Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers delivers an up-to-date and complete overview of the range of biomedical applications for porous silicon nanomaterials, with a special emphasis on drug delivery. This book introduces the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, such as vaccine development, drug delivery, and tissue engineering. It also contains new insights on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, cancer immunotherapy, and more. Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers is of interest to researchers in the fields of materials science, nanotechnology, pharmaceutical science, biomedical engineering, and cancer research.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Table of Contents - p. v 5. Contributors - p. xiii 6. Chapter 1 Historical advancements in targeted nanoscale drug delivery systems - p. 1 7. Chapter 2 Synthesis of porous silicon–based nanoparticles - p. 29 8. Chapter 3 Characterization techniques for mesoporous silicon nanoparticles - p. 49 9. Chapter 4 Mesoporous silicon for solubility enhancement of drugs - p. 69 10. Chapter 5 Porous silicon–based nanocarriers for tumor targeting - p. 97 11. Chapter 6 Porous silica and related composites for topical drug delivery - p. 135 12. Chapter 7 Porous silicon nanocarriers for the management of neurodegenerative disorders - p. 163 13. Chapter 8 Functionalized silica nanocarriers for brain-targeted delivery - p. 191 14. Chapter 9 Porous silicon-based materials in nanoneedle and microneedle-based drug delivery systems - p. 233 15. Chapter 10 Porous silicon-based drug delivery carriers in cancer management - p. 263 16. Chapter 11 Stimuli-responsive silica nanoparticles: Smart systems for controlled drug delivery - p. 297 17. Chapter 12 Mesoporous silica-based nanocarriers in pulmonary drug delivery - p. 331 18. Chapter 13 Porous silicon nanoparticles in codelivery of drugs for improved cellular uptake and targeted drug delivery - p. 365 19. Chapter 14 Recent advances in porous silicon–based technology for biomedical applications - p. 399 20. Chapter 15 Immunotherapeutic applications of porous silicon nanoparticles - p. 427 21. Chapter 16 Bioengineered porous silicon nanoparticles in vaccine development - p. 445 22. Chapter 17 Bioavailability enhancement of poorly soluble drugs with mesoporous silicon - p. 469 23. Chapter 18 Silica nanoparticles in clinical trials - p. 491 24. Chapter 19 Mesoporous silica nanoparticles for therapeutic uses: From bench to clinics - p. 507 25. Chapter 20 Future perspectives of mesoporous silica-based nanocarriers in drug delivery - p. 545 26. Index - p. 577
Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers delivers an up-to-date and complete overview of the range of biomedical applications for porous silicon nanomaterials, with a special emphasis on drug delivery. This book introduces the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, such as vaccine development, drug delivery, and tissue engineering. It also contains new insights on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, cancer immunotherapy, and more. Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers is of interest to researchers in the fields of materials science, nanotechnology, pharmaceutical science, biomedical engineering, and cancer research.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Table of Contents - p. v 5. Contributors - p. xiii 6. Chapter 1 Historical advancements in targeted nanoscale drug delivery systems - p. 1 7. Chapter 2 Synthesis of porous silicon–based nanoparticles - p. 29 8. Chapter 3 Characterization techniques for mesoporous silicon nanoparticles - p. 49 9. Chapter 4 Mesoporous silicon for solubility enhancement of drugs - p. 69 10. Chapter 5 Porous silicon–based nanocarriers for tumor targeting - p. 97 11. Chapter 6 Porous silica and related composites for topical drug delivery - p. 135 12. Chapter 7 Porous silicon nanocarriers for the management of neurodegenerative disorders - p. 163 13. Chapter 8 Functionalized silica nanocarriers for brain-targeted delivery - p. 191 14. Chapter 9 Porous silicon-based materials in nanoneedle and microneedle-based drug delivery systems - p. 233 15. Chapter 10 Porous silicon-based drug delivery carriers in cancer management - p. 263 16. Chapter 11 Stimuli-responsive silica nanoparticles: Smart systems for controlled drug delivery - p. 297 17. Chapter 12 Mesoporous silica-based nanocarriers in pulmonary drug delivery - p. 331 18. Chapter 13 Porous silicon nanoparticles in codelivery of drugs for improved cellular uptake and targeted drug delivery - p. 365 19. Chapter 14 Recent advances in porous silicon–based technology for biomedical applications - p. 399 20. Chapter 15 Immunotherapeutic applications of porous silicon nanoparticles - p. 427 21. Chapter 16 Bioengineered porous silicon nanoparticles in vaccine development - p. 445 22. Chapter 17 Bioavailability enhancement of poorly soluble drugs with mesoporous silicon - p. 469 23. Chapter 18 Silica nanoparticles in clinical trials - p. 491 24. Chapter 19 Mesoporous silica nanoparticles for therapeutic uses: From bench to clinics - p. 507 25. Chapter 20 Future perspectives of mesoporous silica-based nanocarriers in drug delivery - p. 545 26. Index - p. 577
