Since its first publication 75 years ago, Davidson's Principles and Practice of Medicine has kept pace with how modern medicine is taught, providing a wealth of trusted information in an easy-to-read, concise, and beautifully illustrated format. Now in its 25th edition, this classic text with origins in Sir Stanley Davidson’s much admired lecture notes has been owned by more than two million medical students, doctors, and other health professionals around the globe. Carefully updated content describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine, and explains how to recognise, investigate, diagnose and manage them.
Davidson’s serves readers everywhere as a core text that integrates medical science with clinical medicine, conveying key knowledge and practical advice in a highly accessible and readable format.
1. Introduction - p. xix 2. Part 1: Fundamentals of Medicine - p. P1 3. 1. Clinical decision-making - p. 1 4. 2. Clinical therapeutics and good prescribing - p. 13 5. 3. Clinical genetics - p. 35 6. 4. Clinical immunology - p. 57 7. 5. Nutritional factors in disease - p. 87 8. 6. Population health and epidemiology - p. 115 9. 7. Principles of infection - p. 125 10. 8. Oncology - p. 157 11. 9. Palliative and supportive care - p. 187 12. Part 2: Emergency and Critical Care Medicine - p. P211 13. 10. Acute medicine and critical illness - p. 211 14. 11. Poisoning - p. 257 15. 12. Envenomation - p. 277 16. 13. Medicine in austere environments - p. 289 17. Part 3: Clinical Medicine - p. P299 18. 14. Infectious disease - p. 299 19. Abstract - p. 299 20. Clinical examination of patients with infectious disease - p. 300 21. Presenting problems in infectious diseases - p. 302 22. Infection in particular settings - p. 310 23. Viral infections - p. 319 24. Prion diseases - p. 353 25. Bacterial infections - p. 353 26. Protozoal infections - p. 373 27. Infections caused by helminths - p. 387 28. Ectoparasites - p. 398 29. Fungal infections - p. 398 30. Further information - p. 403 31. Multiple Choice Questions - p. 404 32. 15. Sexually transmitted infections - p. 405 33. 16. Cardiology - p. 421 34. Abstract - p. 421 35. Clinical examination of the cardiovascular system - p. 422 36. Functional anatomy and physiology - p. 424 37. Investigation of cardiovascular disease - p. 427 38. Presenting problems in cardiovascular disease - p. 433 39. Cardiac arrhythmias - p. 444 40. Principles of management of cardiac arrhythmias - p. 455 41. Coronary artery disease - p. 460 42. Peripheral arterial disease - p. 476 43. Diseases of the aorta - p. 479 44. Diseases of the heart valves - p. 487 45. Congenital heart disease - p. 503 46. Diseases of the myocardium - p. 509 47. Diseases of the pericardium - p. 513 48. Further information - p. 515 49. Multiple Choice Questions - p. 516 50. 17. Respiratory medicine - p. 517 51. Abstract - p. 517 52. Clinical examination of the respiratory system - p. 518 53. Functional anatomy and physiology - p. 520 54. Investigation of respiratory disease - p. 522 55. Presenting problems in respiratory disease - p. 527 56. Obstructive pulmonary diseases - p. 537 57. Infections of the respiratory system - p. 550 58. Tumours of the bronchus and lung - p. 567 59. Interstitial and infiltrative pulmonary diseases - p. 573 60. Occupational and environmental lung disease - p. 581 61. Pulmonary vascular disease - p. 586 62. Diseases of the upper airway - p. 589 63. Pleural disease - p. 593 64. Diseases of the diaphragm and chest wall - p. 594 65. Further information - p. 595 66. Multiple Choice Questions - p. 596 67. 18. Nephrology and urology - p. 597 68. 19. Clinical biochemistry and metabolic medicine - p. 655 69. 20. Endocrinology - p. 689 70. 21. Diabetes mellitus - p. 745 71. 22. Gastroenterology - p. 799 72. Abstract - p. 799 73. Clinical examination of the gastrointestinal tract - p. 800 74. Functional anatomy and physiology - p. 802 75. Investigation of gastrointestinal disease - p. 807 76. Presenting problems in gastrointestinal disease - p. 813 77. Disorders of the mouth and salivary glands - p. 823 78. Disorders of the oesophagus - p. 824 79. Disorders of the stomach and duodenum - p. 830 80. Disorders of the small intestine - p. 837 81. Disorders of the colon and rectum - p. 844 82. Inflammatory bowel disease - p. 853 83. Functional bowel disorders - p. 865 84. Ischaemic gut injury - p. 867 85. Diseases of the pancreas - p. 868 86. Diseases of the peritoneal cavity - p. 875 87. Other disorders - p. 875 88. Further information - p. 875 89. Multiple Choice Questions - p. 876 90. 23. Hepatology - p. 877 91. 24. Haematology and transfusion medicine - p. 941 92. Abstract - p. 941 93. Clinical examination in blood disease - p. 942 94. Functional anatomy and physiology - p. 944 95. Investigation of diseases of the blood - p. 950 96. Presenting problems in blood disease - p. 952 97. Principles of management of haematological disease - p. 959 98. Anaemias - p. 971 99. Haemoglobinopathies - p. 981 100. Haematological malignancies - p. 984 101. Aplastic anaemia - p. 1004 102. Myeloproliferative neoplasms - p. 1004 103. Bleeding disorders - p. 1005 104. Thrombotic disorders - p. 1010 105. Further information - p. 1014 106. Multiple Choice Questions - p. 1014 107. 25. Rheumatology and bone disease - p. 1015 108. Abstract - p. 1015 109. Clinical examination of the musculoskeletal system - p. 1016 110. Functional anatomy and physiology - p. 1018 111. Investigation of musculoskeletal disease - p. 1021 112. Presenting problems in musculoskeletal disease - p. 1025 113. Principles of management - p. 1033 114. Osteoarthritis - p. 1040 115. Crystal-induced arthritis/disease - p. 1044 116. Fibromyalgia - p. 1050 117. Bone and joint infections - p. 1050 118. Rheumatoid arthritis - p. 1052 119. Juvenile idiopathic arthritis - p. 1058 120. Spondyloarthritides - p. 1059 121. Autoimmune connective tissue diseases - p. 1064 122. Vasculitis - p. 1070 123. Diseases of bone - p. 1075 124. Bone and joint tumours - p. 1087 125. Rheumatological involvement in other diseases - p. 1088 126. Miscellaneous conditions - p. 1089 127. Further information - p. 1091 128. Multiple Choice Questions - p. 1092 129. 26. Dermatology - p. 1095 130. 27. Neurology and stroke medicine - p. 1149 131. Abstract - p. 1149 132. Clinical examination of the nervous system - p. 1149 133. Functional anatomy and physiology - p. 1152 134. Investigation of neurological disease - p. 1159 135. Presenting problems in neurological disease - p. 1167 136. Headache syndromes - p. 1180 137. Functional neurological disorder - p. 1183 138. Stroke - p. 1183 139. Subarachnoid haemorrhage - p. 1195 140. Cerebral venous disease - p. 1196 141. Epilepsy - p. 1197 142. Vestibular disorders - p. 1203 143. Disorders of sleep - p. 1204 144. Neuro-inflammatory diseases - p. 1205 145. Paraneoplastic neurological disorders - p. 1209 146. Neurodegenerative diseases - p. 1210 147. Infections of the nervous system - p. 1216 148. Intracranial mass lesions and raised intracranial pressure - p. 1226 149. Disorders of cerebellar function - p. 1232 150. Disorders of the spine and spinal cord - p. 1232 151. Diseases of peripheral nerves - p. 1235 152. Diseases of the neuromuscular junction - p. 1239 153. Diseases of muscle - p. 1240 154. Further information - p. 1243 155. Multiple Choice Questions - p. 1244 156. 28. Medical ophthalmology - p. 1245 157. 29. Medical psychiatry - p. 1267 158. 30. Maternal medicine - p. 1299 159. 31. Adolescence, transition and young adult medicine - p. 1317 160. 32. Older adult medicine and frailty - p. 1337 161. 33. Laboratory reference ranges - p. 1351 162. Index - p. 1361 163. Inside Back Cover - p. 1403
Since its first publication 75 years ago, Davidson's Principles and Practice of Medicine has kept pace with how modern medicine is taught, providing a wealth of trusted information in an easy-to-read, concise, and beautifully illustrated format. Now in its 25th edition, this classic text with origins in Sir Stanley Davidson’s much admired lecture notes has been owned by more than two million medical students, doctors, and other health professionals around the globe. Carefully updated content describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine, and explains how to recognise, investigate, diagnose and manage them.
Davidson’s serves readers everywhere as a core text that integrates medical science with clinical medicine, conveying key knowledge and practical advice in a highly accessible and readable format.
1. Introduction - p. xix 2. Part 1: Fundamentals of Medicine - p. P1 3. 1. Clinical decision-making - p. 1 4. 2. Clinical therapeutics and good prescribing - p. 13 5. 3. Clinical genetics - p. 35 6. 4. Clinical immunology - p. 57 7. 5. Nutritional factors in disease - p. 87 8. 6. Population health and epidemiology - p. 115 9. 7. Principles of infection - p. 125 10. 8. Oncology - p. 157 11. 9. Palliative and supportive care - p. 187 12. Part 2: Emergency and Critical Care Medicine - p. P211 13. 10. Acute medicine and critical illness - p. 211 14. 11. Poisoning - p. 257 15. 12. Envenomation - p. 277 16. 13. Medicine in austere environments - p. 289 17. Part 3: Clinical Medicine - p. P299 18. 14. Infectious disease - p. 299 19. Abstract - p. 299 20. Clinical examination of patients with infectious disease - p. 300 21. Presenting problems in infectious diseases - p. 302 22. Infection in particular settings - p. 310 23. Viral infections - p. 319 24. Prion diseases - p. 353 25. Bacterial infections - p. 353 26. Protozoal infections - p. 373 27. Infections caused by helminths - p. 387 28. Ectoparasites - p. 398 29. Fungal infections - p. 398 30. Further information - p. 403 31. Multiple Choice Questions - p. 404 32. 15. Sexually transmitted infections - p. 405 33. 16. Cardiology - p. 421 34. Abstract - p. 421 35. Clinical examination of the cardiovascular system - p. 422 36. Functional anatomy and physiology - p. 424 37. Investigation of cardiovascular disease - p. 427 38. Presenting problems in cardiovascular disease - p. 433 39. Cardiac arrhythmias - p. 444 40. Principles of management of cardiac arrhythmias - p. 455 41. Coronary artery disease - p. 460 42. Peripheral arterial disease - p. 476 43. Diseases of the aorta - p. 479 44. Diseases of the heart valves - p. 487 45. Congenital heart disease - p. 503 46. Diseases of the myocardium - p. 509 47. Diseases of the pericardium - p. 513 48. Further information - p. 515 49. Multiple Choice Questions - p. 516 50. 17. Respiratory medicine - p. 517 51. Abstract - p. 517 52. Clinical examination of the respiratory system - p. 518 53. Functional anatomy and physiology - p. 520 54. Investigation of respiratory disease - p. 522 55. Presenting problems in respiratory disease - p. 527 56. Obstructive pulmonary diseases - p. 537 57. Infections of the respiratory system - p. 550 58. Tumours of the bronchus and lung - p. 567 59. Interstitial and infiltrative pulmonary diseases - p. 573 60. Occupational and environmental lung disease - p. 581 61. Pulmonary vascular disease - p. 586 62. Diseases of the upper airway - p. 589 63. Pleural disease - p. 593 64. Diseases of the diaphragm and chest wall - p. 594 65. Further information - p. 595 66. Multiple Choice Questions - p. 596 67. 18. Nephrology and urology - p. 597 68. 19. Clinical biochemistry and metabolic medicine - p. 655 69. 20. Endocrinology - p. 689 70. 21. Diabetes mellitus - p. 745 71. 22. Gastroenterology - p. 799 72. Abstract - p. 799 73. Clinical examination of the gastrointestinal tract - p. 800 74. Functional anatomy and physiology - p. 802 75. Investigation of gastrointestinal disease - p. 807 76. Presenting problems in gastrointestinal disease - p. 813 77. Disorders of the mouth and salivary glands - p. 823 78. Disorders of the oesophagus - p. 824 79. Disorders of the stomach and duodenum - p. 830 80. Disorders of the small intestine - p. 837 81. Disorders of the colon and rectum - p. 844 82. Inflammatory bowel disease - p. 853 83. Functional bowel disorders - p. 865 84. Ischaemic gut injury - p. 867 85. Diseases of the pancreas - p. 868 86. Diseases of the peritoneal cavity - p. 875 87. Other disorders - p. 875 88. Further information - p. 875 89. Multiple Choice Questions - p. 876 90. 23. Hepatology - p. 877 91. 24. Haematology and transfusion medicine - p. 941 92. Abstract - p. 941 93. Clinical examination in blood disease - p. 942 94. Functional anatomy and physiology - p. 944 95. Investigation of diseases of the blood - p. 950 96. Presenting problems in blood disease - p. 952 97. Principles of management of haematological disease - p. 959 98. Anaemias - p. 971 99. Haemoglobinopathies - p. 981 100. Haematological malignancies - p. 984 101. Aplastic anaemia - p. 1004 102. Myeloproliferative neoplasms - p. 1004 103. Bleeding disorders - p. 1005 104. Thrombotic disorders - p. 1010 105. Further information - p. 1014 106. Multiple Choice Questions - p. 1014 107. 25. Rheumatology and bone disease - p. 1015 108. Abstract - p. 1015 109. Clinical examination of the musculoskeletal system - p. 1016 110. Functional anatomy and physiology - p. 1018 111. Investigation of musculoskeletal disease - p. 1021 112. Presenting problems in musculoskeletal disease - p. 1025 113. Principles of management - p. 1033 114. Osteoarthritis - p. 1040 115. Crystal-induced arthritis/disease - p. 1044 116. Fibromyalgia - p. 1050 117. Bone and joint infections - p. 1050 118. Rheumatoid arthritis - p. 1052 119. Juvenile idiopathic arthritis - p. 1058 120. Spondyloarthritides - p. 1059 121. Autoimmune connective tissue diseases - p. 1064 122. Vasculitis - p. 1070 123. Diseases of bone - p. 1075 124. Bone and joint tumours - p. 1087 125. Rheumatological involvement in other diseases - p. 1088 126. Miscellaneous conditions - p. 1089 127. Further information - p. 1091 128. Multiple Choice Questions - p. 1092 129. 26. Dermatology - p. 1095 130. 27. Neurology and stroke medicine - p. 1149 131. Abstract - p. 1149 132. Clinical examination of the nervous system - p. 1149 133. Functional anatomy and physiology - p. 1152 134. Investigation of neurological disease - p. 1159 135. Presenting problems in neurological disease - p. 1167 136. Headache syndromes - p. 1180 137. Functional neurological disorder - p. 1183 138. Stroke - p. 1183 139. Subarachnoid haemorrhage - p. 1195 140. Cerebral venous disease - p. 1196 141. Epilepsy - p. 1197 142. Vestibular disorders - p. 1203 143. Disorders of sleep - p. 1204 144. Neuro-inflammatory diseases - p. 1205 145. Paraneoplastic neurological disorders - p. 1209 146. Neurodegenerative diseases - p. 1210 147. Infections of the nervous system - p. 1216 148. Intracranial mass lesions and raised intracranial pressure - p. 1226 149. Disorders of cerebellar function - p. 1232 150. Disorders of the spine and spinal cord - p. 1232 151. Diseases of peripheral nerves - p. 1235 152. Diseases of the neuromuscular junction - p. 1239 153. Diseases of muscle - p. 1240 154. Further information - p. 1243 155. Multiple Choice Questions - p. 1244 156. 28. Medical ophthalmology - p. 1245 157. 29. Medical psychiatry - p. 1267 158. 30. Maternal medicine - p. 1299 159. 31. Adolescence, transition and young adult medicine - p. 1317 160. 32. Older adult medicine and frailty - p. 1337 161. 33. Laboratory reference ranges - p. 1351 162. Index - p. 1361 163. Inside Back Cover - p. 1403