Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.
1. Cover image - p. i 2. Title page - p. iii 3. Table of Contents - p. ii 4. Series Page - p. ii 5. Copyright - p. ii 6. Contributors - p. ii 7. Preface: Pushing the boundaries of cardiovascular research through interdisciplinary approaches, innovative thinking and new technologies - p. ii 8. Chapter One: Macrophage lineages in heart development and regeneration - p. 2 9. Chapter Two: Computational approaches for mechanobiology in cardiovascular development and diseases - p. 20 10. Chapter Three: RNA binding proteins in cardiovascular development and disease - p. 53 11. Abstract - p. 53 12. 1 RNA binding proteins - p. 53 13. 2 Role of RBPs in mRNA life cycle - p. 55 14. 3 RNA binding protein-RNA complexes - p. 59 15. 4 RBPs in heart development - p. 60 16. 5 RBPs in congenital heart defects - p. 61 17. 6 Septation defects with RBP involvement - p. 62 18. 7 Outflow track/blood vessel/valve related congenital heart defects with RBP involvement - p. 63 19. 8 Other congenital heart defects with RBP involvement - p. 66 20. 9 Cardiomyopathy/heart failure with RBP involvement - p. 66 21. 10 Dilated cardiomyopathy - p. 66 22. 11 Complex congenital diseases with RBP involvement - p. 69 23. 12 RBPs in congenital heart diseases - p. 71 24. 13 RBFOX2/RBM9 and RBFOX1/A2BP1 (RNA binding Fox-1 homolog 1 & 2) - p. 71 25. 14 GATA4 (GATA binding protein 4) - p. 77 26. 15 DiGeorge syndrome critical region 8 (DGCR8)/Pasha - p. 78 27. 16 CPSF6: cleavage and polyadenylation specific factor 6 (CFlm68 or CPSF68) - p. 79 28. 17 NONO/ Non-POU domain containing octamer binding - p. 80 29. 18 RBM20/ RNA binding motif protein 20 - p. 81 30. 19 RBM10/RNA binding motif protein 10 - p. 83 31. 20 hnRNPA1/heterogeneous nuclear ribonucleoprotein A1 - p. 84 32. 21 DDX3X/ DEAD-box helicase 3 X-linked - p. 85 33. 22 ADAR/adenosine deaminase RNA specific - p. 87 34. 23 hnRNPU/heterogeneous nuclear ribonucleoprotein U/scaffold attachment factor A (SAF-A) - p. 89 35. 24 PUF60/Poly(U) binding splicing factor 60 - p. 89 36. 25 LRPPRC/leucine rich pentatricopeptide repeat containing/leucine-rich PPR motif-containing protein, mitochondrial - p. 90 37. 26 RBM8A (RNA binding motif protein 8A) - p. 91 38. 27 Ribosomal proteins - p. 92 39. 28 RPL3L/ribosomal protein L3 like - p. 93 40. 29 RBPs associated with congenital heart defects in animal models - p. 94 41. 30 QKI/quaking - p. 95 42. 31 PCBP1/poly(RC) binding protein1/ hnRNPE1/heterogeneous nuclear ribonucleoprotein E1 - p. 96 43. 32 RBPs involved in heart development - p. 97 44. 33 Polypyrimidine tract binding protein 1 - p. 98 45. 34 RNA binding motif protein 15 - p. 99 46. 35 Concluding remarks - p. 99 47. References - p. 119 48. Chapter Four: Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development - p. 122 49. Chapter Five: The cardiac conduction system: History, development, and disease - p. 159 50. Chapter Six: The role of metabolism in cardiac development - p. 202 51. Chapter Seven: The genetics of cardiomyocyte polyploidy - p. 246 52. Chapter Eight: Genetics and etiology of congenital heart disease - p. 298
Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.
1. Cover image - p. i 2. Title page - p. iii 3. Table of Contents - p. ii 4. Series Page - p. ii 5. Copyright - p. ii 6. Contributors - p. ii 7. Preface: Pushing the boundaries of cardiovascular research through interdisciplinary approaches, innovative thinking and new technologies - p. ii 8. Chapter One: Macrophage lineages in heart development and regeneration - p. 2 9. Chapter Two: Computational approaches for mechanobiology in cardiovascular development and diseases - p. 20 10. Chapter Three: RNA binding proteins in cardiovascular development and disease - p. 53 11. Abstract - p. 53 12. 1 RNA binding proteins - p. 53 13. 2 Role of RBPs in mRNA life cycle - p. 55 14. 3 RNA binding protein-RNA complexes - p. 59 15. 4 RBPs in heart development - p. 60 16. 5 RBPs in congenital heart defects - p. 61 17. 6 Septation defects with RBP involvement - p. 62 18. 7 Outflow track/blood vessel/valve related congenital heart defects with RBP involvement - p. 63 19. 8 Other congenital heart defects with RBP involvement - p. 66 20. 9 Cardiomyopathy/heart failure with RBP involvement - p. 66 21. 10 Dilated cardiomyopathy - p. 66 22. 11 Complex congenital diseases with RBP involvement - p. 69 23. 12 RBPs in congenital heart diseases - p. 71 24. 13 RBFOX2/RBM9 and RBFOX1/A2BP1 (RNA binding Fox-1 homolog 1 & 2) - p. 71 25. 14 GATA4 (GATA binding protein 4) - p. 77 26. 15 DiGeorge syndrome critical region 8 (DGCR8)/Pasha - p. 78 27. 16 CPSF6: cleavage and polyadenylation specific factor 6 (CFlm68 or CPSF68) - p. 79 28. 17 NONO/ Non-POU domain containing octamer binding - p. 80 29. 18 RBM20/ RNA binding motif protein 20 - p. 81 30. 19 RBM10/RNA binding motif protein 10 - p. 83 31. 20 hnRNPA1/heterogeneous nuclear ribonucleoprotein A1 - p. 84 32. 21 DDX3X/ DEAD-box helicase 3 X-linked - p. 85 33. 22 ADAR/adenosine deaminase RNA specific - p. 87 34. 23 hnRNPU/heterogeneous nuclear ribonucleoprotein U/scaffold attachment factor A (SAF-A) - p. 89 35. 24 PUF60/Poly(U) binding splicing factor 60 - p. 89 36. 25 LRPPRC/leucine rich pentatricopeptide repeat containing/leucine-rich PPR motif-containing protein, mitochondrial - p. 90 37. 26 RBM8A (RNA binding motif protein 8A) - p. 91 38. 27 Ribosomal proteins - p. 92 39. 28 RPL3L/ribosomal protein L3 like - p. 93 40. 29 RBPs associated with congenital heart defects in animal models - p. 94 41. 30 QKI/quaking - p. 95 42. 31 PCBP1/poly(RC) binding protein1/ hnRNPE1/heterogeneous nuclear ribonucleoprotein E1 - p. 96 43. 32 RBPs involved in heart development - p. 97 44. 33 Polypyrimidine tract binding protein 1 - p. 98 45. 34 RNA binding motif protein 15 - p. 99 46. 35 Concluding remarks - p. 99 47. References - p. 119 48. Chapter Four: Cardiac construction—Recent advances in morphological and transcriptional modeling of early heart development - p. 122 49. Chapter Five: The cardiac conduction system: History, development, and disease - p. 159 50. Chapter Six: The role of metabolism in cardiac development - p. 202 51. Chapter Seven: The genetics of cardiomyocyte polyploidy - p. 246 52. Chapter Eight: Genetics and etiology of congenital heart disease - p. 298
