**Selected for 2026 Doody's Core Titles in Veterinary Medicine**
Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, health, and care for species involved in research. Edited by recognized veterinary, operational, and research experts and endorsed as the official material for veterinary specialty certification by ACLAM, this work defines the standard for all aspects of humane laboratory animal care and science with animal models.
This new edition contains significant changes in content and organization to reflect the evolution of the field. The animal welfare chapter has been moved to the beginning of the book to highlight this subject’s importance. Other chapters have either been consolidated to encourage the reader to recognize commonalities such as those between guinea pigs, gerbils and hamsters, or separated out in recognition of expansions in knowledge and cross-species complexity as illustrated by separate new and old world primate chapters. Advances in practice, technology, and knowledge are highlighted in the chapters on genetically modified organisms, with updates on new techniques in genetic engineering and consideration of non-rodent genetically modified models; microbiological monitoring, with an increased emphasis on environmental monitoring and sentinel free colony health monitoring methods; regulatory compliance, with a comprehensive chapter on birds; employee health and safety, with expanded consideration of compassion fatigue; and animal models in biomedical research, with increased emphasis on experimental design and rigor. New chapters on animal models for microbiome, infectious disease, and transplant research have been added to serve as a reference for the community.
This book is an excellent reference for veterinarians and research scientists, as well as program directors and facility managers employed in a variety of academic and corporate settings. This edition continues the tradition of this text in setting standards for the research animal science community as well as expanding and updating relevant and essential topics for this specialty field.
1. I Introduction - p. 107 2. II Biology - p. 117 3. III Diseases - p. 133 4. A Infectious Diseases - p. 133 5. 1 Microbiological Surveillance and Diagnostics - p. 133 6. 2 Viral Agents (DNA) - p. 134 7. 3 Viral Agents (RNA) - p. 142 8. 4 Bacterial Infections - p. 153 9. 5 Mycotic Infections - p. 173 10. 6 Parasitic Infections - p. 174 11. B Nonneoplastic Diseases and Conditions - p. 180 12. C Neoplastic Conditions - p. 192 13. Chapter 6. Biology and Diseases of Rats - p. 215 14. I Introduction - p. 215 15. II Biology - p. 218 16. III Diseases - p. 233 17. A Infectious Diseases - p. 233 18. 1 Bacterial, Mycoplasmal, and Rickettsial Infections - p. 233 19. 2 Viral Infections - p. 244 20. 3 Parasitic Infections - p. 250 21. 4 Fungal Infections - p. 257 22. B Noninfectious Diseases - p. 259 23. C Neoplastic Diseases - p. 262 24. D Miscellaneous Conditions - p. 264 25. Chapter 7. Biology and Diseases of Guinea Pigs, Gerbils, and Hamsters - p. 287 26. Guinea Pigs - p. 287 27. I Guinea Pigs - Introduction - p. 287 28. II Biology of Guinea Pigs - p. 290 29. III Diseases of Guinea Pigs - p. 296 30. A Infectious Diseases - p. 296 31. B Metabolic and Nutritional Disorders - p. 308 32. C Traumatic Disorders - p. 313 33. D Iatrogenic and Management-Related Disorders - p. 314 34. E Neoplastic Diseases - p. 315 35. F Congenital, Age-Related, and Miscellaneous Conditions - p. 315 36. Gerbils - p. 326 37. I Gerbils - Introduction - p. 326 38. II Biology of Gerbils - p. 330 39. III Diseases of Gerbils - p. 331 40. Syrian Hamster - p. 341 41. I Introduction - p. 341 42. II Biology of Syrian Hamsters - p. 345 43. III Diseases of Syrian Hamsters - p. 351 44. Chinese Hamster - p. 364 45. I Introduction - p. 364 46. II Biology of the Chinese Hamster - p. 364 47. III Diseases of the Chinese Hamster - p. 365 48. Armenian Hamster - p. 368 49. I Introduction - p. 368 50. II Biology of the Armenian Hamster - p. 368 51. III Diseases of the Armenian Hamster - p. 368 52. European Hamster - p. 369 53. I Introduction - p. 369 54. II Biology of the European Hamster - p. 369 55. III Diseases of the European Hamster - p. 370 56. Djungarian Hamster - p. 371 57. I Introduction - p. 371 58. II Biology of the Djungarian Hamster - p. 371 59. III Diseases of the Djungarian Hamster - p. 372 60. Chapter 8. Biology and Diseases of Other Rodents - p. 385 61. I Introduction - p. 385 62. II Hystricomorph Rodents - p. 388 63. III Degus: (Octodon degus) - p. 391 64. IV Sciuromorph Rodents - p. 394 65. V Prairie Dogs: Cynomys - p. 397 66. VI Eastern Woodchuck (Marmota monax) - p. 401 67. VII Myomorphic Rodents - p. 405 68. VIII Deer Mice: Peromyscus - p. 408 69. IX Multimammate Rats/Mice: Mastomys - p. 411 70. X Naked Mole-Rats: Heterocephalus glaber - p. 413 71. XI Nile Grass Rat (Arvicanthis niloticus) - p. 417 72. XII Voles: Microtus - p. 418 73. XIII Conclusion - p. 422 74. Chapter 9. Biology and Diseases of Rabbits - p. 433 75. I Introduction - p. 433 76. II Biology - p. 434 77. III Diseases - p. 442 78. A Bacterial Diseases - p. 442 79. B Viral Diseases - p. 457 80. C Protozoal Diseases - p. 461 81. D Arthropod and Helminth Diseases - p. 464 82. E Mycotic Diseases - p. 465 83. F Management-Related Diseases - p. 468 84. G Heritable Diseases - p. 469 85. H Neoplasia - p. 475 86. I Miscellaneous Diseases - p. 476 87. Chapter 10. Microbiological Quality Control for Laboratory Rodents - p. 497 88. I Introduction - p. 497 89. II Specific Pathogen Free Specifications - p. 498 90. III Diagnostic Methodologies for Health Monitoring - p. 499 91. IV Microbiologic Quality Control Program Management - p. 520 92. Chapter 11. Biology and Diseases of Dogs - p. 553 93. I Introduction - p. 553 94. II Biology - p. 556 95. III Diseases - p. 563 96. A Infectious Diseases - p. 564 97. 1 Bacterial and Mycoplasmal Diseases - p. 564 98. 2 Viral and Chlamydial Diseases - p. 569 99. 3 Parasitic Diseases - p. 570 100. 4 Fungal Diseases - p. 573 101. B Metabolic and Nutritional Diseases - p. 573 102. C Environmental, Behavioral, and Traumatic Disorders - p. 578 103. D Congenital, Aging-Related, and Miscellaneous Disorders - p. 582 104. E Neoplastic Diseases - p. 593 105. Chapter 12. Biology and Diseases of Cats - p. 609 106. Chapter 13. Biology and Diseases of Ferrets - p. 639 107. I Introduction - p. 639 108. II Biology - p. 642 109. III Diseases - p. 651 110. Chapter 14. Biology and Diseases of Ruminants (Sheep, Goats, and Cattle) - p. 695 111. I Introduction - p. 695 112. II Biology - p. 699 113. III Diseases - p. 717 114. A Infectious Diseases - p. 717 115. 1 Bacterial/Mycoplasmal/Rickettsial - p. 717 116. 2 Viral Diseases - p. 738 117. 3 Prion Diseases - p. 751 118. 4 Parasitic Diseases - p. 752 119. 5 Fungal - p. 762 120. B Genetic/Congenital Diseases - p. 762 121. C Metabolic Diseases - p. 764 122. D Neoplastic Diseases - p. 775 123. E Miscellaneous - p. 776 124. Major References Addressing Husbandry, Management, and Clinical Medicine - p. 776 125. Sources of Information - p. 776 126. Chapter 15. Biology and Diseases of Swine - p. 787 127. I Introduction - p. 787 128. II Biology - p. 792 129. III Diseases - p. 800 130. A Infectious Diseases - p. 800 131. 1 Polysystemic Diseases - p. 800 132. 2 Respiratory Diseases - p. 813 133. 3 Gastrointestinal Diseases - p. 823 134. 4 Circulatory Disease - p. 837 135. 5 Skin Diseases - p. 838 136. 6 Reproductive Diseases - p. 842 137. 7 Vesicular Diseases - p. 846 138. 8 Newly Reported or Emerging Infectious Diseases/Agents - p. 849 139. B Metabolic/Nutritional Diseases - p. 852 140. C Iatrogenic Diseases - p. 855 141. D Neoplastic Diseases - p. 855 142. E Miscellaneous - p. 856 143. Acronyms Used in Chapter - p. 856 144. Chapter 16. New World Nonhuman Primates - p. 883 145. I Introduction - p. 883 146. II Taxonomy - p. 884 147. III Biology - p. 886 148. IV Principles of Colony Management - p. 909 149. V Medical Management - p. 914 150. VI Diseases - p. 923 151. A Bacterial Diseases - p. 923 152. B Mycotic Diseases - p. 933 153. C Viral Diseases - p. 935 154. 1 Enveloped DNA Viruses - p. 935 155. 2 Nonenveloped DNA Viruses - p. 942 156. 3 Enveloped RNA Viruses - p. 945 157. 4 Nonenveloped RNA Viruses - p. 952 158. D Microsporidial Diseases - p. 953 159. E Parasitic Diseases - p. 955 160. 1 Giardia intestinalis - p. 955 161. 2 Trichomonads - p. 959 162. 3 Entamoeba histolytica - p. 965 163. 4 Toxoplasma gondii - p. 967 164. 5 Trypanosoma cruzi - p. 968 165. 6 Plasmodium spp. – P. simium and P. brasilianum - p. 969 166. 7 Prosthenorchis elegans and P. spirula - p. 970 167. 8 Trichospirura Leptostoma - p. 970 168. F Nutritional Diseases - p. 971 169. G Noninfectious Diseases and Other Conditions - p. 979 170. Chapter 17. Old World Nonhuman Primates - p. 1031 171. I Introduction - p. 1031 172. II Taxonomy - p. 1032 173. III Biology - p. 1033 174. A Macaca spp.: Macaque Monkeys - p. 1033 175. B Papio spp.: Baboons - p. 1045 176. C Chlorocebus spp.: African Green Monkeys - p. 1050 177. D Pan spp.: Chimpanzees - p. 1055 178. IV Principles of Colony Management - p. 1055 179. IV Medical Management - p. 1061 180. VI Diseases - p. 1078 181. A Bacterial Diseases - p. 1078 182. B Mycotic Diseases - p. 1091 183. C Viral Diseases - p. 1094 184. 1 DNA Viruses - p. 1094 185. 2 RNA Viruses - p. 1103 186. D Parasitic Diseases - p. 1109 187. E Nutritional Diseases - p. 1115 188. F Noninfectious Diseases and Other Conditions - p. 1116 189. Chapter 18. Biology, Management, and Diseases of the Zebrafish - p. 1157 190. I Zebrafish as a Model Organism - p. 1157 191. II Commonly Used Experimental Methods - p. 1165 192. III Biology - p. 1173 193. IV Environmental Factors Important to Zebrafish Health - p. 1185 194. V General Features of Laboratory Zebrafish Facilities - p. 1189 195. VI Nutrition and Feeding of Zebrafish - p. 1195 196. VII Techniques, Pain, Analgesia, Anesthesia, and Euthanasia - p. 1196 197. VIII Health, Welfare, and Colony Management in the Zebrafish Facility - p. 1201 198. IX Significant Diseases of Laboratory Zebrafish - p. 1215 199. A Bacterial Infections - p. 1215 200. 1 Mycobacteriosis - p. 1215 201. 2 Edwardsiellosis - p. 1220 202. 3 Motile Aeromonas Septicemia (Ulcer Disease, Aeromoniasis, Red Sore) - p. 1222 203. 4 Flavobacteriosis (Columnaris, Fin Rot, Cotton Wool Disease) - p. 1223 204. B Fungus-like Infections - p. 1224 205. C Viral Infections - p. 1230 206. D Protozoal - p. 1234 207. E Metazoan Infections - p. 1238 208. F Water Quality Diseases - p. 1242 209. G Neoplasia - p. 1245 210. H Other Diseases - p. 1248 211. Chapter 19. Biology and Diseases of Amphibians - p. 1283 212. I Introduction - p. 1283 213. II Biology - p. 1291 214. III Diseases - p. 1302 215. Chapter 20. Biology and Diseases of Reptiles - p. 1325 216. I Introduction - p. 1325 217. II Biology - p. 1333 218. III Diseases - p. 1344 219. Chapter 21. Birds in Biomedical Research - p. 1379 220. I Introduction - p. 1379 221. II Biology - p. 1386 222. B Anatomical Differences Between Bird Species - p. 1387 223. III Use of Birds in Research - p. 1391 224. I Antibody Production - p. 1394 225. IV Laboratory Management and Husbandry - p. 1395 226. V Food and Water - p. 1405 227. VI Breeding and Rearing - p. 1407 228. VII Veterinary Care and Procedures - p. 1411 229. VIII Diseases/Welfare Concerns - p. 1415 230. Chapter 22. Animal Models in Biomedical Research - p. 1457 231. Chapter 23. Techniques of Experimentation - p. 1477 232. I Introduction - p. 1477 233. II Identification Methods - p. 1478 234. III Blood Collection and Intravenous Injection - p. 1480 235. IV Vascular Cannulation - p. 1489 236. V Intraperitoneal Injection - p. 1494 237. VI Subcutaneous, Intramuscular, and Intraosseous Injection - p. 1495 238. VII Digestive System - p. 1495 239. VIII Urinary System Techniques - p. 1502 240. IX Respiratory System Techniques - p. 1504 241. X Reproductive System - p. 1508 242. XI Cardiovascular Techniques - p. 1513 243. XII Endocrine System Techniques - p. 1515 244. XIII Orthopedic Procedures for Laboratory Animals - p. 1517 245. XIV Neurosurgical Techniques - p. 1518 246. XV Tumor Transplantation - p. 1524 247. XVI Imaging Techniques - p. 1525 248. XVII Radiotelemetry and Digital Telemetrics - p. 1526 249. XVIII Thymectomy - p. 1527 250. Chapter 24. Anesthesia, Analgesia, and Euthanasia - p. 1555 251. I Introduction - p. 1555 252. II Rodent Anesthesia, Analgesia, and Euthanasia - p. 1559 253. III Rabbit Anesthesia, Analgesia, and Euthanasia - p. 1574 254. IV Ferret Anesthesia, Analgesia and Euthanasia - p. 1587 255. V Swine Anesthesia, Analgesia and Euthanasia - p. 1595 256. VI Small Ruminant Anesthesia, Analgesia and Euthansia - p. 1603 257. VII Nonhuman Primates Anesthesia, Analgesia and Euthanasia - p. 1611 258. Chapter 25. Factors that May Influence Animal Research - p. 1639 259. I Introduction - p. 1639 260. II Intrinsic Considerations - p. 1639 261. III Extrinsic Considerations - p. 1642 262. A Physical Factors - p. 1643 263. B Chemical Factors - p. 1657 264. 1 Xenobiotics (Other than Pharmaceuticals) - p. 1657 265. 2 Pharmaceuticals - p. 1660 266. 3 Pheromones - p. 1664 267. C Microbial Agents - p. 1664 268. D Stressors - p. 1667 269. E Personnel Influences - p. 1669 270. Chapter 26. Design and Management of Animal Research Facilities - p. 1701 271. I Introduction - p. 1701 272. II Facility Planning and Design - p. 1702 273. III Environmental Control and Monitoring - p. 1728 274. IV Housing and Equipment - p. 1735 275. V Materials - p. 1744 276. VI Operational Issues - p. 1752 277. VII Conclusions - p. 1757 278. Chapter 27. Comprehensive Occupational Health and Safety: Promoting Physical and Mental Well Being for Workers, Visitors, and Others Exposed to Research Animals and Their Tissues - p. 1769 279. Chapter 28. Selected Zoonoses - p. 1795 280. I Introduction - p. 1795 281. II Viral Diseases - p. 1795 282. III Rickettsial Diseases - p. 1818 283. IV Chlamydial Infections - p. 1821 284. V Bacterial Diseases - p. 1822 285. VI Fungal Diseases - p. 1836 286. VII Protozoal Diseases - p. 1837 287. VIII Helminth Infections - p. 1842 288. IX Arthropod Infestations - p. 1842 289. Chapter 29. Gnotobiotics - p. 1863 290. Chapter 30. The Microbiome of Laboratory Animals - p. 1901 291. I Introduction - p. 1901 292. II Terminology - p. 1901 293. III General Characteristics of Gut Microbiomes - p. 1902 294. IV Characterization and Analysis of the Gut Microbiome - p. 1904 295. V Composition of Host-Associated Microbiomes - p. 1906 296. VI Extrinsic Factors Affecting the Microbiome of Laboratory Animals - p. 1915 297. VII Experimental Manipulation of the Microbiome - p. 1918 298. Chapter 31. Infectious Disease Research and Biocontainment - p. 1939 299. Chapter 32. Transplant Medicine (Including Allogeneic and Xenogeneic) - p. 1965 300. Chapter 33. Program Management - p. 1989 301. Chapter 34. Research Animal Behavior - p. 2017 302. I Introduction - p. 2017 303. II Rodents - p. 2019 304. III Rabbits - p. 2027 305. IV Dogs and Cats - p. 2029 306. V Nonhuman Primates - p. 2038 307. VI Farm Animals - p. 2044 308. Index - p. 2073
**Selected for 2026 Doody's Core Titles in Veterinary Medicine**
Laboratory Animal Medicine, Fourth Edition—a volume in the American College of Laboratory Animal Medicine (ACLAM) blue book series—is the authoritative reference on the biology, health, and care for species involved in research. Edited by recognized veterinary, operational, and research experts and endorsed as the official material for veterinary specialty certification by ACLAM, this work defines the standard for all aspects of humane laboratory animal care and science with animal models.
This new edition contains significant changes in content and organization to reflect the evolution of the field. The animal welfare chapter has been moved to the beginning of the book to highlight this subject’s importance. Other chapters have either been consolidated to encourage the reader to recognize commonalities such as those between guinea pigs, gerbils and hamsters, or separated out in recognition of expansions in knowledge and cross-species complexity as illustrated by separate new and old world primate chapters. Advances in practice, technology, and knowledge are highlighted in the chapters on genetically modified organisms, with updates on new techniques in genetic engineering and consideration of non-rodent genetically modified models; microbiological monitoring, with an increased emphasis on environmental monitoring and sentinel free colony health monitoring methods; regulatory compliance, with a comprehensive chapter on birds; employee health and safety, with expanded consideration of compassion fatigue; and animal models in biomedical research, with increased emphasis on experimental design and rigor. New chapters on animal models for microbiome, infectious disease, and transplant research have been added to serve as a reference for the community.
This book is an excellent reference for veterinarians and research scientists, as well as program directors and facility managers employed in a variety of academic and corporate settings. This edition continues the tradition of this text in setting standards for the research animal science community as well as expanding and updating relevant and essential topics for this specialty field.
1. I Introduction - p. 107 2. II Biology - p. 117 3. III Diseases - p. 133 4. A Infectious Diseases - p. 133 5. 1 Microbiological Surveillance and Diagnostics - p. 133 6. 2 Viral Agents (DNA) - p. 134 7. 3 Viral Agents (RNA) - p. 142 8. 4 Bacterial Infections - p. 153 9. 5 Mycotic Infections - p. 173 10. 6 Parasitic Infections - p. 174 11. B Nonneoplastic Diseases and Conditions - p. 180 12. C Neoplastic Conditions - p. 192 13. Chapter 6. Biology and Diseases of Rats - p. 215 14. I Introduction - p. 215 15. II Biology - p. 218 16. III Diseases - p. 233 17. A Infectious Diseases - p. 233 18. 1 Bacterial, Mycoplasmal, and Rickettsial Infections - p. 233 19. 2 Viral Infections - p. 244 20. 3 Parasitic Infections - p. 250 21. 4 Fungal Infections - p. 257 22. B Noninfectious Diseases - p. 259 23. C Neoplastic Diseases - p. 262 24. D Miscellaneous Conditions - p. 264 25. Chapter 7. Biology and Diseases of Guinea Pigs, Gerbils, and Hamsters - p. 287 26. Guinea Pigs - p. 287 27. I Guinea Pigs - Introduction - p. 287 28. II Biology of Guinea Pigs - p. 290 29. III Diseases of Guinea Pigs - p. 296 30. A Infectious Diseases - p. 296 31. B Metabolic and Nutritional Disorders - p. 308 32. C Traumatic Disorders - p. 313 33. D Iatrogenic and Management-Related Disorders - p. 314 34. E Neoplastic Diseases - p. 315 35. F Congenital, Age-Related, and Miscellaneous Conditions - p. 315 36. Gerbils - p. 326 37. I Gerbils - Introduction - p. 326 38. II Biology of Gerbils - p. 330 39. III Diseases of Gerbils - p. 331 40. Syrian Hamster - p. 341 41. I Introduction - p. 341 42. II Biology of Syrian Hamsters - p. 345 43. III Diseases of Syrian Hamsters - p. 351 44. Chinese Hamster - p. 364 45. I Introduction - p. 364 46. II Biology of the Chinese Hamster - p. 364 47. III Diseases of the Chinese Hamster - p. 365 48. Armenian Hamster - p. 368 49. I Introduction - p. 368 50. II Biology of the Armenian Hamster - p. 368 51. III Diseases of the Armenian Hamster - p. 368 52. European Hamster - p. 369 53. I Introduction - p. 369 54. II Biology of the European Hamster - p. 369 55. III Diseases of the European Hamster - p. 370 56. Djungarian Hamster - p. 371 57. I Introduction - p. 371 58. II Biology of the Djungarian Hamster - p. 371 59. III Diseases of the Djungarian Hamster - p. 372 60. Chapter 8. Biology and Diseases of Other Rodents - p. 385 61. I Introduction - p. 385 62. II Hystricomorph Rodents - p. 388 63. III Degus: (Octodon degus) - p. 391 64. IV Sciuromorph Rodents - p. 394 65. V Prairie Dogs: Cynomys - p. 397 66. VI Eastern Woodchuck (Marmota monax) - p. 401 67. VII Myomorphic Rodents - p. 405 68. VIII Deer Mice: Peromyscus - p. 408 69. IX Multimammate Rats/Mice: Mastomys - p. 411 70. X Naked Mole-Rats: Heterocephalus glaber - p. 413 71. XI Nile Grass Rat (Arvicanthis niloticus) - p. 417 72. XII Voles: Microtus - p. 418 73. XIII Conclusion - p. 422 74. Chapter 9. Biology and Diseases of Rabbits - p. 433 75. I Introduction - p. 433 76. II Biology - p. 434 77. III Diseases - p. 442 78. A Bacterial Diseases - p. 442 79. B Viral Diseases - p. 457 80. C Protozoal Diseases - p. 461 81. D Arthropod and Helminth Diseases - p. 464 82. E Mycotic Diseases - p. 465 83. F Management-Related Diseases - p. 468 84. G Heritable Diseases - p. 469 85. H Neoplasia - p. 475 86. I Miscellaneous Diseases - p. 476 87. Chapter 10. Microbiological Quality Control for Laboratory Rodents - p. 497 88. I Introduction - p. 497 89. II Specific Pathogen Free Specifications - p. 498 90. III Diagnostic Methodologies for Health Monitoring - p. 499 91. IV Microbiologic Quality Control Program Management - p. 520 92. Chapter 11. Biology and Diseases of Dogs - p. 553 93. I Introduction - p. 553 94. II Biology - p. 556 95. III Diseases - p. 563 96. A Infectious Diseases - p. 564 97. 1 Bacterial and Mycoplasmal Diseases - p. 564 98. 2 Viral and Chlamydial Diseases - p. 569 99. 3 Parasitic Diseases - p. 570 100. 4 Fungal Diseases - p. 573 101. B Metabolic and Nutritional Diseases - p. 573 102. C Environmental, Behavioral, and Traumatic Disorders - p. 578 103. D Congenital, Aging-Related, and Miscellaneous Disorders - p. 582 104. E Neoplastic Diseases - p. 593 105. Chapter 12. Biology and Diseases of Cats - p. 609 106. Chapter 13. Biology and Diseases of Ferrets - p. 639 107. I Introduction - p. 639 108. II Biology - p. 642 109. III Diseases - p. 651 110. Chapter 14. Biology and Diseases of Ruminants (Sheep, Goats, and Cattle) - p. 695 111. I Introduction - p. 695 112. II Biology - p. 699 113. III Diseases - p. 717 114. A Infectious Diseases - p. 717 115. 1 Bacterial/Mycoplasmal/Rickettsial - p. 717 116. 2 Viral Diseases - p. 738 117. 3 Prion Diseases - p. 751 118. 4 Parasitic Diseases - p. 752 119. 5 Fungal - p. 762 120. B Genetic/Congenital Diseases - p. 762 121. C Metabolic Diseases - p. 764 122. D Neoplastic Diseases - p. 775 123. E Miscellaneous - p. 776 124. Major References Addressing Husbandry, Management, and Clinical Medicine - p. 776 125. Sources of Information - p. 776 126. Chapter 15. Biology and Diseases of Swine - p. 787 127. I Introduction - p. 787 128. II Biology - p. 792 129. III Diseases - p. 800 130. A Infectious Diseases - p. 800 131. 1 Polysystemic Diseases - p. 800 132. 2 Respiratory Diseases - p. 813 133. 3 Gastrointestinal Diseases - p. 823 134. 4 Circulatory Disease - p. 837 135. 5 Skin Diseases - p. 838 136. 6 Reproductive Diseases - p. 842 137. 7 Vesicular Diseases - p. 846 138. 8 Newly Reported or Emerging Infectious Diseases/Agents - p. 849 139. B Metabolic/Nutritional Diseases - p. 852 140. C Iatrogenic Diseases - p. 855 141. D Neoplastic Diseases - p. 855 142. E Miscellaneous - p. 856 143. Acronyms Used in Chapter - p. 856 144. Chapter 16. New World Nonhuman Primates - p. 883 145. I Introduction - p. 883 146. II Taxonomy - p. 884 147. III Biology - p. 886 148. IV Principles of Colony Management - p. 909 149. V Medical Management - p. 914 150. VI Diseases - p. 923 151. A Bacterial Diseases - p. 923 152. B Mycotic Diseases - p. 933 153. C Viral Diseases - p. 935 154. 1 Enveloped DNA Viruses - p. 935 155. 2 Nonenveloped DNA Viruses - p. 942 156. 3 Enveloped RNA Viruses - p. 945 157. 4 Nonenveloped RNA Viruses - p. 952 158. D Microsporidial Diseases - p. 953 159. E Parasitic Diseases - p. 955 160. 1 Giardia intestinalis - p. 955 161. 2 Trichomonads - p. 959 162. 3 Entamoeba histolytica - p. 965 163. 4 Toxoplasma gondii - p. 967 164. 5 Trypanosoma cruzi - p. 968 165. 6 Plasmodium spp. – P. simium and P. brasilianum - p. 969 166. 7 Prosthenorchis elegans and P. spirula - p. 970 167. 8 Trichospirura Leptostoma - p. 970 168. F Nutritional Diseases - p. 971 169. G Noninfectious Diseases and Other Conditions - p. 979 170. Chapter 17. Old World Nonhuman Primates - p. 1031 171. I Introduction - p. 1031 172. II Taxonomy - p. 1032 173. III Biology - p. 1033 174. A Macaca spp.: Macaque Monkeys - p. 1033 175. B Papio spp.: Baboons - p. 1045 176. C Chlorocebus spp.: African Green Monkeys - p. 1050 177. D Pan spp.: Chimpanzees - p. 1055 178. IV Principles of Colony Management - p. 1055 179. IV Medical Management - p. 1061 180. VI Diseases - p. 1078 181. A Bacterial Diseases - p. 1078 182. B Mycotic Diseases - p. 1091 183. C Viral Diseases - p. 1094 184. 1 DNA Viruses - p. 1094 185. 2 RNA Viruses - p. 1103 186. D Parasitic Diseases - p. 1109 187. E Nutritional Diseases - p. 1115 188. F Noninfectious Diseases and Other Conditions - p. 1116 189. Chapter 18. Biology, Management, and Diseases of the Zebrafish - p. 1157 190. I Zebrafish as a Model Organism - p. 1157 191. II Commonly Used Experimental Methods - p. 1165 192. III Biology - p. 1173 193. IV Environmental Factors Important to Zebrafish Health - p. 1185 194. V General Features of Laboratory Zebrafish Facilities - p. 1189 195. VI Nutrition and Feeding of Zebrafish - p. 1195 196. VII Techniques, Pain, Analgesia, Anesthesia, and Euthanasia - p. 1196 197. VIII Health, Welfare, and Colony Management in the Zebrafish Facility - p. 1201 198. IX Significant Diseases of Laboratory Zebrafish - p. 1215 199. A Bacterial Infections - p. 1215 200. 1 Mycobacteriosis - p. 1215 201. 2 Edwardsiellosis - p. 1220 202. 3 Motile Aeromonas Septicemia (Ulcer Disease, Aeromoniasis, Red Sore) - p. 1222 203. 4 Flavobacteriosis (Columnaris, Fin Rot, Cotton Wool Disease) - p. 1223 204. B Fungus-like Infections - p. 1224 205. C Viral Infections - p. 1230 206. D Protozoal - p. 1234 207. E Metazoan Infections - p. 1238 208. F Water Quality Diseases - p. 1242 209. G Neoplasia - p. 1245 210. H Other Diseases - p. 1248 211. Chapter 19. Biology and Diseases of Amphibians - p. 1283 212. I Introduction - p. 1283 213. II Biology - p. 1291 214. III Diseases - p. 1302 215. Chapter 20. Biology and Diseases of Reptiles - p. 1325 216. I Introduction - p. 1325 217. II Biology - p. 1333 218. III Diseases - p. 1344 219. Chapter 21. Birds in Biomedical Research - p. 1379 220. I Introduction - p. 1379 221. II Biology - p. 1386 222. B Anatomical Differences Between Bird Species - p. 1387 223. III Use of Birds in Research - p. 1391 224. I Antibody Production - p. 1394 225. IV Laboratory Management and Husbandry - p. 1395 226. V Food and Water - p. 1405 227. VI Breeding and Rearing - p. 1407 228. VII Veterinary Care and Procedures - p. 1411 229. VIII Diseases/Welfare Concerns - p. 1415 230. Chapter 22. Animal Models in Biomedical Research - p. 1457 231. Chapter 23. Techniques of Experimentation - p. 1477 232. I Introduction - p. 1477 233. II Identification Methods - p. 1478 234. III Blood Collection and Intravenous Injection - p. 1480 235. IV Vascular Cannulation - p. 1489 236. V Intraperitoneal Injection - p. 1494 237. VI Subcutaneous, Intramuscular, and Intraosseous Injection - p. 1495 238. VII Digestive System - p. 1495 239. VIII Urinary System Techniques - p. 1502 240. IX Respiratory System Techniques - p. 1504 241. X Reproductive System - p. 1508 242. XI Cardiovascular Techniques - p. 1513 243. XII Endocrine System Techniques - p. 1515 244. XIII Orthopedic Procedures for Laboratory Animals - p. 1517 245. XIV Neurosurgical Techniques - p. 1518 246. XV Tumor Transplantation - p. 1524 247. XVI Imaging Techniques - p. 1525 248. XVII Radiotelemetry and Digital Telemetrics - p. 1526 249. XVIII Thymectomy - p. 1527 250. Chapter 24. Anesthesia, Analgesia, and Euthanasia - p. 1555 251. I Introduction - p. 1555 252. II Rodent Anesthesia, Analgesia, and Euthanasia - p. 1559 253. III Rabbit Anesthesia, Analgesia, and Euthanasia - p. 1574 254. IV Ferret Anesthesia, Analgesia and Euthanasia - p. 1587 255. V Swine Anesthesia, Analgesia and Euthanasia - p. 1595 256. VI Small Ruminant Anesthesia, Analgesia and Euthansia - p. 1603 257. VII Nonhuman Primates Anesthesia, Analgesia and Euthanasia - p. 1611 258. Chapter 25. Factors that May Influence Animal Research - p. 1639 259. I Introduction - p. 1639 260. II Intrinsic Considerations - p. 1639 261. III Extrinsic Considerations - p. 1642 262. A Physical Factors - p. 1643 263. B Chemical Factors - p. 1657 264. 1 Xenobiotics (Other than Pharmaceuticals) - p. 1657 265. 2 Pharmaceuticals - p. 1660 266. 3 Pheromones - p. 1664 267. C Microbial Agents - p. 1664 268. D Stressors - p. 1667 269. E Personnel Influences - p. 1669 270. Chapter 26. Design and Management of Animal Research Facilities - p. 1701 271. I Introduction - p. 1701 272. II Facility Planning and Design - p. 1702 273. III Environmental Control and Monitoring - p. 1728 274. IV Housing and Equipment - p. 1735 275. V Materials - p. 1744 276. VI Operational Issues - p. 1752 277. VII Conclusions - p. 1757 278. Chapter 27. Comprehensive Occupational Health and Safety: Promoting Physical and Mental Well Being for Workers, Visitors, and Others Exposed to Research Animals and Their Tissues - p. 1769 279. Chapter 28. Selected Zoonoses - p. 1795 280. I Introduction - p. 1795 281. II Viral Diseases - p. 1795 282. III Rickettsial Diseases - p. 1818 283. IV Chlamydial Infections - p. 1821 284. V Bacterial Diseases - p. 1822 285. VI Fungal Diseases - p. 1836 286. VII Protozoal Diseases - p. 1837 287. VIII Helminth Infections - p. 1842 288. IX Arthropod Infestations - p. 1842 289. Chapter 29. Gnotobiotics - p. 1863 290. Chapter 30. The Microbiome of Laboratory Animals - p. 1901 291. I Introduction - p. 1901 292. II Terminology - p. 1901 293. III General Characteristics of Gut Microbiomes - p. 1902 294. IV Characterization and Analysis of the Gut Microbiome - p. 1904 295. V Composition of Host-Associated Microbiomes - p. 1906 296. VI Extrinsic Factors Affecting the Microbiome of Laboratory Animals - p. 1915 297. VII Experimental Manipulation of the Microbiome - p. 1918 298. Chapter 31. Infectious Disease Research and Biocontainment - p. 1939 299. Chapter 32. Transplant Medicine (Including Allogeneic and Xenogeneic) - p. 1965 300. Chapter 33. Program Management - p. 1989 301. Chapter 34. Research Animal Behavior - p. 2017 302. I Introduction - p. 2017 303. II Rodents - p. 2019 304. III Rabbits - p. 2027 305. IV Dogs and Cats - p. 2029 306. V Nonhuman Primates - p. 2038 307. VI Farm Animals - p. 2044 308. Index - p. 2073
