Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation.
Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.
1. Protein Kinase Inhibitors - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. Preface - p. Page xi 8. List of Illustrations - p. Page xiii 9. List of Tables - p. Page xiv 10. Chapter 1 : Kinase inhibitors: An overview - p. Page xiv 11. Chapter 2 : Protein kinase inhibitors and cancer targeted therapy - p. Page 15 12. Chapter 3 : Drug discovery for cancer therapy with special reference to inhibitors of protein kinase pathway - p. Page 63 13. Chapter 4 : An insight on PI3K/AKT/MTOR inhibitors in cancer: Opportunity and translational perspectives - p. Page 92 14. Chapter 5 : Recent advances in the therapeutic development of ERK inhibitors - p. Page 125 15. Chapter 6 : Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy - p. Page 171 16. Chapter 7 : Targeting pyruvate kinase M2 signaling for development of effective cancer therapy - p. Page 194 17. Chapter 8 : Serum and glucocorticoid-regulated kinase 1: A potential target for anticancer therapy - p. Page 217 18. Chapter 9 : Akt inhibitors in cancer therapy - p. Page 234 19. Chapter 10 : Aurora kinase: An emerging potential target in therapeutics - p. Page 253 20. Chapter 11 : The retroactive and future potentials of Aurora kinases in the treatment of cancer - p. Page 306 21. Chapter 12 : Targeting the altered tyrosine kinases in colorectal cancer: From inhibitors to drugs - p. Page 352 22. Chapter 13 : PTEN-induced kinase1 (PINK1): More than just mitochondrial quality control - p. Page 385 23. Chapter 14 : ROCKs as a potential drug target to combat Alzheimer's disease - p. Page 403 24. Chapter 15 : Protein kinase inhibitors from discovery to therapeutics - p. Page 427 25. Chapter 16 : Polo-like kinases: An antimitotic drug target for cancer therapy - p. Page 454 26. Chapter 17 : Src kinase: An attractive therapeutic target for prostate cancer - p. Page 476 27. Chapter 18 : Kinase inhibition in Alzheimer’s disease - p. Page 498 28. Chapter 19 : Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseases - p. Page 519 29. Chapter 20 : Microtubule affinity regulating kinase 4: A potential drug target from cancers to neurodegenerative diseases - p. Page 561 30. Chapter 21 : Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potential - p. Page 587 31. Chapter 22 : Therapeutic potential of leucine-rich repeat kinase 2 inhibitors for Parkinson's disease treatment - p. Page 614 32. Chapter 23 : Calcium calmodulin-dependent protein kinase as a potential drug target - p. Page 646 33. Chapter 24 : Therapeutics of platelet-derived growth factor and signaling in different organs - p. Page 667 34. Chapter 25 : EGFRC797S mutation and fourth-generation EGFR tyrosine kinase inhibitors - p. Page 683 35. Chapter 26 : Bacterial histidine kinases as potential antibacterial drug targets - p. Page 704 36. Chapter 27 : Bacterial protein kinases: A target to inhibit the bacterial infections - p. Page 729 37. Chapter 28 : Nanotechnology-based targeted delivery systems for protein kinase inhibitors in Cancer therapy - p. Page 741 38. Index - p. Page 771
Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation.
Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.
1. Protein Kinase Inhibitors - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. Preface - p. Page xi 8. List of Illustrations - p. Page xiii 9. List of Tables - p. Page xiv 10. Chapter 1 : Kinase inhibitors: An overview - p. Page xiv 11. Chapter 2 : Protein kinase inhibitors and cancer targeted therapy - p. Page 15 12. Chapter 3 : Drug discovery for cancer therapy with special reference to inhibitors of protein kinase pathway - p. Page 63 13. Chapter 4 : An insight on PI3K/AKT/MTOR inhibitors in cancer: Opportunity and translational perspectives - p. Page 92 14. Chapter 5 : Recent advances in the therapeutic development of ERK inhibitors - p. Page 125 15. Chapter 6 : Emerging small-molecule inhibitors of ATM kinase targeting cancer therapy - p. Page 171 16. Chapter 7 : Targeting pyruvate kinase M2 signaling for development of effective cancer therapy - p. Page 194 17. Chapter 8 : Serum and glucocorticoid-regulated kinase 1: A potential target for anticancer therapy - p. Page 217 18. Chapter 9 : Akt inhibitors in cancer therapy - p. Page 234 19. Chapter 10 : Aurora kinase: An emerging potential target in therapeutics - p. Page 253 20. Chapter 11 : The retroactive and future potentials of Aurora kinases in the treatment of cancer - p. Page 306 21. Chapter 12 : Targeting the altered tyrosine kinases in colorectal cancer: From inhibitors to drugs - p. Page 352 22. Chapter 13 : PTEN-induced kinase1 (PINK1): More than just mitochondrial quality control - p. Page 385 23. Chapter 14 : ROCKs as a potential drug target to combat Alzheimer's disease - p. Page 403 24. Chapter 15 : Protein kinase inhibitors from discovery to therapeutics - p. Page 427 25. Chapter 16 : Polo-like kinases: An antimitotic drug target for cancer therapy - p. Page 454 26. Chapter 17 : Src kinase: An attractive therapeutic target for prostate cancer - p. Page 476 27. Chapter 18 : Kinase inhibition in Alzheimer’s disease - p. Page 498 28. Chapter 19 : Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseases - p. Page 519 29. Chapter 20 : Microtubule affinity regulating kinase 4: A potential drug target from cancers to neurodegenerative diseases - p. Page 561 30. Chapter 21 : Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potential - p. Page 587 31. Chapter 22 : Therapeutic potential of leucine-rich repeat kinase 2 inhibitors for Parkinson's disease treatment - p. Page 614 32. Chapter 23 : Calcium calmodulin-dependent protein kinase as a potential drug target - p. Page 646 33. Chapter 24 : Therapeutics of platelet-derived growth factor and signaling in different organs - p. Page 667 34. Chapter 25 : EGFRC797S mutation and fourth-generation EGFR tyrosine kinase inhibitors - p. Page 683 35. Chapter 26 : Bacterial histidine kinases as potential antibacterial drug targets - p. Page 704 36. Chapter 27 : Bacterial protein kinases: A target to inhibit the bacterial infections - p. Page 729 37. Chapter 28 : Nanotechnology-based targeted delivery systems for protein kinase inhibitors in Cancer therapy - p. Page 741 38. Index - p. Page 771
