A must-have resource for all members of the transplant team, Kidney Transplantation: Principles and Practice, 9th Edition, provides comprehensive, up-to-date information on every aspect of this complex field. Drs. Stuart J. Knechtle and Lorna P. Marson, along with a global team of internationally renowned surgeons and nephrologists, offer balanced coverage of both surgical techniques and medical considerations related to kidney transplantation. With updates from cover to cover, this core reference delivers the practical guidance you need to achieve optimal outcomes in both adults and children.
New chapter on xenotransplantation. This area is under active clinical investigation now and it seems likely to move forward in the next few years.
1. Introduction - p. 10 2. Activation of the Immune System Peri-Transplant - p. 11 3. Stimulation of Adaptive Alloimmunity - p. 17 4. T Cell–Mediated Rejection - p. 22 5. B-Cell Activation and Antibody-Mediated Rejection - p. 23 6. Transplant Tolerance - p. 28 7. Conclusion - p. 30 8. References - p. 30 9. 3. Chronic Kidney Failure: Renal Replacement Therapy - p. 40 10. 4. The Recipient of a Renal Transplant - p. 55 11. 5. Access for Renal Replacement Therapy - p. 76 12. 6. Brain Death and Cardiac Death: Donor Criteria and Care of Deceased Donor - p. 101 13. 7. Medical Evaluation of the Living Donor - p. 116 14. 8. Donor Nephrectomy - p. 128 15. 9. Kidney Preservation - p. 140 16. 10. Histocompatability in Kidney Transplantation - p. 150 17. 11. Surgical Techniques of Kidney Transplantation - p. 171 18. 12. Urological Complications After Kidney Transplant and Transplantation Into an Abnormal Bladder - p. 188 19. 13. Perioperative Care of Patients Undergoing Kidney Transplantation - p. 201 20. 14. Early Course of the Patient With a Kidney Transplant - p. 215 21. 15. Azathioprine and Mycophenolates - p. 229 22. 16. Steroids - p. 249 23. 17. Calcineurin Inhibitors - p. 261 24. 18. mTOR Inhibitors: Sirolimus and Everolimus - p. 277 25. 19. Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins - p. 302 26. CHAPTER OUTLINE - p. 302 27. Introduction - p. 302 28. Historical Perspective - p. 303 29. Antibody Structure and Function - p. 304 30. Fusion Protein Structure and Function - p. 304 31. General Clinical Considerations for the Use of Antibody and Fusion Protein Preparations - p. 305 32. Polyclonal Antibody Preparations - p. 306 33. Specific Clinical Applications of Polyclonal Antibody Preparations - p. 307 34. Monoclonal Antibody and Fusion Protein Preparations - p. 309 35. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Practice - p. 309 36. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Investigation - p. 315 37. Conclusions - p. 319 38. References - p. 320 39. 20. Other Forms of Immunosuppression - p. 330 40. CHAPTER OUTLINE - p. 330 41. Small Molecules - p. 330 42. Total Lymphoid Irradiation - p. 341 43. Photopheresis - p. 342 44. Splenectomy - p. 343 45. Plasmapheresis - p. 343 46. References - p. 344 47. 21. Approaches to the Induction of Tolerance - p. 353 48. 22. Transplantation in the Sensitized Recipient and Across ABO Blood Groups - p. 374 49. 23. Paired Exchange Programs for Living Donors - p. 388 50. 24. Kidney Allocation - p. 395 51. 25. Pathology of Kidney Transplantation - p. 407 52. CHAPTER OUTLINE - p. 407 53. Abbreviations [selected] - p. 407 54. Kidney Allograft Biopsy - p. 408 55. Donor Kidney Biopsy - p. 408 56. Hyperacute Rejection - p. 410 57. Acute Kidney Allograft Rejection - p. 410 58. Late Graft Diseases - p. 421 59. Protocol Biopsies - p. 425 60. Acute Tubular Necrosis - p. 426 61. Calcineurin Inhibitor Nephrotoxicity - p. 426 62. Target of Rapamycin Inhibitor Toxicity - p. 429 63. Drug-Induced Acute Tubulointerstitial Nephritis - p. 429 64. Infections - p. 430 65. Major Kidney Vascular Disease - p. 431 66. De Novo Glomerular Disease - p. 431 67. Recurrent Kidney Disease - p. 433 68. Posttransplant Malignancy and Posttransplant Lymphoproliferative Disease/Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency and Dysregulation - p. 433 69. Future Directions in Biopsy Assessment - p. 435 70. Acknowledgments - p. 436 71. References - p. 436 72. 26. Biomarkers for Posttransplant Allograft Monitoring - p. 449 73. 27. Chronic Allograft Failure - p. 461 74. 28. Vascular and Lymphatic Complications After Kidney Transplantation - p. 486 75. 29. Cardiovascular Disease in Renal Transplantation - p. 516 76. 30. Infection in Kidney Transplant Recipients - p. 540 77. CHAPTER OUTLINE - p. 540 78. Overview - p. 540 79. Risk of Infection - p. 540 80. Timeline of Infection - p. 544 81. Assessment of Infectious Diseases in Recipients and Potential Donors Before Transplantation - p. 548 82. Selected Infections of Importance - p. 551 83. Conclusions - p. 561 84. References - p. 561 85. 31. Transplantation in a Pandemic: Lessons Learned From COVID-19 - p. 568 86. 32. Liver Disease Among Renal Transplant Recipients - p. 578 87. CHAPTER OUTLINE - p. 578 88. Overview of Incidence and Clinicopathological Associations - p. 578 89. Combined Liver and Kidney Diseases - p. 579 90. Specific Immunosuppressive Agents in Renal Transplantation and Hepatotoxicity - p. 581 91. Hepatitis Viruses Associated With Renal Transplantation - p. 582 92. Nonalcoholic Fatty Liver Disease and Renal Transplant - p. 595 93. Hepatocellular Carcinoma After Renal Transplantation - p. 597 94. Systemic Infections Resulting in Hepatitis and Liver Disease - p. 598 95. References - p. 600 96. 33. Neurological Complications After Kidney Transplantation - p. 607 97. 34. Cutaneous Disease in Kidney Transplantation Patients - p. 621 98. 35. Cancer in Kidney Failure and Kidney Transplantation - p. 636 99. 36. Pancreas and Kidney Transplantation for Diabetic Nephropathy - p. 653 100. 37. Kidney Transplantation in Children - p. 679 101. CHAPTER OUTLINE - p. 679 102. Introduction - p. 679 103. Epidemiology of End-Stage Kidney Disease in Children - p. 680 104. Access to Transplantation - p. 681 105. Timing of Transplantation - p. 684 106. Patient and Graft Survival - p. 684 107. Contraindications to Transplantation - p. 688 108. Recurrence of Original Disease - p. 688 109. Pretransplant Evaluation - p. 695 110. Perioperative Management of Pediatric Renal Transplant Recipients - p. 699 111. Immunosuppressive Protocols and Drugs - p. 700 112. Acute Rejection in Pediatric Transplantation - p. 705 113. Long-Term Management Posttransplant - p. 707 114. References - p. 710 115. 38. Advancing Kidney Transplantation in Low- and Middle-Income Countries: Challenges and Strategies - p. 721 116. 39. Results of Kidney Transplantation - p. 733 117. 40. Psychosocial Aspects of Kidney Transplantation and Living Kidney Donation - p. 760 118. 41. Ethical and Legal Aspects of Kidney Donation - p. 775 119. 42. Xenotransplantation - p. 791 120. 43. Evidence in Transplantation - p. 803 121. Index - p. 813
A must-have resource for all members of the transplant team, Kidney Transplantation: Principles and Practice, 9th Edition, provides comprehensive, up-to-date information on every aspect of this complex field. Drs. Stuart J. Knechtle and Lorna P. Marson, along with a global team of internationally renowned surgeons and nephrologists, offer balanced coverage of both surgical techniques and medical considerations related to kidney transplantation. With updates from cover to cover, this core reference delivers the practical guidance you need to achieve optimal outcomes in both adults and children.
New chapter on xenotransplantation. This area is under active clinical investigation now and it seems likely to move forward in the next few years.
1. Introduction - p. 10 2. Activation of the Immune System Peri-Transplant - p. 11 3. Stimulation of Adaptive Alloimmunity - p. 17 4. T Cell–Mediated Rejection - p. 22 5. B-Cell Activation and Antibody-Mediated Rejection - p. 23 6. Transplant Tolerance - p. 28 7. Conclusion - p. 30 8. References - p. 30 9. 3. Chronic Kidney Failure: Renal Replacement Therapy - p. 40 10. 4. The Recipient of a Renal Transplant - p. 55 11. 5. Access for Renal Replacement Therapy - p. 76 12. 6. Brain Death and Cardiac Death: Donor Criteria and Care of Deceased Donor - p. 101 13. 7. Medical Evaluation of the Living Donor - p. 116 14. 8. Donor Nephrectomy - p. 128 15. 9. Kidney Preservation - p. 140 16. 10. Histocompatability in Kidney Transplantation - p. 150 17. 11. Surgical Techniques of Kidney Transplantation - p. 171 18. 12. Urological Complications After Kidney Transplant and Transplantation Into an Abnormal Bladder - p. 188 19. 13. Perioperative Care of Patients Undergoing Kidney Transplantation - p. 201 20. 14. Early Course of the Patient With a Kidney Transplant - p. 215 21. 15. Azathioprine and Mycophenolates - p. 229 22. 16. Steroids - p. 249 23. 17. Calcineurin Inhibitors - p. 261 24. 18. mTOR Inhibitors: Sirolimus and Everolimus - p. 277 25. 19. Antilymphocyte Globulin, Monoclonal Antibodies, and Fusion Proteins - p. 302 26. CHAPTER OUTLINE - p. 302 27. Introduction - p. 302 28. Historical Perspective - p. 303 29. Antibody Structure and Function - p. 304 30. Fusion Protein Structure and Function - p. 304 31. General Clinical Considerations for the Use of Antibody and Fusion Protein Preparations - p. 305 32. Polyclonal Antibody Preparations - p. 306 33. Specific Clinical Applications of Polyclonal Antibody Preparations - p. 307 34. Monoclonal Antibody and Fusion Protein Preparations - p. 309 35. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Practice - p. 309 36. Monoclonal Antibodies and Fusion Proteins in Clinical Transplantation Investigation - p. 315 37. Conclusions - p. 319 38. References - p. 320 39. 20. Other Forms of Immunosuppression - p. 330 40. CHAPTER OUTLINE - p. 330 41. Small Molecules - p. 330 42. Total Lymphoid Irradiation - p. 341 43. Photopheresis - p. 342 44. Splenectomy - p. 343 45. Plasmapheresis - p. 343 46. References - p. 344 47. 21. Approaches to the Induction of Tolerance - p. 353 48. 22. Transplantation in the Sensitized Recipient and Across ABO Blood Groups - p. 374 49. 23. Paired Exchange Programs for Living Donors - p. 388 50. 24. Kidney Allocation - p. 395 51. 25. Pathology of Kidney Transplantation - p. 407 52. CHAPTER OUTLINE - p. 407 53. Abbreviations [selected] - p. 407 54. Kidney Allograft Biopsy - p. 408 55. Donor Kidney Biopsy - p. 408 56. Hyperacute Rejection - p. 410 57. Acute Kidney Allograft Rejection - p. 410 58. Late Graft Diseases - p. 421 59. Protocol Biopsies - p. 425 60. Acute Tubular Necrosis - p. 426 61. Calcineurin Inhibitor Nephrotoxicity - p. 426 62. Target of Rapamycin Inhibitor Toxicity - p. 429 63. Drug-Induced Acute Tubulointerstitial Nephritis - p. 429 64. Infections - p. 430 65. Major Kidney Vascular Disease - p. 431 66. De Novo Glomerular Disease - p. 431 67. Recurrent Kidney Disease - p. 433 68. Posttransplant Malignancy and Posttransplant Lymphoproliferative Disease/Lymphoid Proliferations and Lymphomas Associated With Immune Deficiency and Dysregulation - p. 433 69. Future Directions in Biopsy Assessment - p. 435 70. Acknowledgments - p. 436 71. References - p. 436 72. 26. Biomarkers for Posttransplant Allograft Monitoring - p. 449 73. 27. Chronic Allograft Failure - p. 461 74. 28. Vascular and Lymphatic Complications After Kidney Transplantation - p. 486 75. 29. Cardiovascular Disease in Renal Transplantation - p. 516 76. 30. Infection in Kidney Transplant Recipients - p. 540 77. CHAPTER OUTLINE - p. 540 78. Overview - p. 540 79. Risk of Infection - p. 540 80. Timeline of Infection - p. 544 81. Assessment of Infectious Diseases in Recipients and Potential Donors Before Transplantation - p. 548 82. Selected Infections of Importance - p. 551 83. Conclusions - p. 561 84. References - p. 561 85. 31. Transplantation in a Pandemic: Lessons Learned From COVID-19 - p. 568 86. 32. Liver Disease Among Renal Transplant Recipients - p. 578 87. CHAPTER OUTLINE - p. 578 88. Overview of Incidence and Clinicopathological Associations - p. 578 89. Combined Liver and Kidney Diseases - p. 579 90. Specific Immunosuppressive Agents in Renal Transplantation and Hepatotoxicity - p. 581 91. Hepatitis Viruses Associated With Renal Transplantation - p. 582 92. Nonalcoholic Fatty Liver Disease and Renal Transplant - p. 595 93. Hepatocellular Carcinoma After Renal Transplantation - p. 597 94. Systemic Infections Resulting in Hepatitis and Liver Disease - p. 598 95. References - p. 600 96. 33. Neurological Complications After Kidney Transplantation - p. 607 97. 34. Cutaneous Disease in Kidney Transplantation Patients - p. 621 98. 35. Cancer in Kidney Failure and Kidney Transplantation - p. 636 99. 36. Pancreas and Kidney Transplantation for Diabetic Nephropathy - p. 653 100. 37. Kidney Transplantation in Children - p. 679 101. CHAPTER OUTLINE - p. 679 102. Introduction - p. 679 103. Epidemiology of End-Stage Kidney Disease in Children - p. 680 104. Access to Transplantation - p. 681 105. Timing of Transplantation - p. 684 106. Patient and Graft Survival - p. 684 107. Contraindications to Transplantation - p. 688 108. Recurrence of Original Disease - p. 688 109. Pretransplant Evaluation - p. 695 110. Perioperative Management of Pediatric Renal Transplant Recipients - p. 699 111. Immunosuppressive Protocols and Drugs - p. 700 112. Acute Rejection in Pediatric Transplantation - p. 705 113. Long-Term Management Posttransplant - p. 707 114. References - p. 710 115. 38. Advancing Kidney Transplantation in Low- and Middle-Income Countries: Challenges and Strategies - p. 721 116. 39. Results of Kidney Transplantation - p. 733 117. 40. Psychosocial Aspects of Kidney Transplantation and Living Kidney Donation - p. 760 118. 41. Ethical and Legal Aspects of Kidney Donation - p. 775 119. 42. Xenotransplantation - p. 791 120. 43. Evidence in Transplantation - p. 803 121. Index - p. 813
