With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access.
The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape.
Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.
1. Section 1. Introduction and background - p. x 2. 1. The development of the pharmaceutical industry - p. x 3. 2. The nature of disease and the purpose of therapy - p. 18 4. 3. Therapeutic modalities - p. 32 5. Section 2. Drug discovery - p. 42 6. 4. Target selection - p. 42 7. 5. From drug target to drug discovery - p. 55 8. 6. High-throughput screening - p. 64 9. 7. The role of medicinal chemistry in the drug discovery process - p. 90 10. 8. Therapeutic antibodies - p. 107 11. 9. Emerging modalities: Nucleotide-based therapies, cell-based therapies, gene therapy - p. 122 12. 10. Metabolism and pharmacokinetic optimization strategies in drug discovery - p. 133 13. 11. Pharmacology - p. 158 14. 12. Nonclinical safety assessment - p. 173 15. 13. Therapeutic vaccines - p. 185 16. Section 3. Drug development - p. 216 17. 14. An introduction to drug development - p. 216 18. 15. Clinical assessment of safety - p. 223 19. 16. Pharmaceutical development - p. 232 20. 17. Clinical development - p. 244 21. 18. Clinical imaging in drug development - p. 257 22. 19. Intellectual property in drug discovery and development - p. 280 23. 20. Regulatory affairs - p. 288 24. 21. The role of pharmaceutical marketing - p. 308 25. Section 4. Facts and figures - p. 331 26. 22. Drug discovery and development: The future? - p. 331 27. Index - p. 349
With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access.
The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape.
Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry.
1. Section 1. Introduction and background - p. x 2. 1. The development of the pharmaceutical industry - p. x 3. 2. The nature of disease and the purpose of therapy - p. 18 4. 3. Therapeutic modalities - p. 32 5. Section 2. Drug discovery - p. 42 6. 4. Target selection - p. 42 7. 5. From drug target to drug discovery - p. 55 8. 6. High-throughput screening - p. 64 9. 7. The role of medicinal chemistry in the drug discovery process - p. 90 10. 8. Therapeutic antibodies - p. 107 11. 9. Emerging modalities: Nucleotide-based therapies, cell-based therapies, gene therapy - p. 122 12. 10. Metabolism and pharmacokinetic optimization strategies in drug discovery - p. 133 13. 11. Pharmacology - p. 158 14. 12. Nonclinical safety assessment - p. 173 15. 13. Therapeutic vaccines - p. 185 16. Section 3. Drug development - p. 216 17. 14. An introduction to drug development - p. 216 18. 15. Clinical assessment of safety - p. 223 19. 16. Pharmaceutical development - p. 232 20. 17. Clinical development - p. 244 21. 18. Clinical imaging in drug development - p. 257 22. 19. Intellectual property in drug discovery and development - p. 280 23. 20. Regulatory affairs - p. 288 24. 21. The role of pharmaceutical marketing - p. 308 25. Section 4. Facts and figures - p. 331 26. 22. Drug discovery and development: The future? - p. 331 27. Index - p. 349
