Human Papillomavirus: Proving and Using a Viral Cause for Cancer presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine.
1. General Introduction—The Background to Human Papillomavirus and Cancer Research - p. xxv 2. Chapter 1. A Brief History of Cervical Cancer - p. 1 3. Section 1: Proving the Role of Human Papillomavirus in Cervical Cancer: Studies in the Laboratory, Clinic, and Community - p. 11 4. Section 1. Proving the Role of Human Papillomavirus in Cervical Cancer: Studies in the Laboratory, Clinic, and Community - p. 13 5. Chapter 2. Linking Human Papillomavirus to Human Cancer and Understanding Its Carcinogenic Mechanisms - p. 17 6. Chapter 3. Demonstrating the Importance of Different HPVs in Cervical Cancer and Other HPV-Related Cancers - p. 41 7. Chapter 4. Finding How Human Papillomaviruses Alter the Biochemistry and Identity of Infected Epithelial Cells - p. 53 8. Chapter 5. Biology of the Human Papillomavirus Life Cycle: The Basis for Understanding the Pathology of PreCancer and Cancer - p. 67 9. Chapter 6. The Pathology of Cervical Precancer and Cancer and its importance in clinical practice - p. 85 10. Chapter 7. Developing and Standardizing Human Papillomavirus Tests - p. 111 11. Chapter 8. Proving the Causal Role of Human Papillomavirus in Cervical Cancer: A Tale of Multidisciplinary Science - p. 131 12. Chapter 9. The Natural History of Human Papillomavirus Infection in Relation to Cervical Cancer - p. 149 13. Section 2: Human Papillomavirus Beyond Cervical Cancer - p. 156 14. Section 2. Human Papillomavirus Beyond Cervical Cancer - p. 161 15. Chapter 10. Low-risk Human Papillomavirus: Genital Warts, Cancer and Respiratory Papillomatosis - p. 165 16. Chapter 11. Human Papillomavirus Infection and Related Diseases Among Men - p. 179 17. Chapter 12. Anal HPV Infection and HPV-Associated Disease - p. 195 18. Chapter 13. Oropharyngeal Human Papillomavirus and Head and Neck Cancer - p. 205 19. Chapter 14. Vulvar, Penile, and Scrotal Human Papillomavirus and Non–Human Papillomavirus Cancer Pathways - p. 219 20. Section 3: Using Human Papillomavirus Knowledge to Prevent Cervical and Other Cancers - p. 229 21. Section 3. Using Human Papillomavirus Knowledge to Prevent Cervical and Other Cancers - p. 231 22. Chapter 15. Triage of Women With ASCUS and LSIL Abnormal Cytology: The ALTS Experience and Beyond - p. 235 23. Chapter 16. Primary Screening by Human Papillomavirus Testing: Development, Implementation, and Perspectives - p. 245 24. Chapter 17. Infection to Cancer—Finding Useful Biomarkers for Predicting Risk of Progression to Cancer - p. 269 25. Chapter 18. Immune Responses to Human Papillomavirus and the Development of Human Papillomavirus Vaccines - p. 283 26. Chapter 19. Clinical Trials of Human Papillomavirus Vaccines - p. 299 27. Section 4: Accumulating Long-Term Evidence for Global Control and Elimination of Human Papillomavirus Induced Cancers - p. 321 28. Section 4. Accumulating Long-Term Evidence for Global Control and Elimination of Human Papillomavirus Induced Cancers - p. 327 29. Chapter 20. The Key Role of Mathematical Modeling and Health Economics in the Public Health Transitions in Cervical Cancer Prevention - p. 333 30. Chapter 21. Twelve Years of Vaccine Registration and the Consequences - p. 349 31. Chapter 22. Political and Public Responses to Human Papillomavirus Vaccination - p. 363 32. Chapter 23. Expanding Prevention of Cervical Cancer in Low- and Middle-Income Countries - p. 379 33. Epilogue: Looking forward to cervical cancer elimination - p. 389 34. Index - p. 403
Human Papillomavirus: Proving and Using a Viral Cause for Cancer presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine.
1. General Introduction—The Background to Human Papillomavirus and Cancer Research - p. xxv 2. Chapter 1. A Brief History of Cervical Cancer - p. 1 3. Section 1: Proving the Role of Human Papillomavirus in Cervical Cancer: Studies in the Laboratory, Clinic, and Community - p. 11 4. Section 1. Proving the Role of Human Papillomavirus in Cervical Cancer: Studies in the Laboratory, Clinic, and Community - p. 13 5. Chapter 2. Linking Human Papillomavirus to Human Cancer and Understanding Its Carcinogenic Mechanisms - p. 17 6. Chapter 3. Demonstrating the Importance of Different HPVs in Cervical Cancer and Other HPV-Related Cancers - p. 41 7. Chapter 4. Finding How Human Papillomaviruses Alter the Biochemistry and Identity of Infected Epithelial Cells - p. 53 8. Chapter 5. Biology of the Human Papillomavirus Life Cycle: The Basis for Understanding the Pathology of PreCancer and Cancer - p. 67 9. Chapter 6. The Pathology of Cervical Precancer and Cancer and its importance in clinical practice - p. 85 10. Chapter 7. Developing and Standardizing Human Papillomavirus Tests - p. 111 11. Chapter 8. Proving the Causal Role of Human Papillomavirus in Cervical Cancer: A Tale of Multidisciplinary Science - p. 131 12. Chapter 9. The Natural History of Human Papillomavirus Infection in Relation to Cervical Cancer - p. 149 13. Section 2: Human Papillomavirus Beyond Cervical Cancer - p. 156 14. Section 2. Human Papillomavirus Beyond Cervical Cancer - p. 161 15. Chapter 10. Low-risk Human Papillomavirus: Genital Warts, Cancer and Respiratory Papillomatosis - p. 165 16. Chapter 11. Human Papillomavirus Infection and Related Diseases Among Men - p. 179 17. Chapter 12. Anal HPV Infection and HPV-Associated Disease - p. 195 18. Chapter 13. Oropharyngeal Human Papillomavirus and Head and Neck Cancer - p. 205 19. Chapter 14. Vulvar, Penile, and Scrotal Human Papillomavirus and Non–Human Papillomavirus Cancer Pathways - p. 219 20. Section 3: Using Human Papillomavirus Knowledge to Prevent Cervical and Other Cancers - p. 229 21. Section 3. Using Human Papillomavirus Knowledge to Prevent Cervical and Other Cancers - p. 231 22. Chapter 15. Triage of Women With ASCUS and LSIL Abnormal Cytology: The ALTS Experience and Beyond - p. 235 23. Chapter 16. Primary Screening by Human Papillomavirus Testing: Development, Implementation, and Perspectives - p. 245 24. Chapter 17. Infection to Cancer—Finding Useful Biomarkers for Predicting Risk of Progression to Cancer - p. 269 25. Chapter 18. Immune Responses to Human Papillomavirus and the Development of Human Papillomavirus Vaccines - p. 283 26. Chapter 19. Clinical Trials of Human Papillomavirus Vaccines - p. 299 27. Section 4: Accumulating Long-Term Evidence for Global Control and Elimination of Human Papillomavirus Induced Cancers - p. 321 28. Section 4. Accumulating Long-Term Evidence for Global Control and Elimination of Human Papillomavirus Induced Cancers - p. 327 29. Chapter 20. The Key Role of Mathematical Modeling and Health Economics in the Public Health Transitions in Cervical Cancer Prevention - p. 333 30. Chapter 21. Twelve Years of Vaccine Registration and the Consequences - p. 349 31. Chapter 22. Political and Public Responses to Human Papillomavirus Vaccination - p. 363 32. Chapter 23. Expanding Prevention of Cervical Cancer in Low- and Middle-Income Countries - p. 379 33. Epilogue: Looking forward to cervical cancer elimination - p. 389 34. Index - p. 403
