Immunology & Serology in Laboratory Medicine
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Quick Reference - p. i 6. Copyright - p. vi 7. Dedication - p. vii 8. Reviewers - p. viii 9. Preface - p. ix 10. Acknowledgments - p. xii 11. About the Author - p. xiii 12. Part I. Basic Immunologic Mechanisms - p. 1 13. 1. Foundations of Innate and Adaptive Immune Systems - p. 2 14. 2. Soluble Mediators of the Immune System - p. 28 15. 3. Antigens and Antibodies - p. 47 16. 4. Cellular Activities and Clinical Disorders of Innate and Adaptive Immunity - p. 67 17. Part II. The Theory of Immunologic and Serologic Procedures - p. 96.e1 18. 5. Basic Safety in the Immunology-Serology Laboratory - p. 98 19. 6. Basic Quality Control and Quality Assurance Practices - p. 107 20. 7. Basic Serologic Laboratory: Techniques and Clinical Applications - p. 117 21. 8. Precipitation and Particle Agglutination Methods - p. 128 22. 9. Electrophoresis Techniques and Chromatography - p. 143 23. 10. Labeling Techniques in Immunoassay - p. 150 24. 11. Flow Cytometry - p. 159 25. 12. Molecular Laboratory Techniques - p. 168 26. Part III. Immunologic Manifestations of Infectious Diseases - p. 187.e1 27. 13. Infectious Diseases: Overview and TORCH Diseases - p. 190 28. 14. Streptococcal Infections - p. 221 29. 15. Syphilis - p. 228 30. 16. Vector-Borne Diseases - p. 240 31. 17. Infectious Mononucleosis - p. 267 32. 18. Viral Hepatitis - p. 273 33. Part IV. Immune Disorders - p. 297.e1 34. 19. Primary and Acquired Immunodeficiency Syndromes - p. 300 35. Primary Immunodeficiency Disorders - p. 302 36. Characteristics of Primary Immunodeficiency Disorders - p. 304 37. General Laboratory Evaluation - p. 304 38. T-Cell Immunodeficiency Disorders - p. 306 39. Digeorge Syndrome - p. 307 40. Severe Combined Immunodeficiency (SCID) - p. 307 41. Chronic Mucocutaneous Candidiasis - p. 308 42. Bruton X-Linked Agammaglobulinemia (XLA) - p. 309 43. Immunologic Manifestations - p. 310 44. Common Variable Immunodeficiency - p. 310 45. Transient Hypogammaglobulinemia of Infancy - p. 311 46. Immunodeficiency With Elevated Immunoglobulin M (Hyper-IgM) - p. 311 47. Selective Immunoglobulin A Deficiency - p. 311 48. Hyper-E Syndrome (HIES) - p. 311 49. X-Linked Lymphoproliferative Disease (XLP) Syndromes 1 and 2 (Duncan Disease) - p. 312 50. Combined Cellular Immunodeficiency Disorders - p. 312 51. Partial Combined Immune Deficiency Disorders - p. 312 52. Other Primary Immune Disorders - p. 313 53. Acquired (Secondary) Immunodeficiency Disorders - p. 313 54. Acquired Immunodeficiency Syndrome - p. 313 55. Viral Characteristics - p. 314 56. Viral Structure - p. 314 57. Viral Replication - p. 315 58. Epidemiology - p. 316 59. Infectious Patterns - p. 317 60. Modes of Transmission - p. 318 61. Signs and Symptoms - p. 318 62. Opportunistic Infections - p. 319 63. Disease Progression - p. 321 64. Immunologic Manifestations - p. 321 65. Serologic Markers - p. 322 66. Diagnostic Evaluation and Monitoring - p. 322 67. Testing Methods - p. 322 68. HIV-1 Antibody Assays - p. 322 69. HIV Antigen and Genome Testing - p. 324 70. Alternative Screening for HIV - p. 324 71. Fourth-Generation Testing - p. 326 72. Pediatric Testing - p. 326 73. Rapid Testing - p. 326 74. Tests for Therapeutic Monitoring - p. 326 75. Prevention - p. 326 76. Treatment - p. 326 77. Drug Therapy - p. 327 78. Actions of Mechanistic Classes of Antiretroviral Drugs - p. 328 79. Investigational Drugs - p. 331 80. Preexposure and Postexposure Prophylaxis - p. 332 81. 20. Hypersensitivity Reactions - p. 337 82. 21. Plasma Cell Neoplasms and Other Diseases With Paraproteins - p. 353 83. 22. Tolerance, Autoimmunity, and Autoimmune Disorders - p. 369 84. 23. Systemic Lupus Erythematosus - p. 396 85. 24. Rheumatoid Arthritis - p. 414 86. Part V. Transplantation and Tumor Immunology - p. 425.e1 87. 25. Transplantation: Human Leukocyte Antigens, Solid Organ, Tissues, and Hematopoietic Stem Cells - p. 428 88. 26. Tumor Immunology and Applications of Massive Parallel Sequencing/Next-Generation Sequencing - p. 454 89. Part VI. Vaccines - p. 476.e1 90. 27. Vaccines: Development and Applications - p. 478 91. Appendix A. Answers to Case Study Multiple-Choice Questions - p. 500 92. Appendix B. Answers to Review Questions - p. 503 93. Appendix C. Origin and Immunoregulatory Activity of Cytokines - p. 510 94. Appendix D. Coronavirus Disease 2019 (COVID-19) - p. 514 95. Appendix E. Vaccines Licensed for Use in the United States by the Federal Drug Administration - p. 516 96. Bibliography - p. 518 97. Glossary - p. 528 98. Index - p. 550
Immunology & Serology in Laboratory Medicine
1. Title of Book - p. ii 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. ii 5. Quick Reference - p. i 6. Copyright - p. vi 7. Dedication - p. vii 8. Reviewers - p. viii 9. Preface - p. ix 10. Acknowledgments - p. xii 11. About the Author - p. xiii 12. Part I. Basic Immunologic Mechanisms - p. 1 13. 1. Foundations of Innate and Adaptive Immune Systems - p. 2 14. 2. Soluble Mediators of the Immune System - p. 28 15. 3. Antigens and Antibodies - p. 47 16. 4. Cellular Activities and Clinical Disorders of Innate and Adaptive Immunity - p. 67 17. Part II. The Theory of Immunologic and Serologic Procedures - p. 96.e1 18. 5. Basic Safety in the Immunology-Serology Laboratory - p. 98 19. 6. Basic Quality Control and Quality Assurance Practices - p. 107 20. 7. Basic Serologic Laboratory: Techniques and Clinical Applications - p. 117 21. 8. Precipitation and Particle Agglutination Methods - p. 128 22. 9. Electrophoresis Techniques and Chromatography - p. 143 23. 10. Labeling Techniques in Immunoassay - p. 150 24. 11. Flow Cytometry - p. 159 25. 12. Molecular Laboratory Techniques - p. 168 26. Part III. Immunologic Manifestations of Infectious Diseases - p. 187.e1 27. 13. Infectious Diseases: Overview and TORCH Diseases - p. 190 28. 14. Streptococcal Infections - p. 221 29. 15. Syphilis - p. 228 30. 16. Vector-Borne Diseases - p. 240 31. 17. Infectious Mononucleosis - p. 267 32. 18. Viral Hepatitis - p. 273 33. Part IV. Immune Disorders - p. 297.e1 34. 19. Primary and Acquired Immunodeficiency Syndromes - p. 300 35. Primary Immunodeficiency Disorders - p. 302 36. Characteristics of Primary Immunodeficiency Disorders - p. 304 37. General Laboratory Evaluation - p. 304 38. T-Cell Immunodeficiency Disorders - p. 306 39. Digeorge Syndrome - p. 307 40. Severe Combined Immunodeficiency (SCID) - p. 307 41. Chronic Mucocutaneous Candidiasis - p. 308 42. Bruton X-Linked Agammaglobulinemia (XLA) - p. 309 43. Immunologic Manifestations - p. 310 44. Common Variable Immunodeficiency - p. 310 45. Transient Hypogammaglobulinemia of Infancy - p. 311 46. Immunodeficiency With Elevated Immunoglobulin M (Hyper-IgM) - p. 311 47. Selective Immunoglobulin A Deficiency - p. 311 48. Hyper-E Syndrome (HIES) - p. 311 49. X-Linked Lymphoproliferative Disease (XLP) Syndromes 1 and 2 (Duncan Disease) - p. 312 50. Combined Cellular Immunodeficiency Disorders - p. 312 51. Partial Combined Immune Deficiency Disorders - p. 312 52. Other Primary Immune Disorders - p. 313 53. Acquired (Secondary) Immunodeficiency Disorders - p. 313 54. Acquired Immunodeficiency Syndrome - p. 313 55. Viral Characteristics - p. 314 56. Viral Structure - p. 314 57. Viral Replication - p. 315 58. Epidemiology - p. 316 59. Infectious Patterns - p. 317 60. Modes of Transmission - p. 318 61. Signs and Symptoms - p. 318 62. Opportunistic Infections - p. 319 63. Disease Progression - p. 321 64. Immunologic Manifestations - p. 321 65. Serologic Markers - p. 322 66. Diagnostic Evaluation and Monitoring - p. 322 67. Testing Methods - p. 322 68. HIV-1 Antibody Assays - p. 322 69. HIV Antigen and Genome Testing - p. 324 70. Alternative Screening for HIV - p. 324 71. Fourth-Generation Testing - p. 326 72. Pediatric Testing - p. 326 73. Rapid Testing - p. 326 74. Tests for Therapeutic Monitoring - p. 326 75. Prevention - p. 326 76. Treatment - p. 326 77. Drug Therapy - p. 327 78. Actions of Mechanistic Classes of Antiretroviral Drugs - p. 328 79. Investigational Drugs - p. 331 80. Preexposure and Postexposure Prophylaxis - p. 332 81. 20. Hypersensitivity Reactions - p. 337 82. 21. Plasma Cell Neoplasms and Other Diseases With Paraproteins - p. 353 83. 22. Tolerance, Autoimmunity, and Autoimmune Disorders - p. 369 84. 23. Systemic Lupus Erythematosus - p. 396 85. 24. Rheumatoid Arthritis - p. 414 86. Part V. Transplantation and Tumor Immunology - p. 425.e1 87. 25. Transplantation: Human Leukocyte Antigens, Solid Organ, Tissues, and Hematopoietic Stem Cells - p. 428 88. 26. Tumor Immunology and Applications of Massive Parallel Sequencing/Next-Generation Sequencing - p. 454 89. Part VI. Vaccines - p. 476.e1 90. 27. Vaccines: Development and Applications - p. 478 91. Appendix A. Answers to Case Study Multiple-Choice Questions - p. 500 92. Appendix B. Answers to Review Questions - p. 503 93. Appendix C. Origin and Immunoregulatory Activity of Cytokines - p. 510 94. Appendix D. Coronavirus Disease 2019 (COVID-19) - p. 514 95. Appendix E. Vaccines Licensed for Use in the United States by the Federal Drug Administration - p. 516 96. Bibliography - p. 518 97. Glossary - p. 528 98. Index - p. 550
