Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios.
As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.
1. Chapter 1 Introduction to plant metabolite profiling: Concepts and techniques - p. 1 2. Chapter 2 Plant metabolite profiling: Techniques and theoretical framework - p. 27 3. Chapter 3 Environmental metabolomics: Unravelling plant responses to abiotic stress - p. 47 4. Chapter 4 Metabolic engineering strategies for enhanced plant metabolite production - p. 63 5. Chapter 5 Optimizing plant metabolite production through metabolic engineering strategies - p. 79 6. Chapter 6 Mass spectrometry in plant metabolomics: Advances and applications in a practical protocol - p. 95 7. Chapter 7 Mass Spectrometry–Data Independent AnaLysis, an open-source platform for global metabolomics and lipidomics data processing, annotation, and visualization - p. 109 8. Chapter 8 Nuclear magnetic resonance spectroscopy for plant metabolite analysis - p. 133 9. Chapter 9 Applications of nuclear magnetic resonance spectroscopy in plant metabolite analysis for drug discovery - p. 157 10. Chapter 10 High-performance liquid chromatography in plant metabolomics - p. 179 11. Chapter 11 Metabolite imaging techniques: From principles to applications - p. 213 12. Chapter 12 Isotope tracing and fluxomics in plant metabolism studies - p. 221 13. Chapter 13 Nuclear magnetic resonance (NMR) spectroscopy in plant metabolite analysis: Applications in drug discovery - p. 233 14. Chapter 14 Ambient ionization techniques for rapid metabolite profiling in plant-based drug development - p. 255 15. Chapter 15 Microfluidics for high-throughput plant metabolite profiling - p. 271 16. Chapter 16 Emerging trends in metabolite profiling using microfluidics and lab-on-a-chip technologies - p. 281 17. Chapter 17 Metabolomics in crop improvement: Breeding for bioactive compounds - p. 299 18. Chapter 18 Metabolomics for crop breeding: Enhancing bioactive compound profiles - p. 321 19. Chapter 19 Metabolite profiling of endophytic microorganisms for drug discovery - p. 353 20. Chapter 20 Profiling bioactive metabolites of endophytes for drug discovery applications - p. 377 21. Chapter 21 Quality control and standardization of herbal medicines - p. 393 22. Chapter 22 Enhancing herbal medicine quality control through advanced fingerprint analysis - p. 407 23. Chapter 23 Enhancing quality control for herbal remedies with advanced fingerprint analysis - p. 417 24. Chapter 24 Discovery of bioactive-chemical Q-markers for quality control of plant medicine - p. 433 25. Chapter 25 Integrative approaches of metabolomics and DNA barcoding for identifying combinatorial discriminatory quality markers - p. 453 26. Chapter 26 Combining strategy of metabolomics and transcriptomics to identify medicinal properties of plants - p. 465 27. Chapter 27 Integrating metabolomics and transcriptomics to uncover medicinal properties of plants - p. 483 28. Chapter 28 Advanced computational methods and machine learning for metabolite identification and quantification in plant-derived drugs - p. 507 29. Chapter 29 Integration of plant metabolomics with systems biology approaches (Case studies) - p. 537 30. Chapter 30 Data analysis and bioinformatics tools for plant metabolomics - p. 553 31. Chapter 31 Regulatory considerations in plant-derived drugdevelopment - p. 575 32. Chapter 32 A Unified framework for the application of plant metabolomics advancement in industries - p. 587 33. Chapter 33 Implication of metabolomics signature in archaeological examinations - p. 605 34. Chapter 34 Environmental metabolomics: Monitoring plant responses to stressors - p. 625 35. Index - p. 653
Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control offers a comprehensive exploration of advanced methods in plant metabolomics, along with their integration in industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods, and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations, and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios.
As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.
1. Chapter 1 Introduction to plant metabolite profiling: Concepts and techniques - p. 1 2. Chapter 2 Plant metabolite profiling: Techniques and theoretical framework - p. 27 3. Chapter 3 Environmental metabolomics: Unravelling plant responses to abiotic stress - p. 47 4. Chapter 4 Metabolic engineering strategies for enhanced plant metabolite production - p. 63 5. Chapter 5 Optimizing plant metabolite production through metabolic engineering strategies - p. 79 6. Chapter 6 Mass spectrometry in plant metabolomics: Advances and applications in a practical protocol - p. 95 7. Chapter 7 Mass Spectrometry–Data Independent AnaLysis, an open-source platform for global metabolomics and lipidomics data processing, annotation, and visualization - p. 109 8. Chapter 8 Nuclear magnetic resonance spectroscopy for plant metabolite analysis - p. 133 9. Chapter 9 Applications of nuclear magnetic resonance spectroscopy in plant metabolite analysis for drug discovery - p. 157 10. Chapter 10 High-performance liquid chromatography in plant metabolomics - p. 179 11. Chapter 11 Metabolite imaging techniques: From principles to applications - p. 213 12. Chapter 12 Isotope tracing and fluxomics in plant metabolism studies - p. 221 13. Chapter 13 Nuclear magnetic resonance (NMR) spectroscopy in plant metabolite analysis: Applications in drug discovery - p. 233 14. Chapter 14 Ambient ionization techniques for rapid metabolite profiling in plant-based drug development - p. 255 15. Chapter 15 Microfluidics for high-throughput plant metabolite profiling - p. 271 16. Chapter 16 Emerging trends in metabolite profiling using microfluidics and lab-on-a-chip technologies - p. 281 17. Chapter 17 Metabolomics in crop improvement: Breeding for bioactive compounds - p. 299 18. Chapter 18 Metabolomics for crop breeding: Enhancing bioactive compound profiles - p. 321 19. Chapter 19 Metabolite profiling of endophytic microorganisms for drug discovery - p. 353 20. Chapter 20 Profiling bioactive metabolites of endophytes for drug discovery applications - p. 377 21. Chapter 21 Quality control and standardization of herbal medicines - p. 393 22. Chapter 22 Enhancing herbal medicine quality control through advanced fingerprint analysis - p. 407 23. Chapter 23 Enhancing quality control for herbal remedies with advanced fingerprint analysis - p. 417 24. Chapter 24 Discovery of bioactive-chemical Q-markers for quality control of plant medicine - p. 433 25. Chapter 25 Integrative approaches of metabolomics and DNA barcoding for identifying combinatorial discriminatory quality markers - p. 453 26. Chapter 26 Combining strategy of metabolomics and transcriptomics to identify medicinal properties of plants - p. 465 27. Chapter 27 Integrating metabolomics and transcriptomics to uncover medicinal properties of plants - p. 483 28. Chapter 28 Advanced computational methods and machine learning for metabolite identification and quantification in plant-derived drugs - p. 507 29. Chapter 29 Integration of plant metabolomics with systems biology approaches (Case studies) - p. 537 30. Chapter 30 Data analysis and bioinformatics tools for plant metabolomics - p. 553 31. Chapter 31 Regulatory considerations in plant-derived drugdevelopment - p. 575 32. Chapter 32 A Unified framework for the application of plant metabolomics advancement in industries - p. 587 33. Chapter 33 Implication of metabolomics signature in archaeological examinations - p. 605 34. Chapter 34 Environmental metabolomics: Monitoring plant responses to stressors - p. 625 35. Index - p. 653
