Lanthanides in Enzymology and Microbiology, a new volume in the Foundations and Frontiers in Enzymology Series, offers a detailed discussion of lanthanides and lanthanide-dependent enzyme biology. In this book, more than a dozen global experts consider lanthanide enzymology fundamentals, organismal utilization of lanthanides, distribution and diversity of lanthanide-dependent enzymes, regulation of intracellular levels of lanthanides, gene expression regulation via lanthanides, as well as likely applications of lanthanide binding proteins. Lanthanide-dependent methanol and alcohol dehydrogenase metabolism are considered in both methylotrophs and non-methylotrophs, alongside various application areas, from recovery of rare earth elements to developing lanthanide ion binding peptides and biosynthesis of terpolymers through reverse-oxidation pathways. In providing this deep context and pathways for future research, this book acts as an invaluable resource in this emerging field for researchers and students of biochemistry, biotechnology, and environmental microbiology alike.
1. Part I: Introduction - p. xiv 2. 1. Lanthanide utilization by organisms: An overview - p. 3 3. 2. Distribution and diversity of lanthanide-dependent methanol dehydrogenase, XoxF, in natural environments - p. 29 4. Part II: Lanthanide-dependent methanol dehydrogenases in methylotrophs - p. 35 5. Discovery of the Xox system in Methylobacteriumextorquens AM1: A historical perspective - p. 43 6. XoxF5-type methanol dehydrogenase and lanthanide-dependent methylotrophy in Methylorubrum extorquens AM1 - p. 53 7. Lanthanide uptake and gene regulation of the xox1 operon in Methylobacterium extorquens AM1 - p. 73 8. Lanthanide utilization in Methylobacterium aquaticum strain 22A - p. 91 9. Part III: Lanthanide-dependent methanol dehydrogenases and methanol metabolisms in methanotrophs - p. 102 10. Genetic regulation by lanthanides in the Type I methanotroph Methylotuvimicrobium buryatense 5GB1C - p. 107 11. XoxF4, represented by two enzymes from Methylotenera mobilis JLW8 - p. 121 12. Part IV: Lanthanide-dependent methanol/alcohol dehydrogenases in nonmethylotrophs and newly found methylotrophs - p. 129 13. Lanthanide-dependent methanol dehydrogenases, XoxFs, in Rhizobia of α-Proteobacteria - p. 133 14. 10. Lanthanide utilization in the family Beijerinckiaceae - p. 147 15. 11. Lanthanide utilization in newly found methylotrophs - p. 175 16. Part V: Application of lanthanide-dependent biological processes - p. 204 17. 12. Recovery of rare earth elements using lanmodulin - p. 211 18. 13. Development of lanthanide ion binding peptide - p. 241 19. Switching between methanol accumulation and cell growth by expression control of methanol dehydrogenase in Methylosinus trichosporium OB3b - p. 267 20. Index - p. 285
Lanthanides in Enzymology and Microbiology, a new volume in the Foundations and Frontiers in Enzymology Series, offers a detailed discussion of lanthanides and lanthanide-dependent enzyme biology. In this book, more than a dozen global experts consider lanthanide enzymology fundamentals, organismal utilization of lanthanides, distribution and diversity of lanthanide-dependent enzymes, regulation of intracellular levels of lanthanides, gene expression regulation via lanthanides, as well as likely applications of lanthanide binding proteins. Lanthanide-dependent methanol and alcohol dehydrogenase metabolism are considered in both methylotrophs and non-methylotrophs, alongside various application areas, from recovery of rare earth elements to developing lanthanide ion binding peptides and biosynthesis of terpolymers through reverse-oxidation pathways. In providing this deep context and pathways for future research, this book acts as an invaluable resource in this emerging field for researchers and students of biochemistry, biotechnology, and environmental microbiology alike.
1. Part I: Introduction - p. xiv 2. 1. Lanthanide utilization by organisms: An overview - p. 3 3. 2. Distribution and diversity of lanthanide-dependent methanol dehydrogenase, XoxF, in natural environments - p. 29 4. Part II: Lanthanide-dependent methanol dehydrogenases in methylotrophs - p. 35 5. Discovery of the Xox system in Methylobacteriumextorquens AM1: A historical perspective - p. 43 6. XoxF5-type methanol dehydrogenase and lanthanide-dependent methylotrophy in Methylorubrum extorquens AM1 - p. 53 7. Lanthanide uptake and gene regulation of the xox1 operon in Methylobacterium extorquens AM1 - p. 73 8. Lanthanide utilization in Methylobacterium aquaticum strain 22A - p. 91 9. Part III: Lanthanide-dependent methanol dehydrogenases and methanol metabolisms in methanotrophs - p. 102 10. Genetic regulation by lanthanides in the Type I methanotroph Methylotuvimicrobium buryatense 5GB1C - p. 107 11. XoxF4, represented by two enzymes from Methylotenera mobilis JLW8 - p. 121 12. Part IV: Lanthanide-dependent methanol/alcohol dehydrogenases in nonmethylotrophs and newly found methylotrophs - p. 129 13. Lanthanide-dependent methanol dehydrogenases, XoxFs, in Rhizobia of α-Proteobacteria - p. 133 14. 10. Lanthanide utilization in the family Beijerinckiaceae - p. 147 15. 11. Lanthanide utilization in newly found methylotrophs - p. 175 16. Part V: Application of lanthanide-dependent biological processes - p. 204 17. 12. Recovery of rare earth elements using lanmodulin - p. 211 18. 13. Development of lanthanide ion binding peptide - p. 241 19. Switching between methanol accumulation and cell growth by expression control of methanol dehydrogenase in Methylosinus trichosporium OB3b - p. 267 20. Index - p. 285
