Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.
1. Hepatic Fibrosis - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Preface - p. Page v 7. Acknowledgments - p. Page vi 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : The healthy and diseased extracellular matrix of the liver - p. Page viii 11. Chapter 2 : From inflammation to fibrosis - p. Page 12 12. Chapter 3 : Cells, cytokines, and factors involved in profibrogenic pathways - p. Page 40 13. Chapter 4 : Role of free radicals in hepatic fibrogenesis - p. Page 70 14. Chapter 5 : Role of gut dysbiosis in chronic liver disease leading to fibrosis - p. Page 93 15. Chapter 6 : Alcohol-induced liver fibrosis - p. Page 114 16. Chapter 7 : From fatty liver to nonalcoholic steatohepatitis with fibrosis - p. Page 137 17. Chapter 8 : Chronic viral hepatitis induced liver fibrosis - p. Page 162 18. Chapter 9 : Fibrosis induced by chronic cholestatic diseases - p. Page 184 19. Chapter 10 : Experimental models of hepatic fibrosis - p. Page 202 20. Chapter 11 : Monitoring of hepatic fibrosis - p. Page 221 21. Index - p. Page 238
Hepatic Fibrosis: Mechanisms and Targets is a complete volume of liver extracellular matrix biology, including molecular signaling pathways, cells and factors that modulate fibrogenesis and fibrosis. The book uses an integrated approach toward the molecular and cellular mechanisms involved in the synthesis and degradation of hepatic fibrotic tissue, emphasizing the possible molecular targets to fight fibrosis. This important reference describes, in detail and didactically, the cellular and molecular events that are conducive to fibrosis that leads to cirrhosis, hepatocellular carcinoma and death. The provided information allows readers to understand the molecular mechanisms of hepatic fibrogenesis to accelerate the development of new therapies.
1. Hepatic Fibrosis - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Preface - p. Page v 7. Acknowledgments - p. Page vi 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : The healthy and diseased extracellular matrix of the liver - p. Page viii 11. Chapter 2 : From inflammation to fibrosis - p. Page 12 12. Chapter 3 : Cells, cytokines, and factors involved in profibrogenic pathways - p. Page 40 13. Chapter 4 : Role of free radicals in hepatic fibrogenesis - p. Page 70 14. Chapter 5 : Role of gut dysbiosis in chronic liver disease leading to fibrosis - p. Page 93 15. Chapter 6 : Alcohol-induced liver fibrosis - p. Page 114 16. Chapter 7 : From fatty liver to nonalcoholic steatohepatitis with fibrosis - p. Page 137 17. Chapter 8 : Chronic viral hepatitis induced liver fibrosis - p. Page 162 18. Chapter 9 : Fibrosis induced by chronic cholestatic diseases - p. Page 184 19. Chapter 10 : Experimental models of hepatic fibrosis - p. Page 202 20. Chapter 11 : Monitoring of hepatic fibrosis - p. Page 221 21. Index - p. Page 238
