
The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.
1. Introduction - p. 1 2. Chapter 1 Clinical pharmacology - p. 2 3. Chapter 2 Topics in drug therapy - p. 5 4. Chapter 3 Discovery and development of drugs - p. 28 5. Chapter 4 Evaluation of drugs in humans - p. 37 6. Chapter 5 Health technology assessment - p. 56 7. Chapter 6 Regulation of medicines - p. 63 8. Chapter 7 Classification and naming of drugs - p. 71 9. Section 2 From pharmacology to toxicology - p. 74 10. Introduction - p. 75 11. Chapter 8 General pharmacology - p. 76 12. Chapter 9 Unwanted effects and adverse drug reactions - p. 112 13. Chapter 10 Poisoning, overdose, antidotes - p. 125 14. Chapter 11 Drug dependence - p. 139 15. Section 3 Infection and inflammation - p. 164 16. Introduction - p. 165 17. Chapter 12 Chemotherapy of infections - p. 166 18. Chapter 13 Antibacterial drugs - p. 178 19. Chapter 14 Chemotherapy of bacterial infections - p. 198 20. Chapter 15 Viral, fungal, protozoal and helminthic infections - p. 221 21. Chapter 16 Drugs for inflammation and joint disease - p. 248 22. Chapter 17 Drugs and the skin - p. 269 23. Section 4 Nervous system - p. 285 24. Introduction - p. 287 25. Chapter 18 Pain and analgesics - p. 288 26. Chapter 19 Anaesthesia and neuromuscular block - p. 308 27. Chapter 20 Psychotropic drugs - p. 324 28. Chapter 21 Neurological disorders – epilepsy, Parkinson's disease and multiple sclerosis - p. 365 29. Section 5 Cardiorespiratory and renal systems - p. 389 30. Introduction - p. 391 31. Chapter 22 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs - p. 392 32. Chapter 23 Adrenergic mechanisms and drugs - p. 403 33. Chapter 24 Arterial hypertension, angina pectoris, myocardial infarction and heart failure - p. 415 34. Chapter 25 Cardiac arrhythmia - p. 451 35. Chapter 26 Hyperlipidaemias - p. 468 36. Chapter 27 Kidney and genitourinary tract - p. 479 37. Chapter 28 Respiratory system - p. 495 38. Section 6 Blood and neoplastic disease - p. 510 39. Introduction - p. 511 40. Chapter 29 Drugs and haemostasis - p. 512 41. Chapter 30 Red blood cell disorders - p. 528 42. Chapter 31 Neoplastic disease and immunosuppression - p. 543 43. Section 7 Gastrointestinal system - p. 560 44. Introduction - p. 561 45. Chapter 32 Oesophagus, stomach and duodenum - p. 562 46. Chapter 33 Intestines - p. 570 47. Chapter 34 Liver and biliary tract - p. 581 48. Section 8 Endocrine system, metabolic conditions - p. 592 49. Introduction - p. 593 50. Chapter 35 Adrenal corticosteroids, antagonists, corticotropin - p. 594 51. Chapter 36 Diabetes mellitus, insulin, oral antidiabetes agents, obesity - p. 608 52. Chapter 37 Thyroid hormones, antithyroid drugs - p. 625 53. Chapter 38 Hypothalamic, pituitary and sex hormones - p. 635 54. Chapter 39 Vitamins, calcium, bone - p. 655 55. Index - p. 667
‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’
The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.
1. Introduction - p. 1 2. Chapter 1 Clinical pharmacology - p. 2 3. Chapter 2 Topics in drug therapy - p. 5 4. Chapter 3 Discovery and development of drugs - p. 28 5. Chapter 4 Evaluation of drugs in humans - p. 37 6. Chapter 5 Health technology assessment - p. 56 7. Chapter 6 Regulation of medicines - p. 63 8. Chapter 7 Classification and naming of drugs - p. 71 9. Section 2 From pharmacology to toxicology - p. 74 10. Introduction - p. 75 11. Chapter 8 General pharmacology - p. 76 12. Chapter 9 Unwanted effects and adverse drug reactions - p. 112 13. Chapter 10 Poisoning, overdose, antidotes - p. 125 14. Chapter 11 Drug dependence - p. 139 15. Section 3 Infection and inflammation - p. 164 16. Introduction - p. 165 17. Chapter 12 Chemotherapy of infections - p. 166 18. Chapter 13 Antibacterial drugs - p. 178 19. Chapter 14 Chemotherapy of bacterial infections - p. 198 20. Chapter 15 Viral, fungal, protozoal and helminthic infections - p. 221 21. Chapter 16 Drugs for inflammation and joint disease - p. 248 22. Chapter 17 Drugs and the skin - p. 269 23. Section 4 Nervous system - p. 285 24. Introduction - p. 287 25. Chapter 18 Pain and analgesics - p. 288 26. Chapter 19 Anaesthesia and neuromuscular block - p. 308 27. Chapter 20 Psychotropic drugs - p. 324 28. Chapter 21 Neurological disorders – epilepsy, Parkinson's disease and multiple sclerosis - p. 365 29. Section 5 Cardiorespiratory and renal systems - p. 389 30. Introduction - p. 391 31. Chapter 22 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs - p. 392 32. Chapter 23 Adrenergic mechanisms and drugs - p. 403 33. Chapter 24 Arterial hypertension, angina pectoris, myocardial infarction and heart failure - p. 415 34. Chapter 25 Cardiac arrhythmia - p. 451 35. Chapter 26 Hyperlipidaemias - p. 468 36. Chapter 27 Kidney and genitourinary tract - p. 479 37. Chapter 28 Respiratory system - p. 495 38. Section 6 Blood and neoplastic disease - p. 510 39. Introduction - p. 511 40. Chapter 29 Drugs and haemostasis - p. 512 41. Chapter 30 Red blood cell disorders - p. 528 42. Chapter 31 Neoplastic disease and immunosuppression - p. 543 43. Section 7 Gastrointestinal system - p. 560 44. Introduction - p. 561 45. Chapter 32 Oesophagus, stomach and duodenum - p. 562 46. Chapter 33 Intestines - p. 570 47. Chapter 34 Liver and biliary tract - p. 581 48. Section 8 Endocrine system, metabolic conditions - p. 592 49. Introduction - p. 593 50. Chapter 35 Adrenal corticosteroids, antagonists, corticotropin - p. 594 51. Chapter 36 Diabetes mellitus, insulin, oral antidiabetes agents, obesity - p. 608 52. Chapter 37 Thyroid hormones, antithyroid drugs - p. 625 53. Chapter 38 Hypothalamic, pituitary and sex hormones - p. 635 54. Chapter 39 Vitamins, calcium, bone - p. 655 55. Index - p. 667
