For more than 95 years, Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. It is designed to optimize electronic searches that will rapidly take you to exactly the information you are seeking. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.
1. 256. Introduction to Microbial Disease: Pathophysiology and Diagnostics - p. 1833 2. 257. The Human Microbiome - p. 1836 3. 258. Principles of Anti-Infective Therapy - p. 1840 4. 259. Approach to Fever or Suspected Infection in the Normal Host - p. 1845 5. 260. Approach to Fever and Suspected Infection in the Immunocompromised Host - p. 1851 6. 261. Prevention and Control of Health Care–Associated Infections - p. 1862 7. 262. Approach to the Patient with Suspected Enteric Infection - p. 1868 8. 263. Approach to the Patient with Urinary Tract Infection - p. 1873 9. 264. Approach to the Patient with a Sexually Transmitted Infection - p. 1878 10. 265. Approach to the Patient Before and After Travel - p. 1885 11. 266. Antibacterial Chemotherapy - p. 1891 12. 267. Staphylococcal Infections - p. 1903 13. 268. Streptococcus Pneumoniae Pulmonary Infections - p. 1911 14. 269. Nonpneumococcal Streptococcal Infections and Rheumatic Fever - p. 1914 15. 270. Enterococcal Infections - p. 1920 16. 271. Clostridial and Clostridioides Infections - p. 1925 17. 272. Gram-Positive Rod Infections - p. 1931 18. 273. Diseases Caused by Non–Spore-Forming Anaerobic Bacteria - p. 1939 19. 274. Neisseria Meningitidis Infections - p. 1942 20. 275. Neisseria Gonorrhoeae Infections - p. 1947 21. 276. Chancroid - p. 1950 22. 277. Haemophilus and Moraxella Infections - p. 1952 23. 278. Cholera and Other Vibrio Infections - p. 1956 24. 279. Campylobacter Infections - p. 1958 25. 280. Escherichia Coli Enteric Infections - p. 1961 26. 281. Enterobacterales: Non-Enteric Infections and Multidrug Resistance - p. 1965 27. 282. Pseudomonas and Burkholderia Infections - p. 1968 28. 283. Diseases Caused by Acinetobacter and Stenotrophomonas Species - p. 1974 29. 284. Salmonella Infections (Including Enteric Fever) - p. 1976 30. 285. Shigellosis - p. 1980 31. 286. Brucellosis - p. 1984 32. 287. Tularemia and Other Francisella Infections - p. 1985 33. 288. Plague and Other Yersinia Infections - p. 1988 34. 289. Whooping Cough and Other Bordetella Infections - p. 1994 35. 290. Legionella Infections - p. 1997 36. 291. Bartonella Infections - p. 2001 37. 292. Granuloma Inguinale (Donovanosis) - p. 2004 38. 293. Mycoplasma Infections - p. 2005 39. 294. Diseases Caused by Chlamydiae - p. 2010 40. 295. Syphilis and Nonsyphilitic Treponematoses - p. 2015 41. 296. Lyme Disease - p. 2023 42. 297. Relapsing Fever and Other Borrelia Infections - p. 2027 43. 298. Leptospirosis - p. 2029 44. 299. Tuberculosis - p. 2032 45. 300. The Nontuberculous Mycobacteria - p. 2045 46. 301. Leprosy (Hansen Disease) - p. 2048 47. 302. Rickettsial Infections - p. 2055 48. 303. Zoonoses - p. 2064 49. 304. Actinomycosis - p. 2067 50. 305. Whipple Disease - p. 2070 51. 306. Nocardiosis - p. 2073 52. 307. Systemic Antifungal Agents - p. 2075 53. 308. Endemic Mycoses - p. 2081 54. 309. Cryptococcosis - p. 2088 55. 310. Candidiasis - p. 2090 56. 311. Aspergillosis - p. 2094 57. 312. Mucormycosis - p. 2099 58. 313. Pneumocystis Pneumonia - p. 2102 59. 314. Mycetoma and Dematiaceous Fungal Infections - p. 2109 60. 315. Antiparasitic Therapy - p. 2112 61. 316. Malaria - p. 2119 62. 317. African Sleeping Sickness - p. 2124 63. 318. Chagas Disease - p. 2127 64. 319. Leishmaniasis - p. 2131 65. 320. Toxoplasmosis - p. 2137 66. 321. Cryptosporidiosis - p. 2141 67. 322. Giardiasis - p. 2144 68. 323. Amebiasis - p. 2147 69. 324. Babesiosis and Other Protozoan Diseases - p. 2151 70. 325. Cestodes - p. 2158 71. 326. Trematode Infections - p. 2164 72. 327. Nematode Infections - p. 2170 73. 328. Antiviral Therapy (Non-HIV) - p. 2181 74. 329. The Common Cold - p. 2192 75. 330. Respiratory Syncytial Virus and Human Metapneumovirus - p. 2194 76. 331. Parainfluenza Viral Disease - p. 2196 77. 332. Influenza - p. 2199 78. 333. Adenovirus Diseases - p. 2204 79. 334. Pre-2019 Coronaviruses - p. 2206 80. 335. COVID-19: Virology and Pathology - p. 2209 81. 336. COVID-19: Epidemiology, Clinical Manifestations, Diagnosis, Community Prevention, and Prognosis - p. 2214 82. 337. COVID-19 Treatment and Vaccination - p. 2216 83. 338. Measles - p. 2221 84. 339. Rubella (German Measles) - p. 2224 85. 340. Mumps - p. 2226 86. 341. Polyomaviruses - p. 2228 87. 342. Parvovirus - p. 2234 88. 343. Smallpox, Monkeypox, and Other Poxvirus Infections - p. 2237 89. 344. Papillomavirus - p. 2241 90. 345. Herpes Simplex Virus Infections - p. 2245 91. 346. Varicella-Zoster Virus (Chickenpox, Shingles) - p. 2248 92. 347. Cytomegalovirus - p. 2251 93. 348. Epstein-Barr Virus Infection - p. 2254 94. 349. Enteroviruses - p. 2257 95. 350. Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses - p. 2262 96. 351. Viral Hemorrhagic Fevers - p. 2265 97. 352. Arboviruses Causing Fever, Rash, and Neurologic Syndromes - p. 2275 98. Section XXV. Retroviruses - p. 2284.e1 99. XXV. RETROVIRUSES - p. 2285 100. 353. Epidemiology and Diagnosis of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. 2286 101. 354. Pathobiology of Human Immunodeficiency Viruses - p. 2291 102. 355. Acute Clinical Manifestations and Diagnosis of HIV - p. 2295 103. 356. Prevention of Human Immunodeficiency Virus Infection - p. 2298 104. 357. Antiretroviral Treatment of Human Immunodeficiency Virus Infection - p. 2300 105. 358. Microbial Complications of HIV/AIDS - p. 2305 106. 359. Systemic Manifestations of HIV/AIDS - p. 2312 107. 360. Retroviruses Other Than Human Immunodeficiency Virus - p. 2324 108. Section XXVI. Behavioral Medicine - p. 2328.e1 109. XXVI. BEHAVIORAL MEDICINE - p. 2329 110. 361. Delirium and Changes in Mental Status - p. 2330 111. 362. Psychiatric Disorders in Medical Practice - p. 2336 112. 363. Nicotine and Tobacco - p. 2349 113. 364. Alcohol Use Disorders - p. 2353 114. 365. Drug Use Disorders - p. 2360 115. Section XXVII. Neurology - p. 2365.e1 116. XXVII. NEUROLOGY - p. 2367 117. 366. Approach to the Patient with Neurologic Disease - p. 2368 118. 367. Headaches and Other Head Pain - p. 2376 119. 368. Traumatic Brain Injury and Spinal Cord Injury - p. 2385 120. 369. Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord - p. 2392 121. 370. Regional Cerebral Dysfunction: Higher Mental Functions - p. 2407 122. 371. Cognitive Impairment and Dementia - p. 2412 123. 372. The Epilepsies - p. 2425 124. 373. Coma, Disorders of Consciousness, and Brain Death - p. 2437 125. 374. Sleep Disorders - p. 2443 126. 375. Approach to Cerebrovascular Diseases - p. 2454 127. 376. Ischemic Cerebrovascular Disease - p. 2464 128. 377. Hemorrhagic Cerebrovascular Disease - p. 2476 129. 378. Parkinsonism - p. 2485 130. 379. Other Movement Disorders - p. 2491 131. 380. Multiple Sclerosis and Demyelinating Conditions - p. 2500 132. 381. Meningitis: Bacterial, Viral, and Other - p. 2512 133. 382. Brain Abscess and Parameningeal Infections - p. 2527 134. 383. Encephalitis - p. 2533 135. 384. Nutritional and Alcohol-Related Neurologic Disorders - p. 2539 136. 385. Developmental and Neurocutaneous Disorders - p. 2547 137. 386. Autonomic Disorders - p. 2555 138. 387. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases - p. 2563 139. 388. Peripheral Neuropathies - p. 2568 140. 389. Muscle Diseases - p. 2582 141. 390. Disorders of Neuromuscular Transmission - p. 2590 142. Section XXVIII. Eye, Ear, Nose, and Throat Diseases - p. 2593.e1 143. XXVIII. EYE, EAR, NOSE, AND THROAT DISEASES - p. 2595 144. 391. Diseases of the Visual System - p. 2596 145. 392. Neuro-Ophthalmology - p. 2614 146. 393. Diseases of the Mouth and Salivary Glands - p. 2620 147. 394. Approach to the Patient with Nose, Sinus, and Ear Disorders - p. 2627 148. 395. Smell and Taste - p. 2639 149. 396. Hearing and Equilibrium - p. 2641 150. 397. Throat Disorders - p. 2648 151. Section XXIX. Medical Consultation - p. 2653.e1 152. XXIX. MEDICAL CONSULTATION - p. 2655 153. 398. Principles of Medical Consultation - p. 2656 154. 399. Preoperative Evaluation - p. 2659 155. 400. Overview of Anesthesia - p. 2669 156. 401. Postoperative Care and Complications - p. 2673 157. 402. Medical Care of Patients with Psychiatric Diseases - p. 2677 158. Section XXX. Skin Diseases - p. 2684.e1 159. XXX. SKIN DISEASES - p. 2685 160. 403. Approach to Skin Diseases - p. 2686 161. 404. Principles of Therapy of Skin Diseases - p. 2697 162. 405. Eczemas, Photodermatoses, Papulosquamous (Including Fungal) Diseases, and Figurate Erythemas - p. 2702 163. 406. Macular, Papular, Purpuric, Vesiculobullous, and Pustular Diseases - p. 2712 164. 407. Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases - p. 2724 165. 408. Infections, Pigmentation Disorders, Regional Dermatology, and Distinctive Lesions in Black Skin - p. 2738 166. 409. Diseases of Hair and Nails - p. 2747 167. Appendix. Reference Intervals and Laboratory Values - p. e1 168. INDEX - p. I-1 169. IBC - p. ES1
For more than 95 years, Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. It is designed to optimize electronic searches that will rapidly take you to exactly the information you are seeking. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information.
1. 256. Introduction to Microbial Disease: Pathophysiology and Diagnostics - p. 1833 2. 257. The Human Microbiome - p. 1836 3. 258. Principles of Anti-Infective Therapy - p. 1840 4. 259. Approach to Fever or Suspected Infection in the Normal Host - p. 1845 5. 260. Approach to Fever and Suspected Infection in the Immunocompromised Host - p. 1851 6. 261. Prevention and Control of Health Care–Associated Infections - p. 1862 7. 262. Approach to the Patient with Suspected Enteric Infection - p. 1868 8. 263. Approach to the Patient with Urinary Tract Infection - p. 1873 9. 264. Approach to the Patient with a Sexually Transmitted Infection - p. 1878 10. 265. Approach to the Patient Before and After Travel - p. 1885 11. 266. Antibacterial Chemotherapy - p. 1891 12. 267. Staphylococcal Infections - p. 1903 13. 268. Streptococcus Pneumoniae Pulmonary Infections - p. 1911 14. 269. Nonpneumococcal Streptococcal Infections and Rheumatic Fever - p. 1914 15. 270. Enterococcal Infections - p. 1920 16. 271. Clostridial and Clostridioides Infections - p. 1925 17. 272. Gram-Positive Rod Infections - p. 1931 18. 273. Diseases Caused by Non–Spore-Forming Anaerobic Bacteria - p. 1939 19. 274. Neisseria Meningitidis Infections - p. 1942 20. 275. Neisseria Gonorrhoeae Infections - p. 1947 21. 276. Chancroid - p. 1950 22. 277. Haemophilus and Moraxella Infections - p. 1952 23. 278. Cholera and Other Vibrio Infections - p. 1956 24. 279. Campylobacter Infections - p. 1958 25. 280. Escherichia Coli Enteric Infections - p. 1961 26. 281. Enterobacterales: Non-Enteric Infections and Multidrug Resistance - p. 1965 27. 282. Pseudomonas and Burkholderia Infections - p. 1968 28. 283. Diseases Caused by Acinetobacter and Stenotrophomonas Species - p. 1974 29. 284. Salmonella Infections (Including Enteric Fever) - p. 1976 30. 285. Shigellosis - p. 1980 31. 286. Brucellosis - p. 1984 32. 287. Tularemia and Other Francisella Infections - p. 1985 33. 288. Plague and Other Yersinia Infections - p. 1988 34. 289. Whooping Cough and Other Bordetella Infections - p. 1994 35. 290. Legionella Infections - p. 1997 36. 291. Bartonella Infections - p. 2001 37. 292. Granuloma Inguinale (Donovanosis) - p. 2004 38. 293. Mycoplasma Infections - p. 2005 39. 294. Diseases Caused by Chlamydiae - p. 2010 40. 295. Syphilis and Nonsyphilitic Treponematoses - p. 2015 41. 296. Lyme Disease - p. 2023 42. 297. Relapsing Fever and Other Borrelia Infections - p. 2027 43. 298. Leptospirosis - p. 2029 44. 299. Tuberculosis - p. 2032 45. 300. The Nontuberculous Mycobacteria - p. 2045 46. 301. Leprosy (Hansen Disease) - p. 2048 47. 302. Rickettsial Infections - p. 2055 48. 303. Zoonoses - p. 2064 49. 304. Actinomycosis - p. 2067 50. 305. Whipple Disease - p. 2070 51. 306. Nocardiosis - p. 2073 52. 307. Systemic Antifungal Agents - p. 2075 53. 308. Endemic Mycoses - p. 2081 54. 309. Cryptococcosis - p. 2088 55. 310. Candidiasis - p. 2090 56. 311. Aspergillosis - p. 2094 57. 312. Mucormycosis - p. 2099 58. 313. Pneumocystis Pneumonia - p. 2102 59. 314. Mycetoma and Dematiaceous Fungal Infections - p. 2109 60. 315. Antiparasitic Therapy - p. 2112 61. 316. Malaria - p. 2119 62. 317. African Sleeping Sickness - p. 2124 63. 318. Chagas Disease - p. 2127 64. 319. Leishmaniasis - p. 2131 65. 320. Toxoplasmosis - p. 2137 66. 321. Cryptosporidiosis - p. 2141 67. 322. Giardiasis - p. 2144 68. 323. Amebiasis - p. 2147 69. 324. Babesiosis and Other Protozoan Diseases - p. 2151 70. 325. Cestodes - p. 2158 71. 326. Trematode Infections - p. 2164 72. 327. Nematode Infections - p. 2170 73. 328. Antiviral Therapy (Non-HIV) - p. 2181 74. 329. The Common Cold - p. 2192 75. 330. Respiratory Syncytial Virus and Human Metapneumovirus - p. 2194 76. 331. Parainfluenza Viral Disease - p. 2196 77. 332. Influenza - p. 2199 78. 333. Adenovirus Diseases - p. 2204 79. 334. Pre-2019 Coronaviruses - p. 2206 80. 335. COVID-19: Virology and Pathology - p. 2209 81. 336. COVID-19: Epidemiology, Clinical Manifestations, Diagnosis, Community Prevention, and Prognosis - p. 2214 82. 337. COVID-19 Treatment and Vaccination - p. 2216 83. 338. Measles - p. 2221 84. 339. Rubella (German Measles) - p. 2224 85. 340. Mumps - p. 2226 86. 341. Polyomaviruses - p. 2228 87. 342. Parvovirus - p. 2234 88. 343. Smallpox, Monkeypox, and Other Poxvirus Infections - p. 2237 89. 344. Papillomavirus - p. 2241 90. 345. Herpes Simplex Virus Infections - p. 2245 91. 346. Varicella-Zoster Virus (Chickenpox, Shingles) - p. 2248 92. 347. Cytomegalovirus - p. 2251 93. 348. Epstein-Barr Virus Infection - p. 2254 94. 349. Enteroviruses - p. 2257 95. 350. Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses - p. 2262 96. 351. Viral Hemorrhagic Fevers - p. 2265 97. 352. Arboviruses Causing Fever, Rash, and Neurologic Syndromes - p. 2275 98. Section XXV. Retroviruses - p. 2284.e1 99. XXV. RETROVIRUSES - p. 2285 100. 353. Epidemiology and Diagnosis of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. 2286 101. 354. Pathobiology of Human Immunodeficiency Viruses - p. 2291 102. 355. Acute Clinical Manifestations and Diagnosis of HIV - p. 2295 103. 356. Prevention of Human Immunodeficiency Virus Infection - p. 2298 104. 357. Antiretroviral Treatment of Human Immunodeficiency Virus Infection - p. 2300 105. 358. Microbial Complications of HIV/AIDS - p. 2305 106. 359. Systemic Manifestations of HIV/AIDS - p. 2312 107. 360. Retroviruses Other Than Human Immunodeficiency Virus - p. 2324 108. Section XXVI. Behavioral Medicine - p. 2328.e1 109. XXVI. BEHAVIORAL MEDICINE - p. 2329 110. 361. Delirium and Changes in Mental Status - p. 2330 111. 362. Psychiatric Disorders in Medical Practice - p. 2336 112. 363. Nicotine and Tobacco - p. 2349 113. 364. Alcohol Use Disorders - p. 2353 114. 365. Drug Use Disorders - p. 2360 115. Section XXVII. Neurology - p. 2365.e1 116. XXVII. NEUROLOGY - p. 2367 117. 366. Approach to the Patient with Neurologic Disease - p. 2368 118. 367. Headaches and Other Head Pain - p. 2376 119. 368. Traumatic Brain Injury and Spinal Cord Injury - p. 2385 120. 369. Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord - p. 2392 121. 370. Regional Cerebral Dysfunction: Higher Mental Functions - p. 2407 122. 371. Cognitive Impairment and Dementia - p. 2412 123. 372. The Epilepsies - p. 2425 124. 373. Coma, Disorders of Consciousness, and Brain Death - p. 2437 125. 374. Sleep Disorders - p. 2443 126. 375. Approach to Cerebrovascular Diseases - p. 2454 127. 376. Ischemic Cerebrovascular Disease - p. 2464 128. 377. Hemorrhagic Cerebrovascular Disease - p. 2476 129. 378. Parkinsonism - p. 2485 130. 379. Other Movement Disorders - p. 2491 131. 380. Multiple Sclerosis and Demyelinating Conditions - p. 2500 132. 381. Meningitis: Bacterial, Viral, and Other - p. 2512 133. 382. Brain Abscess and Parameningeal Infections - p. 2527 134. 383. Encephalitis - p. 2533 135. 384. Nutritional and Alcohol-Related Neurologic Disorders - p. 2539 136. 385. Developmental and Neurocutaneous Disorders - p. 2547 137. 386. Autonomic Disorders - p. 2555 138. 387. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases - p. 2563 139. 388. Peripheral Neuropathies - p. 2568 140. 389. Muscle Diseases - p. 2582 141. 390. Disorders of Neuromuscular Transmission - p. 2590 142. Section XXVIII. Eye, Ear, Nose, and Throat Diseases - p. 2593.e1 143. XXVIII. EYE, EAR, NOSE, AND THROAT DISEASES - p. 2595 144. 391. Diseases of the Visual System - p. 2596 145. 392. Neuro-Ophthalmology - p. 2614 146. 393. Diseases of the Mouth and Salivary Glands - p. 2620 147. 394. Approach to the Patient with Nose, Sinus, and Ear Disorders - p. 2627 148. 395. Smell and Taste - p. 2639 149. 396. Hearing and Equilibrium - p. 2641 150. 397. Throat Disorders - p. 2648 151. Section XXIX. Medical Consultation - p. 2653.e1 152. XXIX. MEDICAL CONSULTATION - p. 2655 153. 398. Principles of Medical Consultation - p. 2656 154. 399. Preoperative Evaluation - p. 2659 155. 400. Overview of Anesthesia - p. 2669 156. 401. Postoperative Care and Complications - p. 2673 157. 402. Medical Care of Patients with Psychiatric Diseases - p. 2677 158. Section XXX. Skin Diseases - p. 2684.e1 159. XXX. SKIN DISEASES - p. 2685 160. 403. Approach to Skin Diseases - p. 2686 161. 404. Principles of Therapy of Skin Diseases - p. 2697 162. 405. Eczemas, Photodermatoses, Papulosquamous (Including Fungal) Diseases, and Figurate Erythemas - p. 2702 163. 406. Macular, Papular, Purpuric, Vesiculobullous, and Pustular Diseases - p. 2712 164. 407. Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases - p. 2724 165. 408. Infections, Pigmentation Disorders, Regional Dermatology, and Distinctive Lesions in Black Skin - p. 2738 166. 409. Diseases of Hair and Nails - p. 2747 167. Appendix. Reference Intervals and Laboratory Values - p. e1 168. INDEX - p. I-1 169. IBC - p. ES1
